{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T12:13:41Z","timestamp":1789820021076,"version":"4.0.1"},"reference-count":27,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:sec>\n<jats:title>Object<\/jats:title>\n<jats:p>This study was performed to investigate the risk factors related to the growth of small, asymptomatic, unruptured aneurysms in patients with no history of subarachnoid hemorrhage (SAH).<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Between January 2005 and December 2010, a total of 508 patients in whom unruptured intracranial aneurysms were diagnosed at the University of California, Los Angeles medical center did not receive treatment to prevent rupture. Of these, 235 patients with no history of SAH who had asymptomatic, small, unruptured aneurysms (&lt; 7 mm) were monitored with 3D CT angiography images. Follow-up images of the lesions were used to measure aneurysm size changes. Patient medical history, family history of SAH, aneurysm size, and location were studied to find the risk factors associated with small aneurysm growth.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>A total of 319 small aneurysms were included, with follow-up durations of 29.2 \u00b1 20.6 months. Forty-two aneurysms increased in size during the follow-up; 5 aneurysms grew to become \u2265 7 mm within 38.2 \u00b1 18.3 months. A trend of higher growth rates was found in single aneurysms than in multiple aneurysms (p = 0.07). A history of stroke was the only factor associated with single aneurysm growth (p = 0.03). The number of aneurysms (p = 0.011), number of aneurysms located within the posterior circulation (p = 0.030), and patient history of transient ischemic attack (p = 0.044) were related to multiple aneurysm growth.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Multiple small aneurysms are more likely to grow, and multiple aneurysms located in the posterior circulation may require additional attention. Although single aneurysms have a lower risk of growth, a trend of higher growth rates in single aneurysms was found.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2013.3.jns121469","type":"journal-article","created":{"date-parts":[[2013,4,26]],"date-time":"2013-04-26T14:06:22Z","timestamp":1366985182000},"page":"190-197","source":"Crossref","is-referenced-by-count":70,"title":["Enlargement of small, asymptomatic, unruptured intracranial aneurysms in patients with no history of subarachnoid hemorrhage: the different factors related to the growth of single and multiple aneurysms"],"prefix":"10.3171","volume":"119","author":[{"given":"Aichi","family":"Chien","sequence":"first","affiliation":[{"name":"Department of Radiology, David Geffen School of Medicine at UCLA; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Radiology, David Geffen School of Medicine at UCLA; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Sayre","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, School of Public Health, UCLA, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Salamon","sequence":"additional","affiliation":[{"name":"Department of Radiology, David Geffen School of Medicine at UCLA; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Villablanca","sequence":"additional","affiliation":[{"name":"Department of Radiology, David Geffen School of Medicine at UCLA; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Vi\u00f1uela","sequence":"additional","affiliation":[{"name":"Department of Radiology, David Geffen School of Medicine at UCLA; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-jns121469","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"617","DOI":"10.3171\/jns.1976.45.6.0617","article-title":"Angiographic study of the growth of intracranial aneurysms","volume":"45","author":"Allcock","year":"1976"},{"key":"b2-jns121469","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1161\/STROKEAHA.108.519165","article-title":"Intracranial aneurysm enlargement on serial magnetic resonance angiography: frequency and risk factors","volume":"40","author":"Burns","year":"2009"},{"key":"b3-jns121469","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1227\/NEU.0b013e31820edbd3","article-title":"Relationship of growth to aneurysm rupture in asymptomatic aneurysms \u2264 7 mm: a systematic analysis of the literature","volume":"68","author":"Chmayssani","year":"2011"},{"key":"b4-jns121469","series-title":"J Magn Reson Imaging","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1002\/jmri.20944","article-title":"Estimation of fusiform intracranial aneurysm growth by serial magnetic resonance imaging","volume":"26","author":"Dispensa","year":"2007"},{"key":"b5-jns121469","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1161\/01.STR.0000152269.73262.68","article-title":"Patients with small, asymptomatic, unruptured intracranial aneurysms and no history of subarachnoid hemorrhage should be treated conservatively","volume":"36","author":"Donnan","year":"2005"},{"key":"b6-jns121469","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1161\/STROKEAHA.110.591594","article-title":"De novo aneurysm formation and growth of untreated aneurysms: a 5-year MRA follow-up in a large cohort of patients with coiled aneurysms and review of the literature","volume":"42","author":"Ferns","year":"2011"},{"key":"b7-jns121469","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1161\/01.STR.24.11.1649","article-title":"Impact of early surgery on outcome after aneurysmal subarachnoid hemorrhage. 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