{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:47:45Z","timestamp":1784767665506,"version":"3.55.0"},"reference-count":50,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:sec>\n<jats:title>Object<\/jats:title>\n<jats:p>Decompressive craniectomy mandates subsequent cranioplasty. Complications of cranioplasty may be independent of the initial craniectomy, or they may be contingent upon the craniectomy. Authors of this study aimed to identify surgery- and patient-specific risk factors related to the development of surgical site infection and other complications following cranioplasty.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>A consecutive cohort of patients of all ages and both sexes who had undergone cranioplasty following craniectomy for stroke or trauma at a single institution in the period from May 2004 to May 2012 was retrospectively established. Patients who had undergone craniectomy for infectious lesions or neoplasia were excluded. A logistic regression analysis was performed to model and predict determinants related to infection following cranioplasty.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Two hundred thirty-nine patients met the study criteria. The overall rate of complication following cranioplasty was 23.85% (57 patients). Complications included, predominantly, surgical site infection, hydrocephalus, and new-onset seizures. Logistic regression analysis identified previous reoperation (OR 3.25, 95% CI 1.30\u20138.11, p = 0.01) and therapeutic indication for stroke (OR 2.45, 95% CI 1.11\u20135.39, p = 0.03) as significantly associated with the development of cranioplasty infection. Patient age, location of cranioplasty, presence of an intracranial device, bone flap preservation method, cranioplasty material, booking method, and time interval &gt; 90 days between initial craniectomy and cranioplasty were not predictive of the development of cranioplasty infection.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Cranioplasty complications are common. Cranioplasty infection rates are predicted by reoperation following craniectomy and therapeutic indication (stroke). These variables may be associated with patient-centered risk factors that increase cranioplasty infection risk.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2013.1.jns121626","type":"journal-article","created":{"date-parts":[[2013,2,8]],"date-time":"2013-02-08T14:12:23Z","timestamp":1360332743000},"page":"757-762","source":"Crossref","is-referenced-by-count":115,"title":["Predictors of cranioplasty complications in stroke and trauma patients"],"prefix":"10.3171","volume":"118","author":[{"given":"Brian P.","family":"Walcott","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Churl-Su","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameer A.","family":"Sheth","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corey R.","family":"Fehnel","sequence":"additional","affiliation":[{"name":"Department of Neurology, Brown University Alpert Medical School and Rhode Island Hospital; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Koffie","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wael F.","family":"Asaad","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Brown Institute for Brain Science, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian V.","family":"Nahed","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Valery","family":"Coumans","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-jns121626","series-title":"Crit Care Med","doi-asserted-by":"publisher","first-page":"2535","DOI":"10.1097\/01.CCM.0000089927.67396.F3","article-title":"Decompressive craniectomy for severe traumatic brain injury: evaluation of the effects at one year","volume":"31","author":"Alban\u00e8se","year":"2003"},{"key":"b2-jns121626","series-title":"J Trauma","first-page":"270","article-title":"Cranioplasty after postinjury decompressive craniectomy: is timing of the essence?","volume":"69","author":"Beauchamp","year":"2010"},{"key":"b3-jns121626","series-title":"Neurosurgery","first-page":"S16","article-title":"Surgical management of acute subdural hematomas","volume":"58","author":"Bullock","year":"2006"},{"key":"b4-jns121626","series-title":"Lancet","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/S0140-6736(05)17783-6","article-title":"Isolation of patients in single rooms or cohorts to reduce spread of MRSA in intensive-care units: prospective two-centre study","volume":"365","author":"Cepeda","year":"2005"},{"key":"b5-jns121626","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.3171\/2009.6.JNS09133","article-title":"Outcomes of cranial repair after craniectomy. 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