{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:38:44Z","timestamp":1791290324883,"version":"4.3.0"},"reference-count":30,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2013,6]]},"abstract":"\n Object<\/jats:title>\n Laser interstitial thermal therapy has been used as an ablative treatment for glioma; however, its development was limited due to technical issues. The NeuroBlate System incorporates several technological advances to overcome these drawbacks. The authors report a Phase I, thermal dose\u2013escalation trial assessing the safety and efficacy of NeuroBlate in recurrent glioblastoma multiforme (rGBM).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Adults with suspected supratentorial rGBM of 15- to 40-mm dimension and a Karnofsky Performance Status score of \u2265 60 were eligible. After confirmatory biopsy, treatment was delivered using a rigid, gas-cooled, side-firing laser probe. Treatment was monitored using real-time MRI thermometry, and proprietary software providing predictive thermal damage feedback was used by the surgeon, along with control of probe rotation and depth, to tailor tissue coagulation. An external data safety monitoring board determined if toxicity at lower levels justified dose escalation.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Ten patients were treated at the Case Comprehensive Cancer Center (Cleveland Clinic and University Hospitals\u2013Case Medical Center). Their average age was 55 years (range 34\u201369 years) and the median preoperative Karnofsky Performance Status score was 80 (range 70\u201390). The mean tumor volume was 6.8 \u00b1 5 cm\n 3<\/jats:sup>\n (range 2.6\u201319 cm\n 3<\/jats:sup>\n ), the percentage of tumor treated was 78% \u00b1 12% (range 57%\u201390%), and the conformality index was 1.21 \u00b1 0.33 (range 1.00\u20132.04). Treatment-related necrosis was evident on MRI studies at 24 and 48 hours. The median survival was 316 days (range 62\u2013767 days). Three patients improved neurologically, 6 remained stable, and 1 worsened. Steroid-responsive treatment-related edema occurred in all patients but one. Three had Grade 3 adverse events at the highest dose.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n NeuroBlate represents new technology for delivering laser interstitial thermal therapy, allowing controlled thermal ablation of deep hemispheric rGBM. Clinical trial registration no.: NCT00747253 (\n ClinicalTrials.gov<\/jats:ext-link>\n ).\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3171\/2013.1.jns1291","type":"journal-article","created":{"date-parts":[[2013,4,5]],"date-time":"2013-04-05T12:13:04Z","timestamp":1365163984000},"page":"1202-1219","source":"Crossref","is-referenced-by-count":207,"title":["Results of the NeuroBlate System first-in-humans Phase I clinical trial for recurrent glioblastoma"],"prefix":"10.3171","volume":"118","author":[{"given":"Andrew E.","family":"Sloan","sequence":"first","affiliation":[{"name":"Brain Tumor & Neuro-Oncology Center and Department of Neurosurgery, and"},{"name":"Case Comprehensive Cancer Center, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manmeet S.","family":"Ahluwalia","sequence":"additional","affiliation":[{"name":"Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Neurological Institute, Cleveland Clinic;"},{"name":"Department of Solid Tumor Oncology, 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