{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T22:48:40Z","timestamp":1776725320444,"version":"3.51.2"},"reference-count":33,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2012,5]]},"abstract":"\nObject<\/jats:title>\nThe treatment of acute intracranial vertebrobasilar artery occlusion (VBO) has been described but often with poor results. The authors of this study set out to evaluate their institution's outcomes following multimodal treatment of VBO.<\/jats:p><\/jats:sec>\n\nMethods<\/jats:title>\nThey retrospectively reviewed their endovascular database for all patients treated for acute intracranial VBO between December 2004 and June 2010. Twenty-four patients were identified. Two patients were excluded from evaluation\u2014one because of incomplete medical records and one because the etiology was basilar stenosis and not stroke. Occlusion location, hypercoagulable causes, time to endovascular treatment, time to revascularization, comorbidities, devices used, procedural anticoagulation, and outcomes were analyzed.<\/jats:p><\/jats:sec>\n\nResults<\/jats:title>\nAmong the 22 eligible study patients, the mean National Institutes of Health Stroke Scale (NIHSS) score at presentation was 15.3. The mean time from presentation to initiation of the endovascular procedure was 4.77 hours. The mean time for recanalization from the start of angiography was 1.63 hours. In 16 patients (73%), revascularization was successful (Thrombolysis in Myocardial Infarction [TIMI] score of 2 or 3). Thirteen (59%) of the 22 patients were discharged to home or a rehabilitation facility. One patient was transferred to a chronic care facility. The overall survival rate was 64%. The average NIHSS score for the 14 surviving patients at discharge was 3.9. At the follow-up (average 14.5 months, range 1\u201358 months), 10 patients (71%) had achieved good outcomes (modified Rankin Scale [mRS] score \u2264 2) and 4 (29%) had poor outcomes (mRS Score 3\u20136).<\/jats:italic><\/jats:p><\/jats:sec>\n\nConclusions<\/jats:title>\nPublished case series have historically shown poor outcomes and high mortality rates in association with the treatment of acute VBO, prompting surgeons to be less aggressive in the treatment of this disease than they might be otherwise. Data in this series show that the revascularization of posterior circulation occlusions is feasible and that good outcomes and lower mortality rates with newer endovascular technologies are possible, and thus more prompt and aggressive treatment of this disease may be warranted.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2012.1.jns11997","type":"journal-article","created":{"date-parts":[[2012,2,3]],"date-time":"2012-02-03T15:04:50Z","timestamp":1328281490000},"page":"952-960","source":"Crossref","is-referenced-by-count":3,"title":["Treatment and outcomes of acute intracranial vertebrobasilar artery occlusion: one institution's experience"],"prefix":"10.3171","volume":"116","author":[{"given":"Sharon","family":"Webb","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery and"},{"name":"Department of Neurosurgery, Millard Fillmore Gates Circle Hospital\u2013Kaleida Health, Buffalo, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parham","family":"Yashar","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"},{"name":"Department of Neurosurgery, Millard Fillmore Gates Circle Hospital\u2013Kaleida Health, Buffalo, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Kan","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"},{"name":"Department of Neurosurgery, Millard Fillmore Gates Circle Hospital\u2013Kaleida Health, Buffalo, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adnan H.","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"},{"name":"Radiology, School of Medicine and Biomedical Sciences;"},{"name":"Toshiba Stroke Research Center, University at Buffalo, State University of New York; and"},{"name":"Department of Neurosurgery, Millard Fillmore Gates Circle Hospital\u2013Kaleida Health, Buffalo, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. Nelson","family":"Hopkins","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"},{"name":"Radiology, School of Medicine and Biomedical Sciences;"},{"name":"Toshiba Stroke Research Center, University at Buffalo, State University of New York; and"},{"name":"Department of Neurosurgery, Millard Fillmore Gates Circle Hospital\u2013Kaleida Health, Buffalo, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elad I.","family":"Levy","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"},{"name":"Radiology, School of Medicine and Biomedical Sciences;"},{"name":"Toshiba Stroke Research Center, University at Buffalo, State University of New York; and"},{"name":"Department of Neurosurgery, Millard Fillmore Gates Circle Hospital\u2013Kaleida Health, Buffalo, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-jns11997","series-title":"Stroke","first-page":"383","article-title":"Basilar artery occlusion: clinical and radiological correlation","volume":"8","author":"Archer","year":"1977"},{"key":"b2-jns11997","series-title":"J Neurol Neurosurg Psychiatry","first-page":"857","article-title":"Clinical and radiological predictors of recanalisation and outcome of 40 patients with acute basilar artery occlusion treated with intra-arterial thrombolysis","volume":"75","author":"Arnold","year":"2004"},{"key":"b3-jns11997","series-title":"AJNR Am J Neuroradiol","first-page":"255","article-title":"Intraarterial thrombolysis in vertebrobasilar occlusion","volume":"17","author":"Becker","year":"1996"},{"key":"b4-jns11997","series-title":"Cerebrovasc Dis","first-page":"183","article-title":"Long-term outcome after local intra-arterial fibrinolysis of basilar artery thrombosis","volume":"10","author":"Berg-Dammer","year":"2000"},{"key":"b5-jns11997","series-title":"Stroke","first-page":"875","article-title":"Thrombolytic therapy of acute basilar artery occlusion. 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