{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:52:13Z","timestamp":1790628733728,"version":"4.1.0"},"reference-count":16,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:sec>\n<jats:title>Object<\/jats:title>\n<jats:p>Familial predisposition is a recognized nonmodifiable risk factor for the formation and rupture of intracranial aneurysms (IAs). However, data regarding the characteristics of familial IAs are limited. The authors sought to describe familial IAs more fully, and to compare their characteristics with a large cohort of nonfamilial IAs.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>The Familial Intracranial Aneurysm (FIA) study is a multicenter international study with the goal of identifying genetic and other risk factors for formation and rupture of IAs in a highly enriched population. The authors compared the FIA study cohort with the International Study of Unruptured Intracranial Aneurysms (ISUIA) cohort with regard to patient demographic data, IA location, and IA multiplicity. To improve comparability, all patients in the ISUIA who had a family history of IAs or subarachnoid hemorrhage were excluded, as well as all patients in both cohorts who had a ruptured IA prior to study entry.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Of 983 patients enrolled in the FIA study with definite or probable IAs, 511 met the inclusion criteria for this analysis. Of the 4059 patients in the ISUIA study, 983 had a previous IA rupture and 657 of the remainder had a positive family history, leaving 2419 individuals in the analysis. Multiplicity was more common in the FIA patients (35.6% vs 27.9%, p &lt; 0.001). The FIA patients had a higher proportion of IAs located in the middle cerebral artery (28.6% vs 24.9%), whereas ISUIA patients had a higher proportion of posterior communicating artery IAs (13.7% vs 8.2%, p = 0.016).<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Heritable structural vulnerability may account for differences in IA multiplicity and location. Important investigations into the underlying genetic mechanisms of IA formation are ongoing.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2012.4.jns111822","type":"journal-article","created":{"date-parts":[[2012,4,27]],"date-time":"2012-04-27T15:07:28Z","timestamp":1335539248000},"page":"60-64","source":"Crossref","is-referenced-by-count":44,"title":["Unruptured intracranial aneurysms in the Familial Intracranial Aneurysm and International Study of Unruptured Intracranial Aneurysms cohorts: differences in multiplicity and location"],"prefix":"10.3171","volume":"117","author":[{"given":"Jason","family":"Mackey","sequence":"first","affiliation":[{"name":"Department of Neurology, Indiana University, Indianapolis, Indiana;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Brown","sequence":"additional","affiliation":[{"name":"Departments of Neurology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles J.","family":"Moomaw","sequence":"additional","affiliation":[{"name":"Departments of Neurology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Sauerbeck","sequence":"additional","affiliation":[{"name":"Departments of Neurology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Hornung","sequence":"additional","affiliation":[{"name":"Emergency Medicine, University of Cincinnati, Ohio;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dheeraj","family":"Gandhi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Johns Hopkins, Baltimore, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Woo","sequence":"additional","affiliation":[{"name":"Departments of Neurology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn","family":"Kleindorfer","sequence":"additional","affiliation":[{"name":"Departments of Neurology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew L.","family":"Flaherty","sequence":"additional","affiliation":[{"name":"Departments of Neurology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Meissner","sequence":"additional","affiliation":[{"name":"Departments of Neurology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Anderson","sequence":"additional","affiliation":[{"name":"The George Institute for International Health, University of Sydney, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Sander","family":"Connolly","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Columbia University, New York, New York;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Rouleau","sequence":"additional","affiliation":[{"name":"Notre Dame Hospital, University of Montreal, Quebec, Canada; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David F.","family":"Kallmes","sequence":"additional","affiliation":[{"name":"Radiology, Mayo Clinic, Rochester, Minnesota;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Torner","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Iowa, Iowa City, Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Huston","sequence":"additional","affiliation":[{"name":"Radiology, Mayo Clinic, Rochester, Minnesota;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph P.","family":"Broderick","sequence":"additional","affiliation":[{"name":"Departments of Neurology and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-JNS111822","series-title":"Nat Genet","first-page":"1472","article-title":"Susceptibility loci for intracranial aneurysm in European and Japanese populations","volume":"40","author":"Bilguvar","year":"2008"},{"key":"b2-JNS111822","series-title":"Stroke","first-page":"1952","article-title":"Greater rupture risk for familial as compared to sporadic unruptured intracranial aneurysms","volume":"40","author":"Broderick","year":"2009"},{"key":"b3-JNS111822","series-title":"BMC Med Genet","first-page":"17","article-title":"The Familial Intracranial Aneurysm (FIA) study protocol","volume":"6","author":"Broderick","year":"2005"},{"key":"b4-JNS111822","series-title":"Nat Genet","first-page":"217","article-title":"The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic 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Study","volume":"41","author":"Kleindorfer","year":"2010"},{"key":"b8-JNS111822","series-title":"J Neurosurg","first-page":"522","article-title":"Familial intracranial aneurysms","volume":"66","author":"Lozano","year":"1987"},{"key":"b9-JNS111822","series-title":"Stroke","first-page":"251","article-title":"Prevalence and risk of rupture of intracranial aneurysms: a systematic review","volume":"29","author":"Rinkel","year":"1998"},{"key":"b10-JNS111822","series-title":"Neurosurgery","first-page":"43","article-title":"Special features of familial intracranial aneurysms: report of 215 familial aneurysms","volume":"37","author":"Ronkainen","year":"1995"},{"key":"b11-JNS111822","series-title":"Genome Med","first-page":"61","article-title":"From GWAS to the clinic: risk factors for intracranial aneurysms","volume":"2","author":"Ruigrok","year":"2010"},{"key":"b12-JNS111822","series-title":"Stroke","first-page":"1049","article-title":"Genetics of intracranial 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