{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T15:34:49Z","timestamp":1765294489300},"reference-count":34,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2012,1]]},"abstract":"\nObject<\/jats:title>\nThe objective of this study was to evaluate the efficacy of chronic subthalamic nucleus (STN) stimulation for alleviating pain related to Parkinson disease (PD).<\/jats:p><\/jats:sec>\n\nMethods<\/jats:title>\nAmong 163 consecutive patients undergoing STN stimulation, 69 were identified as experiencing pain preoperatively that was related to their PD. All 69 patients suffering from pain were followed up prospectively for 12 months after surgery. All patients described the severity of their pain according to a visual analog scale (VAS) preoperatively and at 2 weeks, 6 months, and 12 months postoperatively. Pain unrelated to PD was not studied.<\/jats:p><\/jats:sec>\n\nResults<\/jats:title>\nSeveral types of pain related to PD, the categories of which were based on a modification of 2 previous classifications (Ford and Honey), can occur in such patients: 1) musculoskeletal pain, 2) dystonic pain, 3) somatic pain exacerbated by PD, 4) radicular\/peripheral neuropathic pain, and 5) central pain. The overall mean VAS score was significantly decreased postoperatively by 75% and 69% at 2 weeks and 6 months, respectively (p < 0.001). The mean VAS score at 12 months was also decreased by 80%, but 6 instances of pain (3 reports of somatic back pain and 3 reports of radicular\/peripheral neuropathic pain) required additional spinal surgery to alleviate the pain severity. The results were analyzed using the Wilcoxon signed-rank test and demonstrated a significant reduction in VAS scores at all follow-up assessments (p < 0.001). Musculoskeletal pain and dystonic pain were well alleviated by STN stimulation. In contrast, somatic pain exacerbated by PD and peripheral neuropathic pain originating from lumbar spinal diseases, such as spondylosis deformans and\/or canal stenosis, often deteriorated postoperatively despite attenuation of the patients' motor disability. Patients with central pain were poor responders.<\/jats:p><\/jats:sec>\n\nConclusions<\/jats:title>\nThis study found that STN stimulation produced significant improvement of overall pain related to PD in patients with advanced PD, and the efficacy continued for at least 1 year. The present results indicate that musculoskeletal pain and dystonic pain responded well to STN stimulation, but patients with back pain (somatic pain) and radicular\/peripheral neuropathic pain originating from spinal disease have a potential risk for postoperative deterioration of their pain.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2011.7.jns11158","type":"journal-article","created":{"date-parts":[[2011,9,9]],"date-time":"2011-09-09T21:23:12Z","timestamp":1315603392000},"page":"99-106","source":"Crossref","is-referenced-by-count":45,"title":["Subthalamic nucleus stimulation for attenuation of pain related to Parkinson disease"],"prefix":"10.3171","volume":"116","author":[{"given":"Hideki","family":"Oshima","sequence":"first","affiliation":[{"name":"Departments of Neurological Surgery,"},{"name":"Functional Morphology, and"},{"name":"Division of Applied System Neuroscience, Department of Advanced Medical Science, Nihon University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi","family":"Katayama","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery,"},{"name":"Division of Applied System Neuroscience, Department of Advanced Medical Science, Nihon University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Morishita","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichiro","family":"Sumi","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiharu","family":"Otaka","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazutaka","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Neurology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chikashi","family":"Fukaya","sequence":"additional","affiliation":[{"name":"Division of Applied System Neuroscience, Department of Advanced Medical Science, Nihon University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takamitsu","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Division of Applied System Neuroscience, Department of Advanced Medical Science, Nihon University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-jns11158","series-title":"Ann Neurol","first-page":"355","article-title":"Treatment of advanced Parkinson's disease by posterior GPi pallidotomy: 1-year results of a pilot study","volume":"40","author":"Baron","year":"1996"},{"key":"b2-jns11158","series-title":"Mov Disord","first-page":"1641","article-title":"The PRIAMO study: a multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease","volume":"24","author":"Barone","year":"2009"},{"key":"b3-jns11158","series-title":"Pain","first-page":"173","article-title":"Pain in Parkinson's disease: prevalence and characteristics","volume":"141","author":"Beiske","year":"2009"},{"key":"b4-jns11158","series-title":"Mov Disord","first-page":"1557","article-title":"Effect of levodopa on pain threshold in Parkinson's disease: a clinical and positron emission tomography 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Descriptions of Chronic Pain Syndromes and Definitions of Pain Terms","first-page":"43","article-title":"Relatively generalized syndromes: central pain","author":"Task Force on Taxonomy of the International Association for the Study of Pain","year":"1994"},{"key":"b32-jns11158","series-title":"Pain","first-page":"117","article-title":"Abnormal processing of the nociceptive input in Parkinson's disease: a study with CO2 laser evoked potentials","volume":"136","author":"Tinazzi","year":"2008"},{"key":"b33-jns11158","series-title":"J Neurol Neurosurg Psychiatry","first-page":"822","article-title":"Pain and motor complication in Parkinson's disease","volume":"77","author":"Tinazzi","year":"2009"},{"key":"b34-jns11158","series-title":"Mov Disord","first-page":"1729","article-title":"Effects of chronic subthalamic stimulation on nonmotor fluctuations in Parkinson's disease","volume":"22","author":"Witjas","year":"2007"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/116\/1\/article-p99.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/116\/1\/article-p99.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/116\/1\/article-p99.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T01:33:31Z","timestamp":1679880811000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/116\/1\/article-p99.xml"}},"subtitle":["Clinical article"],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":34,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3171\/2011.7.jns11158","relation":{},"ISSN":["0022-3085","1933-0693"],"issn-type":[{"value":"0022-3085","type":"print"},{"value":"1933-0693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1]]}}}