{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:34:36Z","timestamp":1767706476818},"reference-count":22,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PED"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:sec>\n<jats:title>Object<\/jats:title>\n<jats:p>Intracranial neoplasms are the second most common childhood cancer, and lead to significant morbidity and mortality. Hyponatremia is a complication associated with neurosurgical procedures, but children undergoing intracranial tumor resection have not been selectively studied. In this study, the authors aimed to determine the incidence and risk factors associated with hyponatremia among children undergoing intracranial neoplasm resection.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>A retrospective cohort was compiled using the 2006 Kids' Inpatient Database to identify children younger than 21 years of age who underwent intracranial neoplasm resection. Hyponatremia was ascertained by diagnosis codes. Bivariate analyses were conducted using chi-square and Mann-Whitney U-tests. Logistic regression models were developed to evaluate factors associated with hyponatremia in bivariate analyses.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Hyponatremia occurred in 205 (8.7%) of 2343 annual weighted cases, and was independently associated with tumor location in the deep brain structures and ventricles compared with the cortical area (adjusted odds ratio [aOR] 2.4; 95% CI 1.1\u20135.3). Hyponatremia was also associated with obstructive hydrocephalus (aOR 2.7; 95% CI 1.7\u20134.3) and emergency department admission (aOR 1.7; 95% CI 1.1\u20132.4). Hyponatremia was significantly associated with mechanical ventilation, ventriculostomy placement, ventriculoperitoneal shunt placement, and sepsis. Hyponatremia was also associated with a significantly longer average length of stay (24.6 vs 10.2 days), higher average charges ($191,000 vs $92,000), and a higher percentage of discharges to intermediate-care facilities.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Hyponatremia commonly occurs with resection of intracranial malignant tumors, especially for lesions located in the deep brain and in patients with obstructive hydrocephalus. Hyponatremia was associated with higher morbidity. Further research is needed to develop targeted monitoring and intervention strategies to decrease perioperative hyponatremia and to determine if this could decrease the number of complications in this specialized population.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2012.1.peds11465","type":"journal-article","created":{"date-parts":[[2012,4,30]],"date-time":"2012-04-30T15:27:39Z","timestamp":1335799659000},"page":"524-529","source":"Crossref","is-referenced-by-count":30,"title":["Hyponatremia with intracranial malignant tumor resection in children"],"prefix":"10.3171","volume":"9","author":[{"given":"Cydni","family":"Williams","sequence":"first","affiliation":[{"name":"Departments of Pediatric Critical Care and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara D.","family":"Simon","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Seattle Children's Hospital and University of Washington School of Medicine, Seattle, Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay","family":"Riva-Cambrin","sequence":"additional","affiliation":[{"name":"Neurosurgery, University of Utah School of Medicine, Salt Lake City, Utah; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan L.","family":"Bratton","sequence":"additional","affiliation":[{"name":"Departments of Pediatric Critical Care and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-0090524","series-title":"J Neurol Sci","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/S0022-510X(97)00133-0","article-title":"Severe hyponatremia as poor prognostic factor in childhood neurologic diseases","volume":"151","author":"Al-Zahraa Omar","year":"1997"},{"key":"b2-0090524","series-title":"Eur J Endocrinol","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1530\/eje.1.02299","article-title":"Effect of exogenous glucocorticoid on osmotically stimulated antidiuretic hormone secretion and on water reabsorption in man","volume":"155","author":"B\u00e4hr","year":"2006"},{"key":"b3-0090524","series-title":"Pediatr Crit Care Med","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1097\/00130478-200207000-00005","article-title":"Acute severe asthma: outcome and Medicaid insurance","volume":"3","author":"Bratton","year":"2002"},{"key":"b4-0090524","series-title":"Childs Nerv Syst","first-page":"58","article-title":"Hyponatraemia in children with acute CNS disease: SIADH or cerebral salt wasting?","volume":"17","author":"Bussmann","year":"2001"},{"key":"b5-0090524","series-title":"CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2004\u20132007","author":"Central Brain Tumor Registry of the United States","year":"2011"},{"key":"b6-0090524","series-title":"Pediatr Cardiol","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s00246-002-0243-z","article-title":"Risk of death for Medicaid recipients undergoing congenital heart surgery","volume":"24","author":"DeMone","year":"2003"},{"key":"b7-0090524","series-title":"Eur J Endocrinol","first-page":"609","article-title":"Severe hyponatremia due to hypopituitarism with adrenal insufficiency: report on 28 cases","volume":"148","author":"Diederich","year":"2003"},{"key":"b8-0090524","series-title":"Design of the HCUP KIDS' Inpatient Database (KID)","author":"Healthcare Cost and Utilization Project","year":"2003"},{"key":"b9-0090524","series-title":"Final Report on Calculating Nationwide Inpatient Sample (NIS) Variances, 2001 HCUP Methods Series Report #2003-2","author":"Houchens"},{"key":"b10-0090524","series-title":"Pediatr Neurol","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.pediatrneurol.2006.05.004","article-title":"Cerebral salt wasting syndrome in children with acute central nervous system injury","volume":"35","author":"Jim\u00e9nez","year":"2006"},{"key":"b11-0090524","series-title":"Pediatrics","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1542\/peds.109.1.40","article-title":"Social factors associated with prolonged hospitalization among diabetic children","volume":"109","author":"Keenan","year":"2002"},{"key":"b12-0090524","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"555","DOI":"10.3171\/2008.9.JNS08191","article-title":"Incidence, clinical manifestations, and course of water and electrolyte metabolism disturbances following transsphenoidal pituitary adenoma surgery: a prospective observational study. 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