{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T22:54:38Z","timestamp":1775343278223,"version":"3.50.1"},"reference-count":13,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2011,12]]},"abstract":"\nObject<\/jats:title>\nCommunicating hydrocephalus is an uncommon complication in patients treated for glioblastoma multiforme (GBM). Its pathogenesis remains unclear. The authors evaluated the clinical and radiological factors associated with the onset of communicating hydrocephalus and the impact of ventriculoperitoneal (VP) shunt surgery on the outcome of these patients.<\/jats:p><\/jats:sec>\n\nMethods<\/jats:title>\nOne hundred twenty-four patients harboring GBM, who had undergone craniotomy for tumor resection and adjuvant radiochemotherapy, were retrospectively assessed. Seven of them developed communicating hydrocephalus and were treated with VP shunt surgery. Clinical and radiological estimates included Karnofsky Performance Scale (KPS) score, previous surgery, overall survival (OS), CSF pressure and components, tumor location, and leptomeningeal dissemination.<\/jats:p><\/jats:sec>\n\nResults<\/jats:title>\nAll 7 patients who developed communicating hydrocephalus had undergone at least 2 craniotomies for tumor resection before the onset of hydrocephalus (p = 0.0006; Fisher exact test). Six cases showed high levels of CSF proteins. There was a highly significant relationship between ventricular opening at surgery for tumor recurrence and onset of hydrocephalus (p = 0.0002; Fisher exact test). In these patients, VP shunt surgery was followed by a significant improvement of KPS score (p = 0.0180; Wilcoxon signed-rank test). The median OS after VP shunt insertion was 5 \u00b1 2.9 months.<\/jats:p><\/jats:sec>\n\nConclusions<\/jats:title>\nVentricular opening after radiochemotherapy and high CSF protein levels are significant predictors of communicating hydrocephalus in patients with GBM. The VP shunt surgery improves quality of life in these patients.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2011.8.jns11738","type":"journal-article","created":{"date-parts":[[2011,9,9]],"date-time":"2011-09-09T21:23:12Z","timestamp":1315603392000},"page":"1126-1130","source":"Crossref","is-referenced-by-count":53,"title":["Communicating hydrocephalus following surgery and adjuvant radiochemotherapy for glioblastoma"],"prefix":"10.3171","volume":"115","author":[{"given":"Nicola","family":"Montano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quintino Giorgio","family":"D'Alessandris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Bianchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liverana","family":"Lauretti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Doglietto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Fernandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulio","family":"Maira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Pallini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-jns11738","series-title":"Nihon Geka Hokan","first-page":"508","article-title":"Communicating hydrocephalus occurring in the postoperative course of glioblastoma multiforme","volume":"58","author":"Ando","year":"1989"},{"key":"b2-jns11738","series-title":"J Neurosurg","first-page":"604","article-title":"Factors involved in maintaining prolonged functional independence following supratentorial glioblastoma resection. Clinical article","volume":"114","author":"Chaichana","year":"2011"},{"key":"b3-jns11738","series-title":"Clin Neurol Neurosurg","first-page":"9","article-title":"Postoperative communicating hydrocephalus in patients with supratentorial malignant glioma","volume":"106","author":"Inamasu","year":"2003"},{"key":"b4-jns11738","series-title":"J Neurosurg","first-page":"190","article-title":"A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival","volume":"95","author":"Lacroix","year":"2001"},{"key":"b5-jns11738","series-title":"WHO Classification of Tumours of the Central Nervous System","first-page":"33","year":"2007"},{"key":"b6-jns11738","series-title":"Acta Neurochir (Wien)","first-page":"227","article-title":"Delayed hydrocephalus after resection of supratentorial malignant gliomas","volume":"144","author":"Marquardt","year":"2002"},{"key":"b7-jns11738","series-title":"Neuroradiology","first-page":"146","article-title":"Symptomatic cerebrospinal fluid dissemination of cerebral glioblastoma. Computed tomographic findings in 11 cases","volume":"32","author":"Onda","year":"1990"},{"key":"b8-jns11738","series-title":"Clin Cancer Res","first-page":"8205","article-title":"Cancer stem cell analysis and clinical outcome in patients with glioblastoma multiforme","volume":"14","author":"Pallini","year":"2008"},{"key":"b9-jns11738","series-title":"Neurol Sci","first-page":"237","article-title":"Radiation leukoencephalopathy associated with moderate hydrocephalus: intracranial pressure monitoring and results of ventriculoperitoneal shunting","volume":"23","author":"Perrini","year":"2002"},{"key":"b10-jns11738","series-title":"Acta Neurochir (Wien)","first-page":"41","article-title":"The value of ventriculoperitoneal shunting in patients with glioblastoma multiforme and ventriculomegaly","volume":"150","author":"Roth","year":"2008"},{"issue":"Suppl","key":"b11-jns11738","series-title":"J Neurosurg","first-page":"106","article-title":"Prospective trial of gross-total resection with Gliadel wafers followed by early postoperative Gamma Knife radiosurgery and conformal fractionated radiotherapy as the initial treatment for patients with radiographically suspected, newly diagnosed glioblastoma multiforme","volume":"109","author":"Smith","year":"2008"},{"key":"b12-jns11738","series-title":"N Engl J Med","first-page":"987","article-title":"Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma","volume":"352","author":"Stupp","year":"2005"},{"key":"b13-jns11738","series-title":"Arch Neurol","first-page":"705","article-title":"Hydrocephalus in radiation leukoencephalopathy: results of ventriculoperitoneal shunting","volume":"55","author":"Thiessen","year":"1998"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/115\/6\/article-p1126.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/115\/6\/article-p1126.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/115\/6\/article-p1126.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T02:30:58Z","timestamp":1679884258000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/115\/6\/article-p1126.xml"}},"subtitle":["Clinical article"],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":13,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.3171\/2011.8.jns11738","relation":{},"ISSN":["0022-3085","1933-0693"],"issn-type":[{"value":"0022-3085","type":"print"},{"value":"1933-0693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12]]}}}