{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T15:22:30Z","timestamp":1794324150519,"version":"4.9.0"},"reference-count":20,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"Special_Suppl","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:sec>\n                    <jats:title>Object<\/jats:title>\n                    <jats:p>The goal of this study was to investigate the safety and efficacy of multisession Gamma Knife surgery (GKS) in the treatment of benign orbital tumors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Twenty-three patients who retained their vision despite having tumors touching their optic nerve were treated with multisession (4-fraction) GKS. The median tumor volume was 2800 mm\n                      <jats:sup>3<\/jats:sup>\n                      (range 211\u201310,800 mm\n                      <jats:sup>3<\/jats:sup>\n                      ), and the median cumulative margin dose was 20 Gy (range 18\u201322 Gy).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median clinical follow-up duration in these patients was 38 months (range 9\u201374 months). No patient experienced tumor progression in this study. In particular, a higher degree of tumor shrinkage was found in the 7 patients with cavernous hemangiomas than in patients with other types of lesions (p &lt; 0.05). Of the 23 patients whose preoperative vision was preserved, 11 showed improvement in visual acuity and\/or visual field and 12 showed stable visual acuity. No GKS-related adverse events were noted during or after treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Multisession radiosurgery using the Gamma Knife may be a good strategy for tumors in direct contact with the optic nerve. A cumulative margin dose of up to 22 Gy delivered in 4 sessions is safe for preservation of visual function with a high probability of tumor control.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2012.7.gks12780","type":"journal-article","created":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T19:55:40Z","timestamp":1542311740000},"page":"102-107","source":"Crossref","is-referenced-by-count":15,"title":["Multisession Gamma Knife surgery for benign orbital tumors"],"prefix":"10.3171","volume":"117","author":[{"given":"Kyung-Il","family":"Jo","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Seok","family":"Im","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doo-Sik","family":"Kong","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho Jun","family":"Seol","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do-Hyun","family":"Nam","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon-Duck","family":"Kim","sequence":"additional","affiliation":[{"name":"Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Il","family":"Lee","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"Suppl 2","key":"b1-1170102","series-title":"Neurosurgery","first-page":"733","article-title":"Visual field preservation after multisession cyberknife radiosurgery for perioptic lesions","volume":"62","author":"Adler","year":"2008"},{"key":"b2-1170102","series-title":"Am J Clin Oncol","first-page":"265","article-title":"Gamma knife radiosurgery for vestibular schwannomas: tumor control and functional preservation in 70 patients","volume":"34","author":"Arthurs","year":"2011"},{"key":"b3-1170102","series-title":"Radiother Oncol","first-page":"169","article-title":"Early improvements in vision after fractionated stereotactic radiotherapy for primary optic nerve sheath meningioma","volume":"72","author":"Baumert","year":"2004"},{"key":"b4-1170102","series-title":"Int J Radiat Oncol Biol Phys","first-page":"1422","article-title":"Stereotactic fractionated radiotherapy in patients with optic nerve sheath meningioma","volume":"54","author":"Becker","year":"2002"},{"key":"b5-1170102","series-title":"Curr Opin Ophthalmol","first-page":"367","article-title":"Neural orbital tumors","volume":"11","author":"Cantore","year":"2000"},{"key":"b6-1170102","series-title":"Surv Ophthalmol","first-page":"167","article-title":"Optic nerve sheath meningiomas","volume":"37","author":"Dutton","year":"1992"},{"key":"b7-1170102","series-title":"Am J Ophthalmol","first-page":"764","article-title":"Cavernous hemangioma of the orbital apex: pathogenetic considerations in surgical management","volume":"150","author":"Harris","year":"2010"},{"key":"b8-1170102","series-title":"Orbit","first-page":"97","article-title":"Treatment of intraorbital lesions using the Accuray CyberKnife system","volume":"27","author":"Hirschbein","year":"2008"},{"key":"b9-1170102","series-title":"Surg Neurol","first-page":"448","article-title":"Intraorbital meningiomas. 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