{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T05:46:15Z","timestamp":1792129575723,"version":"4.4.0"},"reference-count":23,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:sec>\n<jats:title>Object<\/jats:title>\n<jats:p>The goal of this study was to evaluate short- and long-term benefits in quality of life (QOL) after unilateral deep brain stimulation (DBS) for essential tremor (ET).<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Patients who received unilateral DBS of the ventral intermediate nucleus of the thalamus between 1997 and 2010 and who had at least 1 follow-up evaluation at least 1 year after surgery were included. Their QOL was assessed with the Parkinson Disease Questionnaire-39 (PDQ-39), and ET was measured with the Fahn-Tolosa-Marin tremor rating scale (TRS) prior to surgery and then postoperatively with the stimulation in the on mode.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Ninety-one patients (78 at 1 year; 42 at 2\u20137 years [mean 4 years]; and 22 at &gt; 7\u201312 years [mean 9 years]) were included in the analysis. The TRS total, targeted tremor, and activities of daily living (ADL) scores were significantly improved compared with presurgical scores up to 12 years. The PDQ-39 ADL, emotional well-being, stigma, and total scores were significantly improved up to 7 years after surgery compared with presurgical scores. At the longest follow-up, only the PDQ-39 stigma score was significantly improved, and the PDQ-39 mobility score was significantly worsened.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Unilateral thalamic stimulation significantly reduces ET and improves ADL scores for up to 12 years after surgery, as measured by the TRS. The PDQ-39 total score and the domains of ADL, emotional well-being, and stigma were significantly improved up to 7 years. Although scores were improved compared with presurgery, other than stigma, these benefits did not remain significant at the longest (up to 12 years) follow-up, probably related in part to changes due to aging and comorbidities.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2012.3.jns112316","type":"journal-article","created":{"date-parts":[[2012,4,20]],"date-time":"2012-04-20T13:52:26Z","timestamp":1334929946000},"page":"156-161","source":"Crossref","is-referenced-by-count":60,"title":["Long-term benefits in quality of life after unilateral thalamic deep brain stimulation for essential tremor"],"prefix":"10.3171","volume":"117","author":[{"given":"Jules M.","family":"Nazzaro","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery,"},{"name":"Neurology, and"},{"name":"Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Pahwa","sequence":"additional","affiliation":[{"name":"Neurology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly E.","family":"Lyons","sequence":"additional","affiliation":[{"name":"Neurology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-jns112316","series-title":"Br J Neurosurg","first-page":"504","article-title":"Thalamic deep brain stimulation in the treatment of essential tremor: a long-term follow-up","volume":"21","author":"Blomstedt","year":"2007"},{"key":"b2-jns112316","series-title":"Acta Neurol Scand","article-title":"Non-motor features in essential tremor","author":"Chandran","year":"2011"},{"issue":"Suppl 3","key":"b3-jns112316","series-title":"Mov Disord","first-page":"2","article-title":"Consensus statement of the Movement Disorder Society on tremor","volume":"13","author":"Deuschl","year":"1998"},{"key":"b4-jns112316","series-title":"J Neurol Neurosurg Psychiatry","first-page":"1188","article-title":"The effect of deep brain stimulation on quality of life in movement disorders","volume":"76","author":"Diamond","year":"2005"},{"key":"b5-jns112316","series-title":"Parkinson's Disease and Movement Disorders","first-page":"225","article-title":"Clinical rating scale for tremor","author":"Fahn","year":"1988"},{"key":"b6-jns112316","series-title":"J Neurol Neurosurg Psychiatry","first-page":"305","article-title":"Neuropsychological and quality of life outcomes 12 months after unilateral thalamic stimulation for essential tremor","volume":"74","author":"Fields","year":"2003"},{"key":"b7-jns112316","series-title":"Acta Neurol Scand","first-page":"387","article-title":"Long-term effect of deep brain stimulation for essential tremor on activities of daily living and health-related quality of 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Stereotactic and Functional Neurosurgery, ed 2","first-page":"1743","article-title":"Management of essential tremor","author":"Nazzaro","year":"2009"},{"key":"b17-jns112316","series-title":"Acta Neurol Scand","first-page":"289","article-title":"Quality of life in a random sample of community dwelling older patients with essential tremor","volume":"116","author":"Nguyen","year":"2007"},{"key":"b18-jns112316","series-title":"J Neurosurg","first-page":"506","article-title":"Long-term evaluation of deep brain stimulation of the thalamus","volume":"104","author":"Pahwa","year":"2006"},{"key":"b19-jns112316","series-title":"Qual Life Res","first-page":"241","article-title":"The development and validation of a short measure of functioning and well being for individuals with Parkinson's disease","volume":"4","author":"Peto","year":"1995"},{"key":"b20-jns112316","series-title":"Mov Disord","first-page":"163","article-title":"Long-term efficacy of thalamic deep brain stimulation for tremor: double-blind assessments","volume":"18","author":"Rehncrona","year":"2003"},{"key":"b21-jns112316","series-title":"J Neurol Neurosurg Psychiatry","first-page":"1387","article-title":"Multicentre European study of thalamic stimulation in essential tremor: a six year follow up","volume":"74","author":"Sydow","year":"2003"},{"key":"b22-jns112316","series-title":"Parkinsonism Relat Disord","first-page":"367","article-title":"Quality of life in Essential Tremor Questionnaire (QUEST): development and initial validation","volume":"11","author":"Tr\u00f6ster","year":"2005"},{"key":"b23-jns112316","series-title":"J Neurosurg","first-page":"1271","article-title":"Long-term results of thalamic deep brain stimulation for essential tremor. 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