{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T07:11:01Z","timestamp":1792134661099,"version":"4.4.0"},"reference-count":24,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:sec>\n                    <jats:title>Object<\/jats:title>\n                    <jats:p>The goals of this retrospective cohort study were as follows: 1) to describe the long-term prevalence and timing of hearing deterioration following low-dose (12- to 13-Gy marginal dose) stereotactic radiosurgery (SRS) for vestibular schwannoma (VS); and 2) to identify clinical variables associated with long-term preservation of useful hearing following treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with serviceable hearing who underwent SRS for VS between 1997 and 2002 were studied. Data including radiosurgery treatment plans, tumor characteristics, pre- and posttreatment pure tone average, speech discrimination scores, and American Academy of Otolaryngology\u2013Head and Neck Surgery hearing class were collected. Time to nonserviceable hearing was estimated using the Kaplan-Meier method. Univariate and multivariate associations with time to nonserviceable hearing were evaluated using Cox proportional hazards regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Forty-four patients met the study criteria and were included. The median duration of audiometric follow-up was 9.3 years. Thirty-six patients developed nonserviceable hearing at a mean of 4.2 years following SRS. The Kaplan-Meier estimated rates of serviceable hearing at 1, 3, 5, 7, and 10 years following SRS were 80%, 55%, 48%, 38%, and 23%, respectively. Multivariate analysis revealed that pretreatment ipsilateral pure tone average (p &lt; 0.001) and tumor size (p = 0.009) were statistically significantly associated with time to nonserviceable hearing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Durable hearing preservation a decade after low-dose SRS for VS occurs in less than one-fourth of patients. Variables including preoperative hearing capacity and tumor size may be used to predict hearing outcomes following treatment. These findings may assist in pretreatment risk disclosure. Furthermore, these data demonstrate the importance of long-term follow-up when reporting audiometric outcomes following SRS for VS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2012.9.jns12919","type":"journal-article","created":{"date-parts":[[2012,10,26]],"date-time":"2012-10-26T10:09:22Z","timestamp":1351246162000},"page":"579-587","source":"Crossref","is-referenced-by-count":193,"title":["Long-term hearing outcomes following stereotactic radiosurgery for vestibular schwannoma: patterns of hearing loss and variables influencing audiometric decline"],"prefix":"10.3171","volume":"118","author":[{"given":"Matthew L.","family":"Carlson","sequence":"first","affiliation":[{"name":"Departments of Otolaryngology-Head and Neck Surgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey T.","family":"Jacob","sequence":"additional","affiliation":[{"name":"Neurologic Surgery, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce E.","family":"Pollock","sequence":"additional","affiliation":[{"name":"Neurologic Surgery, and"},{"name":"Radiation Oncology, Mayo Clinic School of Medicine, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian A.","family":"Neff","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology-Head and Neck Surgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole M.","family":"Tombers","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology-Head and Neck Surgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin L. W.","family":"Driscoll","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology-Head and Neck Surgery,"},{"name":"Neurologic Surgery, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Link","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology-Head and Neck Surgery,"},{"name":"Neurologic Surgery, and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-jns12919","series-title":"Otol Neurotol","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1097\/MAO.0b013e3181d8d3ad","article-title":"Radiation therapy for the treatment of vestibular schwannoma: a critical evaluation of the state of the literature","volume":"31","author":"Bassim","year":"2010"},{"key":"b2-jns12919","series-title":"Otol Neurotol","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1097\/00129492-200307000-00023","article-title":"Acoustic neuroma surgery: the results of long-term hearing preservation","volume":"24","author":"Chee","year":"2003"},{"key":"b3-jns12919","series-title":"Int J Radiat Oncol Biol Phys","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1016\/j.ijrobp.2007.01.001","article-title":"Long-term follow-up of acoustic schwannoma radiosurgery with marginal tumor doses of 12 to 13 Gy","volume":"68","author":"Chopra","year":"2007"},{"key":"b4-jns12919","series-title":"Otolaryngol Head Neck Surg","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/S0194-5998(95)70101-X","article-title":"Committee on Hearing and Equilibrium guidelines for the evaluation of hearing preservation in acoustic neuroma (vestibular schwannoma)","volume":"113","author":"Committee on Hearing and Equilibrium","year":"1995"},{"key":"b5-jns12919","series-title":"J Laryngol Otol","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1258\/0022215054273089","article-title":"Conservative management of sporadic unilateral acoustic neuromas","volume":"119","author":"Flint","year":"2005"},{"key":"b6-jns12919","series-title":"Otolaryngol Head Neck Surg","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1016\/j.otohns.2003.08.002","article-title":"Long-term hearing preservation after middle fossa removal of vestibular schwannoma","volume":"129","author":"Friedman","year":"2003"},{"key":"b7-jns12919","series-title":"Otol Neurotol","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1097\/MAO.0b013e3181e8fc3f","article-title":"Fundal fluid as a predictor of hearing preservation in the middle cranial fossa approach for vestibular schwannoma","volume":"31","author":"Goddard","year":"2010"},{"key":"b8-jns12919","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.3171\/2011.7.JNS11749","article-title":"Factors associated with hearing preservation after Gamma Knife surgery for vestibular schwannomas in patients who retain serviceable hearing. 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