{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T00:43:57Z","timestamp":1768092237925,"version":"3.49.0"},"reference-count":10,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:p>Hypophosphatemia with osteomalacia may be due to a neoplasm that produces fibroblast growth factor 23 (FGF-23), which inhibits phosphate reabsorption in the kidneys. Most of these tumors occur in bone or soft tissue and occasionally in the head, although intracranial occurrence is very rare. This report describes a tumor that caused hypophosphatemia and osteomalacia and was located entirely in the right anterior cranial fossa. Radiologically, the tumor resembled a meningioma; histologically, it was a low-grade phosphaturic mesenchymal tumor, mixed connective tissue variant (PMTMCT). After gross-total resection, the patient's symptoms abated and laboratory values normalized. The authors also studied another PMTMCT initially diagnosed as a hemangiopericytoma that involved the left anterior cranial fossa and ethmoid sinus, and reviewed reports of 6 other intracranial tumors that induced osteomalacia, 3 entirely in the anterior cranial fossa, 2 involving the anterior cranial fossa and ethmoid sinus, and 1 in the cavernous sinus. In older children or adults who have hypophosphatemia with osteomalacia and no personal or family history of metabolic, renal, or malabsorptive disease, a neoplasm should be suspected and an imaging workup that includes the brain is warranted, with particular attention to the anterior cranial fossa. Additionally, because there are some overlapping histological features between PMTMCTs and hemangiopericytomas, it may be helpful to assess tumoral <jats:italic>FGF-23<\/jats:italic> expression by reverse transcriptase polymerase chain reaction or immunohistochemical analysis in patients with oncogenic osteomalacia from an intracranial tumor diagnosed as, or resembling, hemangiopericytoma.<\/jats:p>","DOI":"10.3171\/2012.12.jns12598","type":"journal-article","created":{"date-parts":[[2013,1,25]],"date-time":"2013-01-25T15:02:45Z","timestamp":1359126165000},"page":"903-907","source":"Crossref","is-referenced-by-count":28,"title":["Intracranial phosphaturic mesenchymal tumors"],"prefix":"10.3171","volume":"118","author":[{"given":"Derek A.","family":"Mathis","sequence":"first","affiliation":[{"name":"Division of Neuropathology,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward J.","family":"Stehel","sequence":"additional","affiliation":[{"name":"Departments of Radiology and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph E.","family":"Beshay","sequence":"additional","affiliation":[{"name":"Neurosurgery, The University of Texas Southwestern Medical Center, Dallas, Texas and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce E.","family":"Mickey","sequence":"additional","affiliation":[{"name":"Neurosurgery, The University of Texas Southwestern Medical Center, Dallas, Texas and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew L.","family":"Folpe","sequence":"additional","affiliation":[{"name":"Division of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack","family":"Raisanen","sequence":"additional","affiliation":[{"name":"Division of Neuropathology,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-jns12598","series-title":"J Bone Miner Res","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1002\/jbmr.316","article-title":"Selective venous catheterization for the localization of phosphaturic mesenchymal tumors","volume":"26","author":"Andreopoulou","year":"2011"},{"key":"b2-jns12598","series-title":"Am J Surg Pathol","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1097\/PAS.0b013e3181aa2311","article-title":"RT-PCR analysis for FGF23 using paraffin sections in the diagnosis of phosphaturic mesenchymal tumors with and without known tumor induced osteomalacia","volume":"33","author":"Bahrami","year":"2009"},{"key":"b3-jns12598","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"288","DOI":"10.3171\/jns.1996.84.2.0288","article-title":"Oncogenic osteomalacia associated with a meningeal phosphaturic mesenchymal tumor. 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