{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T14:41:42Z","timestamp":1681569702274},"reference-count":19,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PED"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:p>The authors present the rare case of complete image-defined resolution of a hypothalamic hamartoma (HH) following Gamma Knife surgery (GKS). A 9-month-old girl presented with an episode of generalized tonic-clonic seizures. Magnetic resonance imaging revealed a left-sided HH, which remained radiologically stable. By 3 years of age the patient had a development delay of 12 months, and experienced 8 gelastic seizures per day while on 2 antiepileptic medications. Thirty-one months after presentation, the patient underwent elective GKS to treat the HH. She has since been seizure free for 22 months, while receiving 3 antiepileptic medications. Twelve months after radiosurgery, MRI revealed complete radiological resolution of the lesion. The authors discuss alternative management options for HH, including microsurgical resection, endoscopic disconnection, stereotactic radiofrequency thermocoagulation, and interstitial radiosurgery. Gamma Knife surgery is a minimally invasive procedure associated with a lower morbidity rate than that of published surgical results. The present case demonstrates the potential for complete image-defined resolution of an HH post-GKS, without long-term neurological sequelae, emphasizing the safety and efficacy of this therapeutic option for the control of epileptic seizures produced by small-volume, surgically inaccessible HHs.<\/jats:p>","DOI":"10.3171\/2013.1.peds12290","type":"journal-article","created":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T18:35:53Z","timestamp":1359743753000},"page":"464-468","source":"Crossref","is-referenced-by-count":1,"title":["Image-defined resolution following radiosurgery for hypothalamic hamartoma"],"prefix":"10.3171","volume":"11","author":[{"given":"Lucy","family":"O'Connor","sequence":"first","affiliation":[{"name":"Manchester Medical School, University of Manchester;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Curl-Roper","sequence":"additional","affiliation":[{"name":"Manchester Medical School, University of Manchester;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Reeves","sequence":"additional","affiliation":[{"name":"Manchester Medical School, University of Manchester;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andras A.","family":"Kemeny","sequence":"additional","affiliation":[{"name":"National Centre for Stereotactic Radiosurgery, Royal Hallamshire Hospital, Sheffield, England"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivek A.","family":"Josan","sequence":"additional","affiliation":[{"name":"Royal Manchester Children's Hospital, Manchester; and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"3","key":"b1-peds12290","series-title":"Neurosurg Focus","doi-asserted-by":"publisher","first-page":"E8","DOI":"10.3171\/FOC\/2008\/25\/9\/E8","article-title":"Surgical management of hypothalamic hamartomas in patients with gelastic epilepsy","volume":"25","author":"Addas","year":"2008"},{"key":"b2-peds12290","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"645","DOI":"10.3171\/jns.1998.89.4.0645","article-title":"Subsidence of seizure induced by stereotactic radiation in a patient with hypothalamic hamartoma. 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