{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T15:57:27Z","timestamp":1711641447639},"reference-count":20,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PED"],"published-print":{"date-parts":[[2013,7]]},"abstract":"\nObject<\/jats:title>\nIn patients with tuberous sclerosis complex (TSC), the tuber-to-brain proportion (TBP) is a marker of seizure severity and cognitive function. However, few studies have quantified the TBP. Furthermore, authors of these studies have measured the TBP at only a single time point, despite the fact that tuber cells were found to express proliferation markers, suggesting that they may be dynamic lesions. Authors of the present study used a semi-automated tuber segmentation program to determine whether the TBP changes over time.<\/jats:p><\/jats:sec>\n\nMethods<\/jats:title>\nAxial FLAIR MR images were retrospectively identified for patients with TSC who had undergone imaging at the authors' institution between February 1998 and June 2009. Using FireVoxel software, the TBP was measured for each patient at a minimum interval of 2 years.<\/jats:p><\/jats:sec>\n\nResults<\/jats:title>\nTwelve patients meeting the study inclusion criteria were identified. The mean TBP was 1.88% (range 0.38%\u20133.70%). Eight patients demonstrated minimal changes and 3 patients demonstrated small increases in TBP. The remaining patient exhibited a decrease of 1.00%, which correlated with a visible decrease in the size of 2 cerebellar lesions.<\/jats:p><\/jats:sec>\n\nConclusions<\/jats:title>\nSemi-automated brain segmentation is a valuable tool in the longitudinal study of tubers. A subset of patients with TSC, particularly those with cerebellar lesions, may exhibit changes in the TBP over time.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2013.4.peds12468","type":"journal-article","created":{"date-parts":[[2013,5,10]],"date-time":"2013-05-10T14:09:22Z","timestamp":1368194962000},"page":"71-76","source":"Crossref","is-referenced-by-count":4,"title":["Longitudinal quantitative analysis of the tuber-to-brain proportion in patients with tuberous sclerosis"],"prefix":"10.3171","volume":"12","author":[{"given":"David S.","family":"Hersh","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, University of Maryland Medical Center, Baltimore, Maryland;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Chun","sequence":"additional","affiliation":[{"name":"Departments of Radiology and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard L.","family":"Weiner","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Division of Pediatric Neurosurgery;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Pulitzer","sequence":"additional","affiliation":[{"name":"Department of Radiology, SUNY Downstate Medical Center, Brooklyn, New York; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry","family":"Rusinek","sequence":"additional","affiliation":[{"name":"Departments of Radiology and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Roth","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurosurgery, Dana Children's Hospital, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orrin","family":"Devinsky","sequence":"additional","affiliation":[{"name":"Neurology, NYU Langone Medical Center, New York;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah S.","family":"Milla","sequence":"additional","affiliation":[{"name":"Departments of Radiology and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-peds12468","series-title":"J Child Neurol","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1177\/08830738050200101301","article-title":"Prognostic significance of tuber count and location in tuberous sclerosis complex","volume":"20","author":"Doherty","year":"2005"},{"key":"b2-peds12468","series-title":"J Child Neurol","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1177\/088307389701200203","article-title":"Cortical tuber count: a biomarker indicating neurologic severity of tuberous sclerosis complex","volume":"12","author":"Goodman","year":"1997"},{"key":"b3-peds12468","series-title":"Neuroradiology","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1007\/BF00404101","article-title":"Magnetic resonance images of tuberous sclerosis. 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