{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T12:52:41Z","timestamp":1782823961439,"version":"3.54.5"},"reference-count":36,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:sec>\n<jats:title>Object<\/jats:title>\n<jats:p>Stereotactic radiosurgery (SRS) is an important treatment option for patients with cavernous sinus meningiomas (CSM). To analyze factors associated with local tumor control and complications after single-fraction SRS, the authors reviewed cases involving patients treated with Gamma Knife SRS between 1990 and 2008.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Excluded were patients with WHO Grade II or III tumors, radiation-induced tumors, multiple meningiomas, neurofibromatosis Type 2, and prior or concurrent radiotherapy. Five patients were lost to follow-up and 3 patients refused research authorization. The remaining 115 patients (29 men, 86 women) had either histologically confirmed WHO Grade I (n = 46, 40%) or presumed (n = 69, 60%) CSM. The median treatment volume was 9.3 cm<jats:sup>3<\/jats:sup> (range 1.3\u201342.2 cm<jats:sup>3<\/jats:sup>). The median margin dose was 16 Gy (range 12\u201320 Gy). The median follow-up after SRS was 89 months (range 12\u2013251 months). Thirty-nine patients (34%) had 10 or more years of follow-up after SRS.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Six patients (5%) had tumor progression (in field, n = 3; marginal, n = 3) at a median of 74 months (range 42\u2013145 months) after SRS. The local tumor control rate was 99% at 5 years and 93% at 10 years after SRS. No analyzed factor was associated with local control after SRS. Fourteen patients (12%) had permanent complications at a median onset of 23 months (range 2\u2013146 months) including trigeminal dysfunction (n = 9), diplopia (n = 2), ischemic stroke (n = 2), and hypopituitarism (n = 1). The 2-year, 5-year, and 10-year rates of complications were 7%, 10%, and 15%, respectively. Multivariate analysis found larger treatment volume (HR 1.1, 95% CI 1.02\u20131.2, p = 0.01) to be associated with complications after SRS. The complication rate for patients with a treatment volume of 9.3 cm<jats:sup>3<\/jats:sup> or less was 3% (2 of 58 cases) compared with 21% (12 of 57 cases) for patients with a treatment volume greater than 9.4 cm<jats:sup>3<\/jats:sup>.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Single-fraction SRS at the radiation doses used in this series provided durable tumor control for patients with benign CSM. Larger tumor volume remains the primary factor associated with complications after single-fraction SRS of benign CSM despite advancements in SRS technique.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2013.5.jns13206","type":"journal-article","created":{"date-parts":[[2013,6,28]],"date-time":"2013-06-28T15:41:29Z","timestamp":1372434089000},"page":"675-682","source":"Crossref","is-referenced-by-count":59,"title":["Single-fraction radiosurgery of benign cavernous sinus meningiomas"],"prefix":"10.3171","volume":"119","author":[{"given":"Bruce E.","family":"Pollock","sequence":"first","affiliation":[{"name":"Departments of Neurological Surgery and"},{"name":"Radiation Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott L.","family":"Stafford","sequence":"additional","affiliation":[{"name":"Radiation Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Link","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda I.","family":"Garces","sequence":"additional","affiliation":[{"name":"Radiation Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Foote","sequence":"additional","affiliation":[{"name":"Radiation Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-jns13206","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1227\/01.NEU.0000125542.00834.6D","article-title":"Large sphenoid wing meningiomas involving the cavernous sinus: conservative surgical strategies for better functional outcomes","volume":"54","author":"Abdel-Aziz","year":"2004"},{"issue":"2 Suppl","key":"b2-jns13206","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"A7","DOI":"10.1227\/01.NEU.0000338947.84636.A6","article-title":"Cyberknife radiosurgery for benign meningiomas: short-term results in 199 patients","volume":"64","author":"Colombo","year":"2009"},{"key":"b3-jns13206","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"148","DOI":"10.3171\/jns.2006.105.1.148","article-title":"Decompression of cavernous sinus meningioma for preservation and improvement of cranial nerve function. 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