{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T08:55:46Z","timestamp":1771577746341,"version":"3.50.1"},"reference-count":19,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PED"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:p>The authors describe the case of a late preterm infant girl who presented prenatally with a low lumbar neural tube defect and features of Chiari malformation type II (CM-II). At birth, she exhibited stridor and underwent surgical repair of a lumbosacral myelomeningocele on Day 2 of life. The prognosis was deemed to be poor, and hence a \u201cChiari decompression\u201d procedure was not undertaken. The patient was subsequently extubated and died on Day 10. Postmortem findings included a rarely described but characteristic granulomatous meningitic reaction to vernix caseosa, which presumably entered the subarachnoid space and spinal cord syrinx antenatally via the open neural tube defect. The significance of congenital stridor in the context of CM-II and in particular the role of vernix caseosa granulomatous meningitis are examined. The antenatal repair of myelomeningoceles, as championed by some, may prevent this ominous meningitic complication.<\/jats:p>","DOI":"10.3171\/2011.7.peds11208","type":"journal-article","created":{"date-parts":[[2011,9,30]],"date-time":"2011-09-30T17:12:05Z","timestamp":1317402725000},"page":"372-376","source":"Crossref","is-referenced-by-count":8,"title":["Congenital stridor in the context of Chiari malformation Type II: the etiological role of vernix caseosa granulomatous meningitis"],"prefix":"10.3171","volume":"8","author":[{"given":"Amelie I.","family":"Stritzke","sequence":"first","affiliation":[{"name":"Division of Neonatology;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher P.","family":"Dunham","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Division of Anatomic Pathology; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Smyth","sequence":"additional","affiliation":[{"name":"Division of Neonatology;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Steinbok","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Neurosurgery, Children's and Women's Health Center of British Columbia; and"},{"name":"University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-0080372","series-title":"N Engl J Med","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1056\/NEJMoa1014379","article-title":"A randomized trial of prenatal versus postnatal repair of myelomeningocele","volume":"364","author":"Adzick","year":"2011"},{"key":"b2-0080372","series-title":"Semin Pediatr Surg","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/S1055-8586(03)00029-5","article-title":"Myelomeningocele: prenatal diagnosis, pathophysiology and management","volume":"12","author":"Adzick","year":"2003"},{"key":"b3-0080372","series-title":"Surg Neurol","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/0090-3019(86)90236-3","article-title":"Arnold-Chiari malformation. Report of four cases with contamination of the central nervous system by amniotic contents","volume":"25","author":"Agamanolis","year":"1986"},{"key":"b4-0080372","series-title":"J Pediatr","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/S0022-3476(68)80047-2","article-title":"Aseptic meningitic syndrome with cauda equina epidermoid tumor","volume":"73","author":"Cantu","year":"1968"},{"key":"b5-0080372","series-title":"Pediatr Neurosurg","first-page":"232","article-title":"Apnea in patients with myelomeningocele","volume":"16","author":"Cochrane","year":"1991"},{"key":"b6-0080372","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"718","DOI":"10.3171\/jns.1975.42.6.0718","article-title":"Vernix caseosa meningitis and laryngeal stridor in an infant with myelomeningocele. Case report","volume":"42","author":"Correa-Restrepo","year":"1975"},{"key":"b7-0080372","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"60","DOI":"10.3171\/jns.1967.27.1.0060","article-title":"Intraspinal dermoid tumor presenting as chemical meningitis. Report of a case without dermal sinus","volume":"27","author":"Decker","year":"1967"},{"key":"b8-0080372","series-title":"Arch Dis Child","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1136\/adc.40.214.687","article-title":"Laryngeal stridor and respiratory obstruction associated with meningomyelocele","volume":"40","author":"Fitzsimmons","year":"1965"},{"key":"b9-0080372","series-title":"Developmental Neuropathology","author":"Golden","year":"2004"},{"key":"b10-0080372","series-title":"Am J Pathol","first-page":"345","article-title":"Vernicomyelia. Its bearing on theories of genesis of the Arnold-Chiari complex","volume":"39","author":"Jacobs","year":"1961"},{"key":"b11-0080372","series-title":"Can J Neurol Sci","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1017\/S0317167100031309","article-title":"Vernix caseo granulomatous meningitis (vernicomyelia)","volume":"18","author":"Midha","year":"1991"},{"key":"b12-0080372","series-title":"Pediatr Emerg Care","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1097\/01.pec.0000280523.61064.15","article-title":"Stridor in an infant with myelomeningocele","volume":"23","author":"Nagler","year":"2007"},{"key":"b13-0080372","series-title":"Indian J Pediatr","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1007\/BF02753300","article-title":"Vocal cord paralysis in neuraxial malformation","volume":"50","author":"Ravilochan","year":"1983"},{"key":"b14-0080372","series-title":"Neurology","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1212\/WNL.28.2.124","article-title":"Recurrent meningitis due to an intracranial epidermoid","volume":"28","author":"Schwartz","year":"1978"},{"key":"b15-0080372","series-title":"Surg Neurol","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/0090-3019(84)90206-4","article-title":"Rathke cleft cysts","volume":"21","author":"Shimoji","year":"1984"},{"key":"b16-0080372","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"541","DOI":"10.3171\/jns.1992.77.4.0541","article-title":"Surgical decompression for symptomatic Chiari II malformation in neonates with myelomeningocele","volume":"77","author":"Vandertop","year":"1992"},{"key":"b17-0080372","series-title":"J Perinatol","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1038\/sj.jp.7211305","article-title":"Vernix caseosa in neonatal adaptation","volume":"25","author":"Visscher","year":"2005"},{"key":"b18-0080372","series-title":"Fetal Diagn Ther","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1159\/000053934","article-title":"The Rationale for in utero repair of myelomeningocele","volume":"16","author":"Walsh","year":"2001"},{"key":"b19-0080372","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1007\/BF00270814","article-title":"Laryngeal stridor associated with the Chiari II malformation","volume":"1","author":"Yamada","year":"1985"}],"container-title":["Journal of Neurosurgery: Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/8\/4\/article-p372.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/8\/4\/article-p372.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/8\/4\/article-p372.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T15:48:51Z","timestamp":1681573731000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/8\/4\/article-p372.xml"}},"subtitle":["Case report"],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":19,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.3171\/2011.7.peds11208","relation":{},"ISSN":["1933-0707","1933-0715"],"issn-type":[{"value":"1933-0707","type":"print"},{"value":"1933-0715","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10]]}}}