{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T01:44:14Z","timestamp":1774316654439,"version":"3.50.1"},"reference-count":27,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PED"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:sec>\n<jats:title>Object<\/jats:title>\n<jats:p>Magnetic resonance imaging is commonly used in diagnosis and surveillance for optic pathway glioma (OPG). The authors investigated the role of diffusion tensor (DT) tractography in assessing the location of visual pathway fibers in the presence of tumor.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Data in 10 children with OPG were acquired using a 3T MRI generalized autocalibrating parallel acquisitions DT\u2013echo planar imaging sequence (25 isotropic directions with a b value of 1000 seconds\/mm<jats:sup>2<\/jats:sup>, slice thickness 3 mm). Fiber tractography was performed, with seed regions placed within the optic chiasm and bilateral nerves on the coronal plane, including the tumor and surrounding normal-appearing tissue. Tracking was performed with a curvature threshold of 30\u00b0.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>For prechiasmatic lesions, fibers either stopped abruptly at the tumor or traversed abnormally dilated nerve segments. Similar findings were seen with chiasmatic lesions, with an additional arrangement in which fibers diverged around the tumor. For each patient, DT tractography provided additional information about visual fiber arrangement in relation to the tumor that was not evident by using conventional MRI methods. Retrospective reconstruction of visual fibers in 1 patient with new postoperative hemianopia revealed an unexpected superior displacement of the optic tract that might have been helpful information had it been applied to preoperative planning or surgical navigation.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Optic pathway DT tractography is feasible in patients with OPG and provides new information about the arrangement of visual fibers in relation to tumors that could be incorporated into surgical navigation for tumor biopsy or debulking procedures.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2012.7.peds1270","type":"journal-article","created":{"date-parts":[[2012,8,17]],"date-time":"2012-08-17T13:26:50Z","timestamp":1345210010000},"page":"273-280","source":"Crossref","is-referenced-by-count":36,"title":["Application of diffusion tensor tractography in pediatric optic pathway glioma"],"prefix":"10.3171","volume":"10","author":[{"given":"Robert M.","family":"Lober","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery, Division of Pediatric Neurosurgery;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raphael","family":"Guzman","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery, Division of Pediatric Neurosurgery;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel H.","family":"Cheshier","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery, Division of Pediatric Neurosurgery;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas R.","family":"Fredrick","sequence":"additional","affiliation":[{"name":"Ophthalmology; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S. B.","family":"Edwards","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery, Division of Pediatric Neurosurgery;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristen W.","family":"Yeom","sequence":"additional","affiliation":[{"name":"Radiology, Division of Pediatric Radiology, Stanford University School of Medicine, Stanford, California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-peds1270","series-title":"Brain Pathol","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1111\/j.1750-3639.1997.tb01065.x","article-title":"Optic chiasmatic-hypothalamic glioma","volume":"7","author":"Alshail","year":"1997"},{"key":"b2-peds1270","series-title":"NMR Biomed","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1002\/nbm.783","article-title":"Diffusion-tensor MRI: theory, experimental design and data analysis\u2014a technical review","volume":"15","author":"Basser","year":"2002"},{"key":"b3-peds1270","series-title":"Int J Radiat Oncol Biol Phys","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/0360-3016(91)90678-W","article-title":"Chiasmal gliomas: results of irradiation management in 57 patients and review of literature","volume":"21","author":"Bataini","year":"1991"},{"key":"b4-peds1270","series-title":"J Neurol Neurosurg Psychiatry","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1136\/jnnp.45.2.143","article-title":"Direct demonstration of transsynaptic degeneration in the human visual system: a comparison of retrograde and anterograde changes","volume":"45","author":"Beatty","year":"1982"},{"issue":"5","key":"b5-peds1270","series-title":"Neurosurg Focus","doi-asserted-by":"publisher","first-page":"E2","DOI":"10.3171\/FOC-07\/11\/E2","article-title":"Optic pathway gliomas: a review","volume":"23","author":"Binning","year":"2007"},{"key":"b6-peds1270","series-title":"Hum Brain Mapp","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1002\/hbm.20101","article-title":"Optic radiation changes after optic neuritis detected by tractography-based group mapping","volume":"25","author":"Ciccarelli","year":"2005"},{"key":"b7-peds1270","series-title":"Neurosurg Rev","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1007\/s10143-005-0385-6","article-title":"Diffusion-weighted imaging-guided resection of intracerebral lesions involving the optic radiation","volume":"28","author":"Coenen","year":"2005"},{"key":"b8-peds1270","series-title":"Pediatr Radiol","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1007\/s00247-011-2216-y","article-title":"Magnetic resonance diffusion tensor imaging (MRDTI) of the optic nerve and optic radiations at 3T in children with neurofibromatosis type I (NF-1)","volume":"42","author":"Filippi","year":"2012"},{"key":"b9-peds1270","series-title":"Pediatr