{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T21:01:27Z","timestamp":1771707687448,"version":"3.50.1"},"reference-count":12,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PED"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:p>Neurocutaneous melanosis (NCM) is a rare, congenital neuroectodermal dysplasia generally resulting in early death from neurological decline due to leptomeningeal involvement. Nonmeningeal CNS epileptogenic lesions presenting in later childhood in the absence of leptomeningeal disease are rare. This report summarizes a rare presentation and curative epilepsy surgery.<\/jats:p>\n<jats:p>The authors discuss the case of a 14-year-old girl with NCM who originally presented with intractable partial-onset seizures. The MRI, PET, and SPECT studies subsequently revealed a focal epileptogenic source in the right temporal lobe. Results of video-electroencephalography monitoring concurred with the imaging findings, and a right temporal lobectomy was performed including the medial structures. Following surgery, histopathological features of the lesion included multiple scattered mononuclear cells with brown pigmentation in the amygdala specimen. The patient remains seizure free 2 years postresection, and no longer needs medication for seizure management.<\/jats:p>\n<jats:p>This patient presented with an atypical CNS manifestation of NCM that is curable by epilepsy surgery. Her intractable epilepsy developed secondary to amygdalar neuromelanosis, which had no associated leptomeningeal melanosis, an uncommon occurrence. As evidenced by the lack of seizure activity following resection, the patient's quality of life greatly improved after neurological surgery.<\/jats:p>","DOI":"10.3171\/2013.3.peds12502","type":"journal-article","created":{"date-parts":[[2013,5,3]],"date-time":"2013-05-03T14:23:52Z","timestamp":1367591032000},"page":"21-24","source":"Crossref","is-referenced-by-count":8,"title":["Amygdalar neuromelanosis intractable epilepsy without leptomeningeal involvement"],"prefix":"10.3171","volume":"12","author":[{"given":"Douglas R.","family":"Taylor","sequence":"first","affiliation":[{"name":"University of Tennessee Health Science Center,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott D.","family":"Wait","sequence":"additional","affiliation":[{"name":"University of Tennessee Health Science Center,"},{"name":"LeBonheur Comprehensive Epilepsy Program & Neuroscience Institute, and"},{"name":"St. Jude Children's Research Hospital, Memphis, Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James W.","family":"Wheless","sequence":"additional","affiliation":[{"name":"University of Tennessee Health Science Center,"},{"name":"LeBonheur Comprehensive Epilepsy Program & Neuroscience Institute, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederick A.","family":"Boop","sequence":"additional","affiliation":[{"name":"University of Tennessee Health Science Center,"},{"name":"LeBonheur Comprehensive Epilepsy Program & Neuroscience Institute, and"},{"name":"St. Jude Children's Research Hospital, Memphis, Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-peds12502","series-title":"Epileptic Disord","first-page":"57","article-title":"Neurocutaneous melanosis and epilepsy surgery","volume":"7","author":"Andermann","year":"2005"},{"key":"b2-peds12502","series-title":"Pediatr Pathol","doi-asserted-by":"publisher","first-page":"253","DOI":"10.3109\/15513818809042969","article-title":"The melanocytic differentiation pathway in congenital melanocytic nevi: theoretical considerations","volume":"8","author":"Cramer","year":"1988"},{"key":"b3-peds12502","series-title":"Epileptic Disord","first-page":"145","article-title":"An unusual case of neurocutaneous melanosis","volume":"6","author":"de Andrade","year":"2004"},{"key":"b4-peds12502","series-title":"J Am Acad Dermatol","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/S0190-9622(96)90674-X","article-title":"Neurocutaneous melanosis: clinical features of large congenital melanocytic nevi in patients with manifest central nervous system melanosis","volume":"35","author":"DeDavid","year":"1996"},{"key":"b5-peds12502","series-title":"AJNR Am J Neuroradiol","first-page":"603","article-title":"MR of parenchymal neurocutaneous melanosis","volume":"16","author":"Demirci","year":"1995"},{"key":"b6-peds12502","series-title":"Plast Reconstr Surg","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1097\/00006534-199501000-00022","article-title":"Primary temporal melanoma without diffuse leptomeningeal involvement: a variant of neurocutaneous melanosis","volume":"95","author":"Eaves","year":"1995"},{"key":"b7-peds12502","series-title":"Plast Reconstr Surg","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1097\/00006534-200104010-00005","article-title":"Giant congenital melanocytic nevi: the significance of neurocutaneous melanosis in neurologically asymptomatic children","volume":"107","author":"Foster","year":"2001"},{"key":"b8-peds12502","series-title":"Arch Dis Child","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1136\/adc.39.207.508","article-title":"Neurocutaneous melanosis","volume":"39","author":"Fox","year":"1964"},{"key":"b9-peds12502","series-title":"J Neurosurg Pediatr","doi-asserted-by":"publisher","first-page":"82","DOI":"10.3171\/2010.3.PEDS1025","article-title":"Neurocutaneous melanosis: surgical pathological features of an apparently hamartomatous lesion in the amygdala. Case report","volume":"6","author":"Fu","year":"2010"},{"key":"b10-peds12502","series-title":"J Am Acad Dermatol","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/0190-9622(91)70115-I","article-title":"Neurocutaneous melanosis: definition and review of the literature","volume":"24","author":"Kadonaga","year":"1991"},{"key":"b11-peds12502","series-title":"AJNR Am J Neuroradiol","first-page":"699","article-title":"Neurocutaneous melanosis and temporal lobe tumor in a child: MR study","volume":"12","author":"Sebag","year":"1991"},{"key":"b12-peds12502","series-title":"J Clin Neurol","doi-asserted-by":"publisher","first-page":"134","DOI":"10.3988\/jcn.2008.4.3.134","article-title":"Neurocutaneous melanosis presenting as chronic partial epilepsy","volume":"4","author":"Ye","year":"2008"}],"container-title":["Journal of Neurosurgery: Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/12\/1\/article-p21.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/12\/1\/article-p21.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/12\/1\/article-p21.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T12:44:06Z","timestamp":1681562646000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/12\/1\/article-p21.xml"}},"subtitle":["Case report"],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":12,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3171\/2013.3.peds12502","relation":{},"ISSN":["1933-0707","1933-0715"],"issn-type":[{"value":"1933-0707","type":"print"},{"value":"1933-0715","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7]]}}}