{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T09:58:33Z","timestamp":1755597513261},"reference-count":31,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec>\n<jats:title>Object<\/jats:title>\n<jats:p>Evidence suggests that hormones play a role in modifying both uterine myoma (UM) and meningioma. A number of studies have observed the positive association between these diseases. The aim of the current population-based study was to determine if women with UM are at a higher risk for meningioma.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>The authors used data from the National Health Insurance system of Taiwan for the study. The UM cohort contained 281,244 women. Each woman was randomly frequency-matched with 4 women without UM, based on age, index year of diagnosis, occupation, urbanization (urbanization level was categorized by the population density of the residential area into 4 levels, with Level 1 as the most urbanized and Level 4 as the least urbanized), and comorbidity, to form the control cohort. Cox's proportional hazard regression analysis was conducted to estimate the influence of UM on the meningioma risk.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Among women with UM, the risk of developing meningioma was significantly higher (45%) than among women without UM (95% CI 1.23\u20131.70). The same phenomenon was observed among most age groups, but a significant difference was only seen in the middle-age range. For women with UM, further analysis did not show a significant change after myomectomy. The cumulative incidence of meningioma between groups with and without UM differed over time.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The nationwide population-based cohort study found that Taiwanese women with UM are at higher risk for developing meningioma.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2013.10.jns131357","type":"journal-article","created":{"date-parts":[[2013,12,6]],"date-time":"2013-12-06T15:16:13Z","timestamp":1386342973000},"page":"655-661","source":"Crossref","is-referenced-by-count":9,"title":["Higher risk for meningioma in women with uterine myoma: a nationwide population-based retrospective cohort study"],"prefix":"10.3171","volume":"120","author":[{"given":"Yu-Shu","family":"Yen","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, School of Medicine, National Yang-Ming University, Taipei;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Min","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Li","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Public Health, College of Public Health, China Medical University;"},{"name":"Management Office for Health Data, China Medical University Hospital;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih-Ni","family":"Chang","sequence":"additional","affiliation":[{"name":"Institute of Public Health, College of Public Health, China Medical University;"},{"name":"Management Office for Health Data, China Medical University Hospital;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fung-Chang","family":"Sung","sequence":"additional","affiliation":[{"name":"Institute of Public Health, College of Public Health, China Medical University;"},{"name":"Management Office for Health Data, China Medical University Hospital;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Hung","family":"Kao","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medical Science, School of Medicine, College of Medicine, China Medical University; and"},{"name":"Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-jns131357","series-title":"J Neurol Neurosurg Psychiatry","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1136\/jnnp.21.2.89","article-title":"The relapsing course of certain meningiomas in relation to pregnancy and menstruation","volume":"21","author":"Bickerstaff","year":"1958"},{"key":"b2-jns131357","series-title":"J Neurooncol","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/BF00165649","article-title":"Epidemiology and etiology of intracranial meningiomas: a review","volume":"29","author":"Bondy","year":"1996"},{"key":"b3-jns131357","series-title":"CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States, 2004\u20132006","author":"Central Brain Tumor Registry of the United States"},{"key":"b4-jns131357","series-title":"Thyroid","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1089\/thy.2012.0568","article-title":"Cancer risk in patients with Graves' disease: a nationwide cohort study","volume":"23","author":"Chen","year":"2013"},{"key":"b5-jns131357","series-title":"Taiwan J Obstet Gynecol","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/S1028-4559(08)60001-7","article-title":"Unusual clinical presentation of uterine myomas","volume":"46","author":"Cheng","year":"2007"},{"key":"b6-jns131357","series-title":"Six Countries, Six Reform Models: The Health Reform Experience of Israel, the Netherlands, New Zealand, Singapore, Switzerland and Taiwan","first-page":"171","article-title":"Taiwan's national health insurance system: high value for the dollar","author":"Cheng","year":"2009"},{"key":"b7-jns131357","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.3171\/2011.6.JNS11129","article-title":"Family and personal medical history and risk of meningioma. 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