{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T15:23:02Z","timestamp":1794324182652,"version":"4.9.0"},"reference-count":15,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"Special_Suppl","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:sec>\n                    <jats:title>Object<\/jats:title>\n                    <jats:p>The aim of this study was to assess long-term clinical outcomes in patients who underwent Gamma Knife surgery (GKS) with a low margin dose\u201414 Gy or less\u2014to treat vestibular schwannoma (VS) unrelated to neurofibromatosis Type II.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Between December 1994 and December 2001, 200 patients with VSs underwent GKS, which was performed using the Leksell Gamma Knife model B. More than 10 years of follow-up is available in these patients. One hundred ninety patients (88 male and 102 female patients) were followed up using MRI (follow-up rate 95%). The mean age of these patients was 50.6 years (range 10\u201377 years). Gamma Knife surgery was the primary treatment for VS in 134 cases (70.5%) and was an adjunctive management approach in 56 cases (29.5%). The median tumor margin dose was 13.0 Gy (range 6.0\u201314.4 Gy), and the median maximum tumor dose was 28.0 Gy (range 15.0\u201360.0 Gy). The median tumor volume was 3.6 cm\n                      <jats:sup>3<\/jats:sup>\n                      (range 0.3\u201327.3 cm\n                      <jats:sup>3<\/jats:sup>\n                      ). The median duration of follow-up in these patients was 109 months (range 8\u2013195 months).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the 190 patients, the latest follow-up MRI studies demonstrated tumor regression in 122 patients (64.2%), stable tumor in 48 patients (25.3%), and tumor enlargement in 20 patients (10.5%). The total rate of tumor control was 89.5%. Using the Kaplan-Meier method, the authors found the estimated 3-, 5-, 10-, and 15-year tumor control rates to be 95%, 93%, 86%, and 79%, respectively; and the estimated 3-, 5-, and 10-year hearing preservation rates to be 96%, 92%, and 70%, respectively. Twenty-six patients (13.7%) exhibited transient mild facial palsy or facial spasm, and 2 patients (1.1%) suffered persistent mild facial palsy. Thirty-nine patients (20.5%) had transient trigeminal neuropathy, and 5 patients (2.6%) suffered from persistent mild facial numbness. The incidence of persistent severe facial and trigeminal neuropathy was 0.0%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>With a low prescribed margin dose of 14 Gy or less, GKS was confirmed to provide long-term tumor control for small to medium-sized VSs and largely to prevent cranial nerves from iatrogenic injury. Based on the findings of this study, GKS is also a reasonable option for the treatment of large, heterogeneously enhancing tumors without symptomatic brainstem compression. Gamma Knife surgery can preserve a high quality of life for most patients with VS who do not have symptomatic brainstem compression. Long-term follow-up is required because of the risk of delayed recurrence of VS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2012.7.gks12783","type":"journal-article","created":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T19:55:40Z","timestamp":1542311740000},"page":"57-62","source":"Crossref","is-referenced-by-count":42,"title":["Long-term follow-up studies of Gamma Knife surgery with a low margin dose for vestibular schwannoma"],"prefix":"10.3171","volume":"117","author":[{"given":"Shibin","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"Suppl","key":"b1-1170057","series-title":"J Neurosurg","first-page":"87","article-title":"Gamma knife surgery for vestibular schwannoma: 10-year experience of 195 cases","volume":"102","author":"Chung","year":"2005"},{"issue":"Suppl","key":"b2-1170057","series-title":"J Neurosurg","first-page":"112","article-title":"Large vestibular schwannomas treated by Gamma Knife surgery: long-term outcomes. Clinical article","volume":"113","author":"Chung","year":"2010"},{"issue":"Suppl","key":"b3-1170057","series-title":"J Neurosurg","first-page":"144","article-title":"Retreatment of vestibular schwannomas with Gamma Knife surgery","volume":"109","author":"Dewan","year":"2008"},{"key":"b4-1170057","series-title":"Neurosurgery","first-page":"257","article-title":"Stereotactic radiosurgery for vestibular schwannomas: analysis of 317 patients followed more than 5 years","volume":"57","author":"Hasegawa","year":"2005"},{"key":"b5-1170057","series-title":"J Neurosurg","first-page":"10","article-title":"Long-term outcomes in patients with vestibular schwannomas treated using gamma knife surgery: 10-year follow up","volume":"102","author":"Hasegawa","year":"2005"},{"issue":"Suppl","key":"b6-1170057","series-title":"J Neurosurg","first-page":"111","article-title":"Low-dose radiosurgery for large vestibular schwannomas: long-term results of functional preservation","volume":"102","author":"Inoue","year":"2005"},{"key":"b7-1170057","series-title":"Neurosurgery","first-page":"282","article-title":"Radiosurgery for acoustic neuromas: results of low-dose treatment","volume":"53","author":"Iwai","year":"2003"},{"issue":"Suppl","key":"b8-1170057","series-title":"J Neurosurg","first-page":"195","article-title":"Radiosurgery of vestibular schwannomas: summary of experience in 829 cases","volume":"102","author":"Lunsford","year":"2005"},{"issue":"Suppl 1","key":"b9-1170057","series-title":"Stereotact Funct Neurosurg","first-page":"65","article-title":"Long-term complications following gamma knife radiosurgery of vestibular schwannomas","volume":"70","author":"Nor\u00e9n","year":"1998"},{"key":"b10-1170057","series-title":"Acta Neurochir Suppl (Wien)","first-page":"104","article-title":"Gamma knife surgery in acoustic tumours","volume":"58","author":"Nor\u00e9n","year":"1994"},{"key":"b11-1170057","series-title":"Arch Neurol","first-page":"73","article-title":"Cranial nerve preservation after stereotactic radiosurgery for small acoustic tumors","volume":"52","author":"Ogunrinde","year":"1995"},{"key":"b12-1170057","series-title":"Cancer","first-page":"580","article-title":"Hearing preservation after gamma knife stereotactic radiosurgery of vestibular schwannoma","volume":"104","author":"Paek","year":"2005"},{"key":"b13-1170057","series-title":"J Neurosurg","first-page":"745","article-title":"Gamma surgery for vestibular schwannoma","volume":"92","author":"Prasad","year":"2000"},{"issue":"Suppl","key":"b14-1170057","series-title":"J Neurosurg","first-page":"204","article-title":"Increased preservation of functional hearing after gamma knife surgery for vestibular schwannoma","volume":"102","author":"van Eck","year":"2005"},{"issue":"Suppl","key":"b15-1170057","series-title":"J Neurosurg","first-page":"114","article-title":"Outpatient gamma knife surgery for vestibular schwannoma: definition of the therapeutic profile based on a 10-year experience","volume":"102","author":"Wowra","year":"2005"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/117\/Special_Suppl\/article-p57.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/117\/Special_Suppl\/article-p57.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/117\/Special_Suppl\/article-p57.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T19:15:27Z","timestamp":1679858127000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/117\/Special_Suppl\/article-p57.xml"}},"subtitle":["Clinical article"],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":15,"journal-issue":{"issue":"Special_Suppl"},"URL":"https:\/\/doi.org\/10.3171\/2012.7.gks12783","relation":{},"ISSN":["0022-3085","1933-0693"],"issn-type":[{"value":"0022-3085","type":"print"},{"value":"1933-0693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12]]}}}