{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T15:38:09Z","timestamp":1762875489218},"reference-count":30,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["SPI"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:p>Hyperhidrosis is caused by a sympathetic dysfunction of the central or peripheral nervous system. Intramedullary spinal cord lesions can be a cause of hyperhidrosis. The authors report a rare case of intramedullary thoracic spinal cord ganglioglioma presenting as hyperhidrosis. This 16-year-old boy presented with abnormal sweating on the right side of the neck, chest, and the right arm that had been occurring for 6 years. Neurological examination revealed mild motor weakness of the right lower extremity and slightly decreased sensation in the left lower extremity. Hyperhidrosis was observed in the right C3\u2013T8 dermatomes. Magnetic resonance imaging showed an intramedullary tumor at the right side of the spinal cord at the T2\u20133 level. The tumor showed partial enhancement after Gd administration. The patient underwent removal of the tumor via hemilaminectomy of T2\u20133. Only subtotal resection was achieved because the margins of the tumor were unclear. Histopathological examination revealed ganglioglioma. Hyperhidrosis gradually improved after surgery. Hyperhidrosis is a rare clinical manifestation of intramedullary spinal cord tumors, and only a few cases have been reported in the literature. The location of the tumor origin, around the right gray matter of the lateral spinal cord, may account for the hyperhidrosis as the initial symptom in this patient. Physicians should examine the spinal cord using MRI studies when a patient has hyperhidrosis with some motor or sensory symptoms of the extremities.<\/jats:p>","DOI":"10.3171\/2012.11.spine12530","type":"journal-article","created":{"date-parts":[[2012,11,30]],"date-time":"2012-11-30T15:07:50Z","timestamp":1354288070000},"page":"184-188","source":"Crossref","is-referenced-by-count":12,"title":["Intramedullary spinal cord ganglioglioma presenting as hyperhidrosis: unique symptoms and magnetic resonance imaging findings"],"prefix":"10.3171","volume":"18","author":[{"given":"Tomohiro","family":"Murakami","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izumi","family":"Koyanagi","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahisa","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Yoneta","sequence":"additional","affiliation":[{"name":"Dermatology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiko","family":"Keira","sequence":"additional","affiliation":[{"name":"Surgical Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Wanibuchi","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Surgical Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhiro","family":"Mikuni","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-spine12530","series-title":"Neurol India","first-page":"390","article-title":"An intramedullary tumor presenting with hyperhidrosis","volume":"52","author":"Chatterjee","year":"2004"},{"key":"b2-spine12530","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"177","DOI":"10.3171\/jns.1986.65.2.0177","article-title":"Intracerebral ganglioglioma","volume":"65","author":"Demierre","year":"1986"},{"key":"b3-spine12530","series-title":"J Neurosurg Spine","doi-asserted-by":"publisher","first-page":"445","DOI":"10.3171\/2009.4.SPINE09333","article-title":"Posttraumatic spinal cord tethering and syringomyelia: surgical treatment and long-term outcome. Clinical article","volume":"11","author":"Falci","year":"2009"},{"key":"b4-spine12530","series-title":"Childs Brain","first-page":"339","article-title":"Gangliogliomas in children. A clinicopathological study","volume":"4","author":"Garrido","year":"1978"},{"key":"b5-spine12530","series-title":"Paraplegia","first-page":"423","article-title":"Hyperhidrosis as the presenting symptom in post-traumatic syringomyelia","volume":"32","author":"Glasauer","year":"1994"},{"key":"b6-spine12530","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1097\/00006123-199712000-00038","article-title":"Ganglioglioma of the spinal cord: report of two rare cases and review of the literature","volume":"41","author":"Hamburger","year":"1997"},{"key":"b7-spine12530","series-title":"J Anat Physiol","first-page":"403","article-title":"The caudal limit of the lumbar visceral efferent nerves in man","volume":"32","author":"Harman","year":"1898"},{"key":"b8-spine12530","series-title":"Neurosurg Rev","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1007\/s10143-005-0383-8","article-title":"Intramedullary spinal cord gangliocytoma: case report and a review of the literature","volume":"28","author":"Jacob","year":"2005"},{"key":"b9-spine12530","series-title":"J Neurooncol","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1023\/B:NEON.0000024747.66993.26","article-title":"Spinal cord gangliogliomas: a review of 56 patients","volume":"68","author":"Jallo","year":"2004"},{"key":"b10-spine12530","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"58","DOI":"10.3171\/jns.1981.54.1.0058","article-title":"Gangliogliomas: pathological and clinical correlation","volume":"54","author":"Johannsson","year":"1981"},{"key":"b11-spine12530","series-title":"Am J Phys Med","first-page":"1","article-title":"Autonomic dysreflexia in traumatic