{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:08:20Z","timestamp":1761844100426},"reference-count":87,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:sec>\n<jats:title>Object<\/jats:title>\n<jats:p>Adipose lesions of nerve are rare and poorly understood. Their current classification, although not universally accepted, generally includes lipomatosis of nerve with or without localized macrodactyly, and intra- as well as extraneural lipoma. The authors believe that the spectrum of these lesions and their interrelationships are not currently appreciated. They propose an adaptation to the existing framework to illustrate the expanding spectrum of adipose lesions of nerve by considering lipomatosis and lipoma singly or in combination.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Fourteen representative cases are presented to demonstrate not only the intraneural and extraneural examples of lipomatosis and lipoma, but also their anatomical combinations.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Based on the cases presented and a careful literature review, a conceptual approach to the classification of adipose lesions of nerve is generated. This approach incorporates the 2 essential lesions, lipomatosis of nerve and lipoma, in both their intra- and extraneural forms. This permits expansion to encompass combinations.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>To press the concept that adipose tumors of nerve are a broad but interrelated spectrum of lesions, the authors propose modification of the present classification system. This approach provides an orderly platform for progress, reflects understanding of these interrelated lesions, and facilitates optimal treatment by distinguishing resectable from nonresectable components.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2011.8.jns101292","type":"journal-article","created":{"date-parts":[[2011,10,7]],"date-time":"2011-10-07T19:48:10Z","timestamp":1318016890000},"page":"418-431","source":"Crossref","is-referenced-by-count":53,"title":["Adipose lesions of nerve: the need for a modified classification"],"prefix":"10.3171","volume":"116","author":[{"given":"Robert J.","family":"Spinner","sequence":"first","affiliation":[{"name":"Departments of Neurologic Surgery,"},{"name":"Orthopedics, Mayo Clinic, Rochester, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd W.","family":"Scheithauer","sequence":"additional","affiliation":[{"name":"Laboratory Medicine and Pathology,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly K.","family":"Amrami","sequence":"additional","affiliation":[{"name":"Departments of Neurologic Surgery,"},{"name":"Radiology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doris E.","family":"Wenger","sequence":"additional","affiliation":[{"name":"Radiology, and"},{"name":"Orthopedics, Mayo Clinic, Rochester, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-No\u00eblle","family":"H\u00e9bert-Blouin","sequence":"additional","affiliation":[{"name":"Departments of Neurologic Surgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-jns101292","series-title":"J Hand Surg Am","first-page":"160","article-title":"Lipofibroma of the median nerve","volume":"4","author":"Abu Jamra","year":"1979"},{"key":"b2-jns101292","series-title":"J Clin Neurosci","first-page":"1323","article-title":"Spinal epidural lipomatosis\u2014a brief review","volume":"15","author":"Al-Khawaja","year":"2008"},{"key":"b3-jns101292","series-title":"J Hand Surg Br","first-page":"368","article-title":"Lipofibromatous hamartoma of the median nerve and its associated conditions","volume":"26","author":"Al-Qattan","year":"2001"},{"key":"b4-jns101292","series-title":"Hand Surg","first-page":"43","article-title":"Classification of benign fatty tumours of the upper limb","volume":"10","author":"Al-Qattan","year":"2005"},{"key":"b5-jns101292","series-title":"J Hand Surg Am","first-page":"67","article-title":"Lipofibromatous hamartoma of nerve","volume":"13","author":"Amadio","year":"1988"},{"key":"b6-jns101292","series-title":"AFIP Atlas of Tumor Pathology: Tumors of the Peripheral Nervous System","author":"Antonescu","year":"2012"},{"key":"b7-jns101292","series-title":"Am J Med Genet A","first-page":"63","article-title":"Macrodystrophia lipomatosa of the feet and subcutaneous lipomas","volume":"119A","author":"Aydos","year":"2003"},{"key":"b8-jns101292","series-title":"Can J Plast Surg","first-page":"49","article-title":"Intraneural lipoma of the ulnar nerve: a case report and review of literature","volume":"14","author":"Balakrishnan","year":"2006"},{"key":"b9-jns101292","series-title":"Int Orthop","first-page":"77","article-title":"Monomelic macrodystrophia lipomatosa. 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