Neurosurg","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1159\/000120729","article-title":"Optic pathway\/hypothalamic gliomas: a dilemma in management","volume":"19","author":"Hoffman","year":"1993"},{"key":"b10-peds1270","series-title":"Br J Ophthalmol","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1136\/bjo.53.12.793","article-title":"Optic glioma of childhood. Natural history and rationale for conservative management","volume":"53","author":"Hoyt","year":"1969"},{"key":"b11-peds1270","series-title":"AJNR Am J Neuroradiol","doi-asserted-by":"publisher","first-page":"146","DOI":"10.3174\/ajnr.A0742","article-title":"Preliminary experience with visualization of intracortical fibers by focused high-resolution diffusion tensor imaging","volume":"29","author":"Jaermann","year":"2008"},{"key":"b12-peds1270","series-title":"Int J Radiat Oncol Biol Phys","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1016\/0360-3016(90)90418-J","article-title":"Radiation therapy for gliomas of the optic nerve and chiasm","volume":"18","author":"Kovalic","year":"1990"},{"key":"b13-peds1270","series-title":"Ann Neurol","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1002\/ana.21107","article-title":"Optic pathway gliomas in neurofibromatosis-1: controversies and recommendations","volume":"61","author":"Listernick","year":"2007"},{"key":"b14-peds1270","series-title":"Am J Ophthalmol","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.ajo.2003.09.055","article-title":"Optic radiation involvement in optic pathway gliomas in neurofibromatosis","volume":"137","author":"Liu","year":"2004"},{"key":"b15-peds1270","series-title":"Arch Ophthalmol","first-page":"209","article-title":"Primary gliomas of the chiasm and optic nerves in their intra-cranial portion","volume":"52","author":"Martin","year":"1923"},{"key":"b16-peds1270","series-title":"Curr Opin Neurol","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1097\/WCO.0b013e32832d954b","article-title":"White matter atlases based on diffusion tensor imaging","volume":"22","author":"Mori","year":"2009"},{"issue":"1 Suppl","key":"b17-peds1270","series-title":"Neurosurgery","first-page":"178","article-title":"Preoperative and intraoperative diffusion tensor imaging-based fiber tracking in glioma surgery","volume":"61","author":"Nimsky","year":"2007"},{"key":"b18-peds1270","series-title":"Pediatr Neurosurg","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1159\/000028948","article-title":"Chemotherapy: low-grade gliomas of the hypothalamus and thalamus","volume":"32","author":"Packer","year":"2000"},{"key":"b19-peds1270","series-title":"Cancer","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1002\/1097-0142(19900101)65:1<45::AID-CNCR2820650111>3.0.CO;2-Z","article-title":"Definitive radiation therapy in the management of symptomatic patients with optic glioma. Survival and long-term effects","volume":"65","author":"Pierce","year":"1990"},{"key":"b20-peds1270","series-title":"Magn Reson Med","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1002\/mrm.21176","article-title":"Clinical multishot DW-EPI through parallel imaging with considerations of susceptibility, motion, and noise","volume":"57","author":"Skare","year":"2007"},{"key":"b21-peds1270","series-title":"Arch Ophthalmol","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1001\/archopht.1980.01020030501014","article-title":"The architecture of optic nerve gliomas with and without neurofibromatosis","volume":"98","author":"Stern","year":"1980"},{"key":"b22-peds1270","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"583","DOI":"10.3171\/jns.1995.83.4.0583","article-title":"Long-term outcome of hypothalamic\/chiasmatic astrocytomas in children treated with conservative surgery","volume":"83","author":"Sutton","year":"1995"},{"key":"b23-peds1270","series-title":"AJNR Am J Neuroradiol","doi-asserted-by":"publisher","first-page":"816","DOI":"10.3174\/ajnr.A0921","article-title":"Quantitative differentiation between healthy and disordered brain matter in patients with neurofibromatosis type I using diffusion tensor imaging","volume":"29","author":"van Engelen","year":"2008"},{"key":"b24-peds1270","series-title":"Arch Ophthalmol","first-page":"120","article-title":"Primary intraneural tumors (gliomas) of the optic nerve","volume":"51","author":"Verhoeff","year":"1922"},{"key":"b25-peds1270","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"661","DOI":"10.3171\/jns.1990.73.5.0661","article-title":"Surgical management of exophytic chiasmatic-hypothalamic tumors of childhood","volume":"73","author":"Wisoff","year":"1990"},{"key":"b26-peds1270","series-title":"AJNR Am J Neuroradiol","first-page":"92","article-title":"Diffusion tensor fiber tractography of the optic radiation: analysis with 6-, 12-, 40-, and 81-directional motion-probing gradients, a preliminary study","volume":"28","author":"Yamamoto","year":"2007"},{"key":"b27-peds1270","series-title":"AJNR Am J Neuroradiol","first-page":"773","article-title":"Contribution of diffusion tensor MR imaging in detecting cerebral microstructural changes in adults with neurofibromatosis type 1","volume":"28","author":"Zamboni","year":"2007"}],"container-title":["Journal of Neurosurgery: Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/10\/4\/article-p273.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/10\/4\/article-p273.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/10\/4\/article-p273.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T14:32:12Z","timestamp":1681569132000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/10\/4\/article-p273.xml"}},"subtitle":["Clinical article"],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":27,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.3171\/2012.7.peds1270","relation":{},"ISSN":["1933-0707","1933-0715"],"issn-type":[{"value":"1933-0707","type":"print"},{"value":"1933-0715","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}