{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T16:08:11Z","timestamp":1789229291033,"version":"build-2803163510"},"reference-count":19,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:p>Deafferentation facial pain (anesthesia dolorosa) can occur after injury of the first-order trigeminal nerve. It is often debilitating and difficult to treat. The authors report the treatment of anesthesia dolorosa in a 69-year-old man with a 7-year history of pain. The pain occurred after an open resection of a right trigeminal neuroma. After treatment with medications failed, the patient was treated with nucleus caudalis (dorsal root entry zone) lesioning. His facial pain was immediately and completely eliminated. The authors describe the technique of this central neuroablative procedure, and they review the available literature regarding this procedure as well as the current evidence base for neuromodulatory surgeries. After the 1-year follow-up, the authors conclude that the patient attained lasting relief.<\/jats:p>","DOI":"10.3171\/2012.11.jns121395","type":"journal-article","created":{"date-parts":[[2012,12,14]],"date-time":"2012-12-14T15:01:20Z","timestamp":1355497280000},"page":"534-538","source":"Crossref","is-referenced-by-count":9,"title":["Nucleus caudalis dorsal root entry zone lesioning for the treatment of anesthesia dolorosa"],"prefix":"10.3171","volume":"118","author":[{"given":"Stephen E.","family":"Sandwell","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr O.","family":"El-Naggar","sequence":"additional","affiliation":[{"name":"Lake Cumberland Neurosurgical Clinic, Somerset, Kentucky"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"Suppl 2","key":"b1-jns121395","series-title":"Neurol Sci","doi-asserted-by":"publisher","first-page":"S138","DOI":"10.1007\/s10072-007-0767-3","article-title":"Update on neurosurgical treatment of chronic trigeminal autonomic cephalalgias and atypical facial pain with deep brain stimulation of posterior hypothalamus: results and comments","volume":"28","author":"Broggi","year":"2007"},{"key":"b2-jns121395","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1227\/01.NEU.0000148905.75845.98","article-title":"Motor cortex stimulation for central and neuropathic facial pain: a prospective study of 10 patients and observations of enhanced sensory and motor function during stimulation","volume":"56","author":"Brown","year":"2005"},{"key":"b3-jns121395","series-title":"Stereotact Funct Neurosurg","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1159\/000099918","article-title":"The caudalis DREZ for facial pain","volume":"68","author":"Bullard","year":"1997"},{"key":"b4-jns121395","series-title":"Eur J Neurol","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1111\/j.1468-1331.2007.01916.x","article-title":"EFNS guidelines on neurostimulation therapy for neuropathic pain","volume":"14","author":"Cruccu","year":"2007"},{"key":"b5-jns121395","series-title":"Neurosurgical Operative Atlas: Functional Neurosurgery","first-page":"112","article-title":"Nucleus caudalis dorsal root entry zone lesioning for intractable facial pain","author":"El-Naggar","year":"2008"},{"key":"b6-jns121395","series-title":"Neurosurgery","first-page":"4047","article-title":"Trigeminal nucleus caudalis lesioning for pain relief","volume":"Vol 3","author":"El-Naggar","year":"1996"},{"key":"b7-jns121395","series-title":"Acta Neurochir Suppl","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1007\/978-3-7091-9419-5_28","article-title":"The Duke experience with the nucleus caudalis DREZ operation","volume":"64","author":"Gorecki","year":"1995"},{"issue":"1 Suppl 1","key":"b8-jns121395","series-title":"Neurosurgery","first-page":"ONS147","article-title":"Computed tomography-guided percutaneous trigeminal tractotomy-nucleotomy","volume":"63","author":"Kanpolat","year":"2008"},{"key":"b9-jns121395","series-title":"The DREZ Operation","first-page":"159","article-title":"The microsurgical trigeminal caudalis nucleus DREZ procedure","author":"Nashold","year":"1996"},{"key":"b10-jns121395","series-title":"Trigeminal Neuralgia","first-page":"223","article-title":"Anesthesia dolorosa and the trigeminal caudalis nucleus DREZ operation","author":"Nashold","year":"1990"},{"key":"b11-jns121395","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.3171\/jns.1994.80.6.1116","article-title":"A new design of radiofrequency lesion electrodes for use in the caudalis nucleus DREZ operation. 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