{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:59:46Z","timestamp":1790823586901,"version":"4.1.0"},"reference-count":20,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PED"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:sec>\n<jats:title>Object<\/jats:title>\n<jats:p>Corpus callosotomy is usually intended to alleviate\u2014not to achieve total control of\u2014epileptic seizures. A few patients experience complete seizure control after callosotomy, but the associated clinical factors are unknown. The object of this study was to investigate clinical factors associated with long-term seizure remission after total corpus callosotomy in patients with infantile or early childhood onset epilepsy.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Thirteen consecutive patients with infantile or early childhood onset epilepsy underwent 1-stage total corpus callosotomy for alleviation of seizures. Their age at surgery ranged from 1 year and 5 months to 24 years (median 7 years). Eleven patients had West syndrome at the onset of disease, and the other 2 had Lennox-Gastaut syndrome. All patients suffered from spasms, axial tonic seizures, or atonic seizures. Six patients had proven etiology of epilepsy, including tuberous sclerosis, polymicrogyria, trauma, and Smith-Magenis syndrome. The association between postoperative seizure freedom and preoperative factors including age at surgery, no MRI abnormalities, proven etiology, and focal electroencephalographic epileptiform discharges was examined.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Postoperative seizure freedom was achieved in 4 of 13 patients for a minimum of 12 months. All 4 patients had no MRI abnormalities and no identified etiology. None of the 8 patients with MRI abnormality, 6 patients with known etiology of epilepsy, or 4 patients aged older than 10 years at surgery achieved seizure freedom. Two of the 7 patients with focal electroencephalographic abnormalities became seizure free. Absence of MRI abnormalities was significantly associated with postoperative seizure freedom (p &lt; 0.01).<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Complete seizure remission is achieved after total corpus callosotomy in a subgroup of patients with intractable epilepsy following West syndrome or Lennox-Gastaut syndrome. One-stage total corpus callosotomy at a young age may provide a higher rate of seizure freedom, especially for patients with no MRI abnormalities and no identified etiology of epilepsy.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2012.3.peds11544","type":"journal-article","created":{"date-parts":[[2012,6,8]],"date-time":"2012-06-08T14:04:39Z","timestamp":1339164279000},"page":"7-13","source":"Crossref","is-referenced-by-count":39,"title":["Complete remission of seizures after corpus callosotomy"],"prefix":"10.3171","volume":"10","author":[{"given":"Masaki","family":"Iwasaki","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsugu","family":"Uematsu","sequence":"additional","affiliation":[{"name":"Pediatrics, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Sato","sequence":"additional","affiliation":[{"name":"Pediatrics, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tojo","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Pediatrics, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Haginoya","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology, Takuto Rehabilitation Center for Children, Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-ichiro","family":"Osawa","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Itabashi","sequence":"additional","affiliation":[{"name":"Epileptology, Tohoku University Graduate School of Medicine; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazutaka","family":"Jin","sequence":"additional","affiliation":[{"name":"Epileptology, Tohoku University Graduate School of Medicine; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobukazu","family":"Nakasato","sequence":"additional","affiliation":[{"name":"Epileptology, Tohoku University Graduate School of Medicine; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teiji","family":"Tominaga","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-peds11544","series-title":"Epilepsy Behav","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.yebeh.2010.06.044","article-title":"Vagus nerve stimulation for drop attacks in a pediatric population","volume":"19","author":"Abd-El-Barr","year":"2010"},{"key":"b2-peds11544","series-title":"Epilepsia","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1111\/j.1528-1167.2006.00430.x","article-title":"Extended, one-stage callosal section for treatment of refractory secondarily generalized epilepsy in patients with Lennox-Gastaut and Lennox-like syndromes","volume":"47","author":"Cukiert","year":"2006"},{"key":"b3-peds11544","series-title":"Clin Neurophysiol","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.1016\/j.clinph.2011.04.013","article-title":"Lateralization of interictal spikes after corpus callosotomy","volume":"122","author":"Iwasaki","year":"2011"},{"key":"b4-peds11544","series-title":"J Neurosurg Pediatr","doi-asserted-by":"publisher","first-page":"257","DOI":"10.3171\/2010.5.PEDS1029","article-title":"Complete versus anterior two-thirds corpus callosotomy in children: analysis of outcome. 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