myelopathy","volume":"59","author":"Kewalramani","year":"1980"},{"key":"b12-spine12530","series-title":"Surg Neurol","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.surneu.2006.10.067","article-title":"An upper thoracic spinal cord tumor presenting as hemifacial hyperhidrosis","volume":"68","author":"Kilin\u00e7er","year":"2007"},{"issue":"334","key":"b13-spine12530","series-title":"Clin Orthop Relat Res","first-page":"190","article-title":"Posttraumatic syringomyelia: a review of 21 cases","author":"Kramer","year":"1997"},{"key":"b14-spine12530","series-title":"Arch Neurol Psychiatry","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1001\/archneurpsyc.1938.02270060118005","article-title":"Sweat secretion in man. I. Sweating responses in normal persons","volume":"39","author":"List","year":"1938"},{"key":"b15-spine12530","series-title":"Arch Neurol Psychiatry","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1001\/archneurpsyc.1938.02270070037003","article-title":"Sweat secretion in man. II. Anatomic distribution of disturbances in sweating associated with lesions of the sympathetic nervous system","volume":"40","author":"List","year":"1938"},{"key":"b16-spine12530","series-title":"Arch Neurol Psychiatry","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1001\/archneurpsyc.1938.02270090037002","article-title":"Sweat secretion in man. IV. Sweat secretion of the face and its disturbances","volume":"40","author":"List","year":"1938"},{"key":"b17-spine12530","series-title":"Spinal Cord","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/sc.2008.69","article-title":"\u2018Intramedullary cervical spinal cord ganglioglioma, review of the literature and therapeutic controversies\u2019","volume":"47","author":"Lotfinia","year":"2009"},{"key":"b18-spine12530","series-title":"Pediatr Neurosurg","first-page":"310","article-title":"Ganglioglioma in children. A review of 32 cases at the University of Florida","volume":"18","author":"Mickle","year":"1992"},{"key":"b19-spine12530","series-title":"J Neurol Neurosurg Psychiatry","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1136\/jnnp.50.10.1253","article-title":"The location of descending fibres to sympathetic preganglionic vasomotor and sudomotor neurons in man","volume":"50","author":"Nathan","year":"1987"},{"key":"b20-spine12530","series-title":"Pathol Res Pract","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/S0344-0338(11)80091-9","article-title":"Spinal cord ganglioglioma in childhood","volume":"189","author":"Park","year":"1993"},{"key":"b21-spine12530","series-title":"AJNR Am J Neuroradiol","first-page":"879","article-title":"MR of spinal cord ganglioglioma","volume":"19","author":"Patel","year":"1998"},{"key":"b22-spine12530","series-title":"J Anat","first-page":"12","article-title":"Sympathetic rami in man","volume":"80","author":"Pick","year":"1946"},{"key":"b23-spine12530","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1007\/BF00300792","article-title":"Gangliogliomas in childhood","volume":"8","author":"Smith","year":"1992"},{"key":"b24-spine12530","series-title":"Arch Phys Med Rehabil","first-page":"544","article-title":"Management of reflex sweating in spinal cord injured patients","volume":"70","author":"Staas","year":"1989"},{"key":"b25-spine12530","series-title":"Paraplegia","first-page":"282","article-title":"The significance of hyperhidrosis in patients with post-traumatic syringomyelia","volume":"20","author":"Stanworth","year":"1982"},{"key":"b26-spine12530","series-title":"J Neurol Neurosurg Psychiatry","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1136\/jnnp.67.1.106","article-title":"Focal (segmental) dyshidrosis in syringomyelia","volume":"67","author":"Sudo","year":"1999"},{"key":"b27-spine12530","series-title":"J Neurol","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/BF00858720","article-title":"Segmental hyperhidrosis in syringomyelia with Chiari malformation","volume":"240","author":"Sudou","year":"1993"},{"key":"b28-spine12530","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1227\/00006123-198308000-00003","article-title":"Cerebral gangliogliomas during childhood","volume":"13","author":"Sutton","year":"1983"},{"key":"b29-spine12530","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1007\/s00381-005-0038-7","article-title":"Unilateral occipital hyperhidrosis following Chiari I decompression: case report and a review of the literature","volume":"22","author":"Tubbs","year":"2006"},{"key":"b30-spine12530","series-title":"Childs Nerv Syst","first-page":"63","article-title":"Temporal lobe gangliogliomas in children","volume":"2","author":"Ventureyra","year":"1986"}],"container-title":["Journal of Neurosurgery: Spine"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-spine\/18\/2\/article-p184.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-spine\/18\/2\/article-p184.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-spine\/18\/2\/article-p184.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,16]],"date-time":"2023-04-16T00:25:46Z","timestamp":1681604746000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-spine\/18\/2\/article-p184.xml"}},"subtitle":["Case report"],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":30,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3171\/2012.11.spine12530","relation":{},"ISSN":["1547-5654"],"issn-type":[{"value":"1547-5654","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]}}}