{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T18:54:08Z","timestamp":1767034448209},"reference-count":32,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PED"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p>Atypical teratoid\/rhabdoid tumor (AT\/RT) is an aggressive embryonic brain tumor predominantly seen in young children. The authors report an unusual case of a fourth ventricle AT\/RT in an infant who survived for 26 years. The tumor was resected when the patient was 6 months of age, and radiation therapy (40-Gy total dose) was performed thereafter. The patient was free from the disease for 26 years until a recurrent tumor was found in the spinal cord. The spinal cord neoplasm was a \u201ccollision tumor\u201d with 2 components: benign schwannoma and recurrent AT\/RT. The patient died of dissemination of the recurrent tumor 5 months after it was excised. This is the longest survival of a patient with AT\/RT ever reported and indicates that long-term survival, more than 20 years, can be achieved in infantile-onset AT\/RT. Despite intensive treatment, the prognosis for AT\/RT is very poor, especially in children younger than 3 years of age. The benefits of upfront radiation therapy for AT\/RT should be carefully assessed with respect to its inevitable toxicity in very young children. However, early upfront radiation therapy may be of therapeutic interest to prevent aggressive progression of the disease.<\/jats:p>","DOI":"10.3171\/2012.1.peds11350","type":"journal-article","created":{"date-parts":[[2012,3,30]],"date-time":"2012-03-30T15:02:16Z","timestamp":1333119736000},"page":"400-405","source":"Crossref","is-referenced-by-count":16,"title":["Atypical teratoid\/rhabdoid tumor with 26-year overall survival"],"prefix":"10.3171","volume":"9","author":[{"given":"Junko","family":"Takahashi-Fujigasaki","sequence":"first","affiliation":[{"name":"Division of Neuropathology, The Jikei University School of Medicine;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayoshi","family":"Matumoto","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Omori Red Cross Hospital, Tokyo; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Issei","family":"Kan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Omori Red Cross Hospital, Tokyo; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidehiro","family":"Oka","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kitasato University School of Medicine, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaharu","family":"Yasue","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Omori Red Cross Hospital, Tokyo; and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-0090400","series-title":"Neuroradiology","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1007\/s002340050900","article-title":"Primary malignant rhabdoid tumour of the brain in an adult","volume":"42","author":"Arrazola","year":"2000"},{"key":"b2-0090400","series-title":"Ultrastruct Pathol","doi-asserted-by":"publisher","first-page":"369","DOI":"10.3109\/01913129709021935","article-title":"Central nervous system atypical teratoid\/rhabdoid tumors of infancy and childhood","volume":"21","author":"Bhattacharjee","year":"1997"},{"key":"b3-0090400","series-title":"Cancer Res","first-page":"74","article-title":"Germ-line and acquired mutations of INI1 in atypical teratoid and rhabdoid tumors","volume":"59","author":"Biegel","year":"1999"},{"key":"b4-0090400","series-title":"Hum Pathol","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/S0046-8177(87)80161-2","article-title":"Malignant rhabdoid tumor of the central nervous system","volume":"18","author":"Biggs","year":"1987"},{"key":"b5-0090400","series-title":"J Pathol","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1002\/path.2103","article-title":"hSNF5\/INI1-deficient tumours and rhabdoid tumours are convergent but not fully overlapping entities","volume":"211","author":"Bourdeaut","year":"2007"},{"key":"b6-0090400","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/s00381-007-0438-y","article-title":"Atypical teratoid\/rhabdoid tumour: 7-year event-free survival with gross total resection and radiotherapy in a 7-year-old boy","volume":"24","author":"Bouvier","year":"2008"},{"key":"b7-0090400","series-title":"Am J Surg Pathol","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1097\/00000478-199809000-00007","article-title":"Atypical teratoid\/rhabdoid tumor of the central nervous system: a highly malignant tumor of infancy and childhood frequently mistaken for medulloblastoma: a Pediatric Oncology Group study","volume":"22","author":"Burger","year":"1998"},{"key":"b8-0090400","series-title":"Int J Radiat Oncol Biol Phys","first-page":"247","article-title":"Regarding Weiss et al., IJROBP 41: 103\u2013109; 1998","volume":"45","author":"Byram","year":"1999"},{"key":"b9-0090400","series-title":"Arch Pathol Lab Med","first-page":"350","article-title":"Metastases to primary intracranial meningiomas and neurilemomas","volume":"104","author":"Chambers","year":"1980"},{"key":"b10-0090400","series-title":"J Clin Oncol","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1200\/JCO.2008.18.7724","article-title":"Intensive multimodality treatment for children with newly diagnosed CNS atypical teratoid rhabdoid tumor","volume":"27","author":"Chi","year":"2009"},{"key":"b11-0090400","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1007\/s00381-003-0731-3","article-title":"Atypical teratoid\/rhabdoid tumors","volume":"19","author":"Dang","year":"2003"},{"key":"b12-0090400","series-title":"Pediatr Neurosurg","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1159\/000091866","article-title":"Atypical teratoid\/rhabdoid tumor of the velum interpositum presenting as a spontaneous intraventricular hemorrhage in an infant: case report with long-term survival","volume":"42","author":"Donovan","year":"2006"},{"key":"b13-0090400","series-title":"Am J Surg Pathol","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1097\/01.pas.0000213329.71745.ef","article-title":"Immunohistochemical analysis of INI1 protein in malignant pediatric CNS tumors: lack of INI1 in atypical teratoid\/rhabdoid tumors and in a fraction of primitive neuroectodermal tumors without