{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:14:38Z","timestamp":1792509278055,"version":"4.5.0"},"reference-count":16,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PED"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:p>Dysembryoplastic neuroepithelial tumors (DNETs) have conventionally been regarded as benign and stable tumors and considered curable with surgery without adjunctive therapy. Recently, recurrent DNETs with or without malignant transformation have been described. The authors report 2 unusual cases of DNET: 1) an enlarging lesion that developed an enhancing component over the natural course of 4 years, and 2) a recurrent DNET that developed an enhancing component 10\u201311 years after gross-total resection. The patient in the first case was treated with subtotal resection and adjuvant radiochemotherapy; histological examination of the tumor led to the diagnosis of DNET, WHO Grade I, for the nonenhancing component and anaplastic oligodendroglioma, WHO Grade III, for the enhancing component. The patient in the second case was treated with repeat gross-total resection; the original tumor had been histologically diagnosed as DNET, and the nonenhancing and enhancing components of the recurrent tumor were diagnosed as simple and complex forms of DNET, respectively. These and previous reports suggest an aggressive subtype of DNETs. If follow-up MRI reveals progressive behavior, resection should be performed without delay. Additional radiochemotherapy is needed if the histological diagnosis demonstrates malignant transformation.<\/jats:p>","DOI":"10.3171\/2013.1.peds11449","type":"journal-article","created":{"date-parts":[[2013,2,22]],"date-time":"2013-02-22T15:30:17Z","timestamp":1361547017000},"page":"518-525","source":"Crossref","is-referenced-by-count":25,"title":["Dynamic changes in magnetic resonance imaging appearance of dysembryoplastic neuroepithelial tumor with or without malignant transformation"],"prefix":"10.3171","volume":"11","author":[{"given":"Yui","family":"Mano","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Tohoku University Graduate School of Medicine; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Kumabe","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tohoku University Graduate School of Medicine; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiyo","family":"Shibahara","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tohoku University Graduate School of Medicine; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuta","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tohoku University Graduate School of Medicine; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihiko","family":"Sonoda","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tohoku University Graduate School of Medicine; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tohoku University Hospital, Sendai, Miyagi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teiji","family":"Tominaga","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tohoku University Graduate School of Medicine; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-peds11449","series-title":"Neuroradiology","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1007\/s00234-009-0511-1","article-title":"Simple and complex dysembryoplastic neuroepithelial tumors (DNT) variants: clinical profile, MRI, and histopathology","volume":"51","author":"Campos","year":"2009"},{"key":"b2-peds11449","series-title":"Acta Neuropathol","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/s00401-010-0770-2","article-title":"Mutation-specific IDH1 antibody differentiates oligodendrogliomas and oligoastrocytomas from other brain tumors with oligodendroglioma-like morphology","volume":"121","author":"Capper","year":"2011"},{"key":"b3-peds11449","series-title":"WHO Classification of Tumours of the Central Nervous System","first-page":"99","article-title":"Dysembryoplastic neuroepithelial tumour","author":"Daumas-Duport","year":"2007"},{"key":"b4-peds11449","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1227\/00006123-198811000-00002","article-title":"Dysembryoplastic neuroepithelial tumor: a surgically curable tumor of young patients with intractable partial seizures. 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