{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:41:58Z","timestamp":1790196118919,"version":"4.1.0"},"reference-count":160,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FOC"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:p>Hypothalamic hamartomas are uncommon developmental heterotopic masses composed of an intermixed array of neurons, glia, and myelinated fibers closely associated with the mammillary bodies. Gelastic seizures, the hallmark feature of hypothalamic hamartomas, commonly present in early childhood. However, patients usually also display a disabling clinical syndrome, which may include various other types of refractory seizures with secondary generalization together with progressive cognitive, behavioral, and psychiatric dysfunction. The hamartoma itself has been unequivocally shown to be intrinsically epileptogenic. Over the past 2 decades there has been considerable effort to develop neurosurgical techniques to treat the epileptic syndrome effectively as well as to improve the neurocognitive and behavioral outcome.<\/jats:p>","DOI":"10.3171\/2013.3.focus1356","type":"journal-article","created":{"date-parts":[[2013,5,31]],"date-time":"2013-05-31T10:11:43Z","timestamp":1369995103000},"page":"E7","source":"Crossref","is-referenced-by-count":60,"title":["Hypothalamic hamartomas. Part 2. 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