{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T13:59:12Z","timestamp":1783000752669,"version":"3.54.5"},"reference-count":19,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"Special_Suppl","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2012,12]]},"abstract":"\nObject<\/jats:title>\nThe authors evaluated the potential role of environmental risk factors, including exposure to diagnostic or therapeutic radiation and to wireless phones that emit nonionizing radiation, in the etiology of vestibular schwannoma (VS).<\/jats:p><\/jats:sec>\n\nMethods<\/jats:title>\nA total of 343 patients with VSs who underwent Gamma Knife surgery performed between 1997 and 2007 were age and sex matched to 343 control patients from the outpatient degenerative spinal disorders service at the University of Pittsburgh Medical Center. The authors obtained information on previous exposure to medical radiation, use of wireless phone technologies, and other environmental factors thought to be associated with the development of a VS. Conditional multivariate logistic regression was used to estimate adjusted odds ratios (aORs) and 95% confidence intervals (CIs).<\/jats:p><\/jats:sec>\n\nResults<\/jats:title>\nAfter adjusting for race, education, cigarette smoking, alcohol consumption, occupational exposure to noise, use of cell phones, and family history of cancer, the authors identified only a single factor that was associated with a higher risk of VS: individuals exposed to dental x-rays once a year (aOR = 2.27, 95% CI = 1.01\u20135.09) or once every 2\u20135 years (aOR = 2.65, 95% CI = 1.20\u20135.<\/jats:italic>85), compared with those exposed less than once every 5 years. Of interest, a history of exposure to radiation related to head or head-and-neck computed tomography was associated with a reduced risk of VS (aOR = 0.52, 95% CI = 0.30\u20130.90). No relationship was found between the use of cell phones or cordless phones and VS.<\/jats:p><\/jats:sec>\n\nConclusions<\/jats:title>\nPatients with acoustic neuromas reported significantly more exposure to dental x-rays than a matched cohort control group. Reducing the frequency of dental x-ray examinations may decrease the potential risk of VS.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2012.5.gks12615","type":"journal-article","created":{"date-parts":[[2018,11,16]],"date-time":"2018-11-16T00:55:40Z","timestamp":1542329740000},"page":"78-83","source":"Crossref","is-referenced-by-count":20,"title":["Are frequent dental x-ray examinations associated with increased risk of vestibular schwannoma?"],"prefix":"10.3171","volume":"117","author":[{"given":"Yueh-Ying","family":"Han","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oren","family":"Berkowitz","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh;"},{"name":"Department of Neurological Surgery, Center for Image Guided Neurological Surgery, School of Medicine, University of Pittsburgh and University of Pittsburgh Medical Center; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn","family":"Talbott","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Kondziolka","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Center for Image Guided Neurological Surgery, School of Medicine, University of Pittsburgh and University of Pittsburgh Medical Center; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryann","family":"Donovan","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, University of Pittsburgh and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Dade","family":"Lunsford","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Center for Image Guided Neurological Surgery, School of Medicine, University of Pittsburgh and University of Pittsburgh Medical Center; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-1170078","series-title":"Toxicological Profile for Ionizing Radiation","author":"Agency for Toxic Substances and Disease Registry","year":"1999"},{"key":"b2-1170078","series-title":"Br J Cancer","first-page":"1654","article-title":"Cigarette smoking and risk of acoustic neuromas and pituitary tumours in the Million Women Study","volume":"102","author":"Benson","year":"2010"},{"key":"b3-1170078","series-title":"Eur J Cancer","first-page":"1990","article-title":"Medical exposure to ionising radiation and the risk of brain tumours: Interphone study group, Germany","volume":"43","author":"Blettner","year":"2007"},{"key":"b4-1170078","series-title":"Int