rhabdoid phenotype","volume":"30","author":"Haberler","year":"2006"},{"key":"b14-0090400","series-title":"J Clin Oncol","doi-asserted-by":"publisher","first-page":"2877","DOI":"10.1200\/JCO.2004.07.073","article-title":"Central nervous system atypical teratoid\/rhabdoid tumor: results of therapy in children enrolled in a registry","volume":"22","author":"Hilden","year":"2004"},{"key":"b15-0090400","series-title":"Pediatr Hematol Oncol","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1080\/08880010390203116","article-title":"Cerebral atypical teratoid\/rhabdoid tumor of infancy: long-term survival after multimodal treatment, also including triple intrathecal chemotherapy and gamma knife radiosurgery\u2014case report","volume":"20","author":"Hirth","year":"2003"},{"key":"b16-0090400","series-title":"Acta Neuropathol","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1007\/BF00713540","article-title":"Malignant rhabdoid tumor: primary intracranial manifestation in an adult","volume":"83","author":"Horn","year":"1992"},{"key":"b17-0090400","series-title":"Am J Surg Pathol","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1097\/00000478-200405000-00013","article-title":"Immunohistochemical analysis of hSNF5\/INI1 in pediatric CNS neoplasms","volume":"28","author":"Judkins","year":"2004"},{"key":"b18-0090400","series-title":"Acta Neuropathol","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s00401-007-0243-4","article-title":"The 2007 WHO classification of tumours of the central nervous system","volume":"114","author":"Louis","year":"2007"},{"key":"b19-0090400","series-title":"J Neurooncol","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/s11060-008-9571-z","article-title":"Atypical teratoid rhabdoid tumor (AT\/RT) in adults: review of four cases","volume":"88","author":"Makuria","year":"2008"},{"key":"b20-0090400","series-title":"Neurol Med Chir (Tokyo)","doi-asserted-by":"publisher","first-page":"510","DOI":"10.2176\/nmc.39.510","article-title":"Clinicopathological characteristics of atypical teratoid\/rhabdoid tumor","volume":"39","author":"Oka","year":"1999"},{"key":"b21-0090400","series-title":"J Pediatr Hematol Oncol","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1097\/00043426-200206000-00004","article-title":"Atypical teratoid\/rhabdoid tumor of the central nervous system: report on workshop","volume":"24","author":"Packer","year":"2002"},{"key":"b22-0090400","series-title":"Pediatr Blood Cancer","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1002\/pbc.10419","article-title":"Treatment of CNS malignant rhabdoid tumors","volume":"42","author":"Ronghe","year":"2004"},{"key":"b23-0090400","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"56","DOI":"10.3171\/jns.1996.85.1.0056","article-title":"Central nervous system atypical teratoid\/rhabdoid tumors of infancy and childhood: definition of an entity","volume":"85","author":"Rorke","year":"1996"},{"key":"b24-0090400","series-title":"Cancer Res","first-page":"3152","article-title":"hSNF5\/INI1 inactivation is mainly associated with homozygous deletions and mitotic recombinations in rhabdoid tumors","volume":"59","author":"Rousseau-Merck","year":"1999"},{"key":"b25-0090400","series-title":"Pediatr Neurosurg","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1159\/000098392","article-title":"Giant supratentorial atypical teratoid\/rhabdoid tumor presentation: a case of a five-year-old child with favorable outcome and review of the literature","volume":"43","author":"Sasani","year":"2007"},{"key":"b26-0090400","series-title":"Neuropathology","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1111\/j.1440-1789.2010.01189.x","article-title":"Atypical teratoid\/rhabdoid tumors may show morphological and immunohistochemical features seen in choroid plexus tumors","volume":"31","author":"Schittenhelm","year":"2011"},{"key":"b27-0090400","series-title":"J Neurooncol","first-page":"97","article-title":"Atypical teratoid\/rhabdoid tumor: the controversy behind radiation therapy","volume":"81","author":"Squire","year":"2007"},{"key":"b28-0090400","series-title":"Brain Tumor Pathol","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s10014-010-0008-y","article-title":"Case of atypical teratoid\/rhabdoid tumor in an adult, with long survival","volume":"28","author":"Takahashi","year":"2011"},{"key":"b29-0090400","series-title":"Acta Neurochir (Wien)","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s00701-006-1049-1","article-title":"Lung adenocarcinoma metastasizing to cerebellopontine angle schwannoma (collision tumor)","volume":"149","author":"Tang","year":"2007"},{"key":"b30-0090400","series-title":"J Clin Oncol","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1200\/JCO.2005.05.187","article-title":"Atypical teratoid\/rhabdoid tumors (ATRT): improved survival in children 3 years of age and older with radiation therapy and high-dose alkylator-based chemotherapy","volume":"23","author":"Tekautz","year":"2005"},{"key":"b31-0090400","series-title":"Nature","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/28212","article-title":"Truncating mutations of hSNF5\/INI1 in aggressive paediatric cancer","volume":"394","author":"Versteege","year":"1998"},{"key":"b32-0090400","series-title":"Pathology","first-page":"664","article-title":"Rhabdoid tumour: a malignancy of early childhood with variable primary site, histology and clinical behaviour","volume":"40","author":"Wu","year":"2008"}],"container-title":["Journal of Neurosurgery: Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/9\/4\/article-p400.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/9\/4\/article-p400.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/9\/4\/article-p400.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T15:42:02Z","timestamp":1681573322000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/9\/4\/article-p400.xml"}},"subtitle":["Case report"],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":32,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.3171\/2012.1.peds11350","relation":{},"ISSN":["1933-0707","1933-0715"],"issn-type":[{"value":"1933-0707","type":"print"},{"value":"1933-0715","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4]]}}}