{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T18:42:14Z","timestamp":1782931334882,"version":"3.54.5"},"reference-count":18,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PED"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:p>Hypothalamic hamartoma (HH) is a rare condition that often manifests as central precocious puberty (CPP). There is a lack of information available concerning the long-term effectiveness of surgery for the treatment of CPP due to HH. Here the authors describe 3 cases of CPP due to HH, with a follow-up ranging from 9 to 11 years after surgery. Three girls experienced breast growth and menses at 5\u201318 months of age and 5\u201336 months of age, respectively. Serum concentrations of luteinizing hormone, follicle-stimulating hormone, and estradiol concentrations ranged from 2.5 to 6.5 mIU\/ml, 4.8\u20135.9 mIU\/ml, and 47.9\u2013133.0 pg\/ml, respectively. Magnetic resonance imaging confirmed that CPP was caused by HH. Lesions were resected using a right pterional approach. After surgery, endocrine hormone concentrations were normalized, breasts shrunk, and menses ceased in each patient. Moreover, all of them subsequently developed normally and experienced age-appropriate onset of puberty. Each patient's height and weight were normal at the most recent follow-up (9\u201311 years after surgery), and none had experienced learning difficulties. Central precocious puberty due to HH can be successfully treated with resection. In the 3 cases presented, this approach was associated with both short- and long-term efficacy.<\/jats:p>","DOI":"10.3171\/2013.4.peds12617","type":"journal-article","created":{"date-parts":[[2013,6,7]],"date-time":"2013-06-07T13:57:58Z","timestamp":1370613478000},"page":"151-154","source":"Crossref","is-referenced-by-count":13,"title":["Surgical treatment of hypothalamic hamartoma causing central precocious puberty: long-term follow-up"],"prefix":"10.3171","volume":"12","author":[{"given":"Chun-de","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-qi","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-yu","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-qi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie-fei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-peds12617","series-title":"Endocr Pract","doi-asserted-by":"publisher","first-page":"237","DOI":"10.4158\/EP09193.CR","article-title":"A rare case of central precocious puberty due to hypothalamic hamartoma diagnosed in utero","volume":"16","author":"Acharya","year":"2010"},{"key":"b2-peds12617","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"77","DOI":"10.3171\/jns.1993.78.1.0077","article-title":"Neurosurgical treatment of hypothalamic hamartomas causing precocious puberty","volume":"78","author":"Albright","year":"1993"},{"key":"b3-peds12617","series-title":"Neurol Med Chir (Tokyo)","doi-asserted-by":"publisher","first-page":"221","DOI":"10.2176\/nmc.45.221","article-title":"Hypothalamic hamartoma","volume":"45","author":"Arita","year":"2005"},{"key":"b4-peds12617","series-title":"AJNR Am J Neuroradiol","first-page":"309","article-title":"Hamartomas of the tuber cinereum: CT, MR, and pathologic findings","volume":"12","author":"Boyko","year":"1991"},{"key":"b5-peds12617","series-title":"N Engl J Med","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1056\/NEJM199101103240205","article-title":"Gonadotropin-releasing hormone and its analogues","volume":"324","author":"Conn","year":"1991"},{"key":"b6-peds12617","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"288","DOI":"10.3171\/jns.1985.62.2.0288","article-title":"Hypothalamic hamartoma successfully treated by operation. Case report","volume":"62","author":"Kyuma","year":"1985"},{"key":"b7-peds12617","series-title":"Pediatric Endocrinology","year":"2007"},{"key":"b8-peds12617","series-title":"Surg Neurol","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/S0090-3019(02)00694-8","article-title":"Microsurgical treatment for hypothalamic hamartoma in children with precocious puberty","volume":"57","author":"Luo","year":"2002"},{"key":"b9-peds12617","series-title":"J Clin Endocrinol Metab","first-page":"118","article-title":"The luteinizing hormone-releasing hormone-secreting hypothalamic hamartoma is a congenital malformation: natural history","volume":"77","author":"Mahachoklertwattana","year":"1993"},{"key":"b10-peds12617","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/s003810000361","article-title":"Hypothalamic hamartoma: the role of surgery in a series of eight patients","volume":"17","author":"Mottolese","year":"2001"},{"key":"b11-peds12617","series-title":"Neurosurg Rev","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/BF00258250","article-title":"Hypothalamic hamartoma: the role of surgery","volume":"16","author":"Nishio","year":"1993"},{"key":"b12-peds12617","series-title":"J Pediatr","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/S0022-3476(86)80767-3","article-title":"The NIH experience with precocious puberty: diagnostic subgroups and response to short-term luteinizing hormone releasing hormone analogue therapy","volume":"108","author":"Pescovitz","year":"1986"},{"key":"b13-peds12617","series-title":"Epileptic Disord","first-page":"281","article-title":"Resective surgery for hypothalamic hamartoma","volume":"5","author":"Polkey","year":"2003"},{"key":"b14-peds12617","series-title":"Surg Neurol","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/0090-3019(94)90179-1","article-title":"Hypothalamic hamartoma causing precocious puberty treated by surgery: case report","volume":"41","author":"Romner","year":"1994"},{"key":"b15-peds12617","series-title":"Semin Pediatr Neurol","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.spen.2007.03.007","article-title":"Hypothalamic hamartoma treatment: surgical resection with the transcallosal approach","volume":"14","author":"Rosenfeld","year":"2007"},{"key":"b16-peds12617","series-title":"Pediatr Neurosurg","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1159\/000082302","article-title":"Hypothalamic hamartoma with precocious puberty","volume":"40","author":"Shenoy","year":"2004"},{"key":"b17-peds12617","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"340","DOI":"10.3171\/jns.1998.88.2.0340","article-title":"Role of surgical resection in the treatment of hypothalamic hamartomas causing precocious puberty. Report of six cases","volume":"88","author":"Stewart","year":"1998"},{"key":"b18-peds12617","series-title":"Epilepsy Behav","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.yebeh.2012.02.013","article-title":"The gelastic seizures-hypothalamic hamartoma syndrome: facts, hypotheses, and perspectives","volume":"24","author":"Striano","year":"2012"}],"container-title":["Journal of Neurosurgery: Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/12\/2\/article-p151.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/12\/2\/article-p151.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/12\/2\/article-p151.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T12:43:10Z","timestamp":1681562590000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/12\/2\/article-p151.xml"}},"subtitle":["Report of 3 cases"],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":18,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3171\/2013.4.peds12617","relation":{},"ISSN":["1933-0707","1933-0715"],"issn-type":[{"value":"1933-0707","type":"print"},{"value":"1933-0715","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8]]}}}