{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:24:55Z","timestamp":1792214695690,"version":"4.4.0"},"reference-count":68,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p>Five percent of the general population has olfactory or gustatory disorders, although most do not complain about it. However, in some cases, these symptoms can be disabling and may affect quality of life. Anosmia was reported as a possible complication following head injury and neurosurgical procedures, particularly after the resection of tumors located in the anterior fossa and the treatment of aneurysms in the anterior circulation. Nonetheless, in all of these situations, olfactory dysfunction could be explained by damage to the peripheral olfactory system.<\/jats:p>\n<jats:p>Here, the authors report a case of complete anosmia associated with ageusia following awake resection of a low-grade glioma involving the left temporoinsular region, with no recovery during a follow-up of 3 years. The frontal lobe was not retracted, and the olfactory tract was not visualized during surgery; therefore, postoperative anosmia and ageusia are likely explained by damage to the cortex and central pathways responsible for these senses. The authors suggest that the patient might have had a subclinical right hemianosmia before surgery, which is a common condition. After resection of the central structures critical for smell and taste processing in the left hemisphere, the patient could have finally had bilateral and complete olfactory and gustatory loss.<\/jats:p>\n<jats:p>This is the first known report of permanent anosmia and ageusia following glioma surgery. Because these symptoms might have been underestimated, more attention should be devoted to olfaction and taste, especially with regard to possible subclinical preoperative deficit.<\/jats:p>","DOI":"10.3171\/2012.2.jns111982","type":"journal-article","created":{"date-parts":[[2012,3,5]],"date-time":"2012-03-05T07:31:03Z","timestamp":1330932663000},"page":"1007-1013","source":"Crossref","is-referenced-by-count":10,"title":["Permanent anosmia and ageusia after resection of a left temporoinsular low-grade glioma: anatomofunctional considerations"],"prefix":"10.3171","volume":"116","author":[{"given":"Eduardo Santamaria Carvalhal","family":"Ribas","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Hospital das Clinicas of the University of S\u00e3o Paulo, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugues","family":"Duffau","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Gui de Chauliac Hospital; and"},{"name":"Institute for Neuroscience of Montpellier, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 1051, Team \u201cPlasticity of Central Nervous System, Human Stem Cells and Glial Tumors,\u201d Montpellier University Medical Center, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-jns111982","series-title":"J Cogn Neurosci","first-page":"238","article-title":"Incomplete gustatory lateralization as shown by analysis of taste discrimination after callosotomy","volume":"12","author":"Aglioti","year":"2000"},{"key":"b2-jns111982","series-title":"Neuroscience","first-page":"841","article-title":"Organization of cortical afferent input to orbitofrontal areas in the rhesus monkey","volume":"56","author":"Barbas","year":"1993"},{"key":"b3-jns111982","series-title":"J Comp Neurol","first-page":"259","article-title":"The nucleus of the solitary tract in the monkey: projections to the thalamus and brain stem nuclei","volume":"190","author":"Beckstead","year":"1980"},{"key":"b4-jns111982","series-title":"Laryngoscope","first-page":"733","article-title":"Prevalence of olfactory dysfunction: the sk\u00f6vde population-based study","volume":"114","author":"Br\u00e4merson","year":"2004"},{"key":"b5-jns111982","series-title":"Neurosci Lett","first-page":"91","article-title":"Quality of odor and olfactory lateralization processes in humans","volume":"316","author":"Brand","year":"2001"},{"key":"b6-jns111982","series-title":"J Comp Neurol","first-page":"403","article-title":"Central olfactory connections in the macaque monkey","volume":"346","author":"Carmichael","year":"1994"},{"key":"b7-jns111982","series-title":"Neuroimage","first-page":"77","article-title":"Virtual in vivo interactive dissection of white matter fasciculi in the human brain","volume":"17","author":"Catani","year":"2002"},{"key":"b8-jns111982","series-title":"Neurology","first-page":"1950","article-title":"Strokes restricted to the insular cortex","volume":"59","author":"Cereda","year":"2002"},{"key":"b9-jns111982","series-title":"Ann N Y Acad Sci","first-page":"575","article-title":"Functional lateralization of human gustatory cortex related to handedness disclosed by fMRI study","volume":"855","author":"Cerf","year":"1998"},{"key":"b10-jns111982","series-title":"Chem Senses","first-page":"625","article-title":"fMRI activation in response to odorants orally delivered in aqueous solutions","volume":"26","author":"Cerf-Ducastel","year":"2001"},{"key":"b11-jns111982","series-title":"Arch Otolaryngol Head Neck Surg","first-page":"519","article-title":"Smell and taste disorders, a study of 750 patients from the University of Pennsylvania Smell and Taste Center","volume":"117","author":"Deems","year":"1991"},{"key":"b12-jns111982","series-title":"Ann Neurol","first-page":"7","article-title":"The olfactory vector hypothesis of neurodegenerative disease: is it viable?","volume":"63","author":"Doty","year":"2008"},{"key":"b13-jns111982","series-title":"Lancet Neurol","first-page":"476","article-title":"Lessons from brain mapping in surgery for lowgrade glioma: insights into associations between tumour and brain plasticity","volume":"4","author":"Duffau","year":"2005"},{"key":"b14-jns111982","series-title":"J Neurosurg","first-page":"696","article-title":"A personal consecutive series of surgically treated 51 cases of insular WHO Grade II glioma: advances and limitations. 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