J Cancer","first-page":"252","article-title":"History of allergies and autoimmune diseases and risk of brain tumors in adults","volume":"99","author":"Brenner","year":"2002"},{"key":"b5-1170078","series-title":"Cancer Epidemiol","first-page":"453","article-title":"Acoustic neuroma risk in relation to mobile telephone use: results of the INTERPHONE international case-control study","volume":"35","author":"Cardis","year":"2011"},{"key":"b6-1170078","series-title":"Am J Epidemiol","first-page":"327","article-title":"Exposure to loud noise and risk of acoustic neuroma","volume":"163","author":"Edwards","year":"2006"},{"key":"b7-1170078","series-title":"Int J Oncol","first-page":"5","article-title":"Mobile phones, cordless phones and the risk for brain tumours","volume":"35","author":"Hardell","year":"2009"},{"key":"b8-1170078","series-title":"Neuro-oncol","first-page":"274","article-title":"Meningioma and schwannoma risk in adults in relation to family history of cancer","volume":"6","author":"Hill","year":"2004"},{"key":"b9-1170078","series-title":"Occup Environ Med","first-page":"480","article-title":"Can loud noise cause acoustic neuroma? Analysis of the INTERPHONE study in France","volume":"66","author":"Hours","year":"2009"},{"key":"b10-1170078","series-title":"IARC Classifies Radiofrequency Electromagnetic Fields as Possibly Carcinogenic to Humans","author":"International Agency for Research on Cancer","year":"2011"},{"key":"b11-1170078","series-title":"Am J Epidemiol","first-page":"136","article-title":"Self-reported electrical appliance use and risk of adult brain tumors","volume":"161","author":"Kleinerman","year":"2005"},{"key":"b12-1170078","series-title":"Environ Health Perspect","first-page":"316","article-title":"The controversy about a possible relationship between mobile phone use and cancer","volume":"117","author":"Kundi","year":"2009"},{"key":"b13-1170078","series-title":"Cancer","first-page":"1026","article-title":"Dental X-rays and the risk of intracranial meningioma: a population-based case-control study","volume":"100","author":"Longstreth","year":"2004"},{"key":"b14-1170078","series-title":"J Am Dent Assoc","first-page":"1237","article-title":"Patient risk related to common dental radiographic examinations: the impact of 2007 International Commission on Radiological Protection recommendations regarding dose calculation","volume":"139","author":"Ludlow","year":"2008"},{"key":"b15-1170078","series-title":"Acta Oncol","first-page":"447","article-title":"Dental x-rays and the risk of thyroid cancer: a case-control study","volume":"49","author":"Memon","year":"2010"},{"key":"b16-1170078","series-title":"Radiology","first-page":"520","article-title":"Radiologic and nuclear medicine studies in the United States and worldwide: frequency, radiation dose, and comparison with other radiation sources\u20141950\u20132007","volume":"253","author":"Mettler","year":"2009"},{"key":"b17-1170078","series-title":"J Natl Cancer Inst","first-page":"943","article-title":"Prior exposure to medical and dental x-rays related to tumors of the parotid gland","volume":"80","author":"Preston-Martin","year":"1988"},{"key":"b18-1170078","series-title":"Nature","first-page":"515","article-title":"Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2","volume":"363","author":"Rouleau","year":"1993"},{"key":"b19-1170078","series-title":"Neuroepidemiology","first-page":"234","article-title":"Are prior head injuries or diagnostic X-rays associated with glioma in adults? The effects of control selection bias","volume":"19","author":"Wrensch","year":"2000"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/117\/Special_Suppl\/article-p78.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/117\/Special_Suppl\/article-p78.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/117\/Special_Suppl\/article-p78.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T23:11:21Z","timestamp":1679872281000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/117\/Special_Suppl\/article-p78.xml"}},"subtitle":["Clinical article"],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":19,"journal-issue":{"issue":"Special_Suppl"},"URL":"https:\/\/doi.org\/10.3171\/2012.5.gks12615","relation":{},"ISSN":["0022-3085","1933-0693"],"issn-type":[{"value":"0022-3085","type":"print"},{"value":"1933-0693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12]]}}}