{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:28:54Z","timestamp":1790008134060,"version":"4.0.1"},"reference-count":26,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec>\n                    <jats:title>Object<\/jats:title>\n                    <jats:p>The role of parietal areas in number processing is well known. The significance of intraoperative functional mapping of these areas has been only partially explored, however, and only a few discordant data are available in the surgical literature with regard to the right parietal lobe. The purpose of this study was to evaluate the clinical impact of simple calculation in cortical electrostimulation of right-handed patients affected by a right parietal brain tumor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Calculation mapping in awake surgery was performed in 3 right-handed patients affected by high-grade gliomas located in the right parietal lobe. Preoperatively, none of the patients presented with calculation deficits. In all 3 cases, after sensorimotor and language mapping, cortical and intraparietal sulcus areas involved in single-digit multiplication and addition calculations were mapped using bipolar electrostimulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In all patients, different sites of the right parietal cortex, mainly in the inferior lobule, were detected as being specifically related to calculation (multiplication or addition). In 2 patients the intraparietal sulcus was functionally specific for multiplication. No functional sites for language were detected. All sites functional for calculation were spared during tumor resection, which was complete in all cases without postoperative neurological deficits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings provide intraoperative data in support of an anatomofunctional organization for multiplication and addition within the right parietal area. Furthermore, the study shows the potential clinical relevance of intraoperative mapping of calculation in patients undergoing surgery in the right parietal area. Further and larger studies are needed to confirm these data and assess whether mapped areas are effectively essential for function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2013.6.jns122445","type":"journal-article","created":{"date-parts":[[2013,8,9]],"date-time":"2013-08-09T10:01:55Z","timestamp":1376042515000},"page":"1107-1111","source":"Crossref","is-referenced-by-count":43,"title":["Right parietal cortex and calculation processing: intraoperative functional mapping of multiplication and addition in patients affected by a brain tumor"],"prefix":"10.3171","volume":"119","author":[{"given":"Alessandro","family":"Della Puppa","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"De Pellegrin","sequence":"additional","affiliation":[{"name":"Neuroscience, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"d'Avella","sequence":"additional","affiliation":[{"name":"Neuroscience, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Gioffr\u00e8","sequence":"additional","affiliation":[{"name":"Neuroscience, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Munari","sequence":"additional","affiliation":[{"name":"Anesthesiology and Intensive Care, University Hospital of Padova, Italy; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Saladini","sequence":"additional","affiliation":[{"name":"Neuroscience, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Salillas","sequence":"additional","affiliation":[{"name":"Basque Center on Cognition, Brain and Language, Donostia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"Scienza","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Semenza","sequence":"additional","affiliation":[{"name":"Neuroscience, and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-jns122445","series-title":"Neuropsychologia","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuropsychologia.2011.09.045","article-title":"Language in calculation: a core mechanism?","volume":"50","author":"Benn","year":"2012"},{"key":"b2-jns122445","series-title":"The Mathematical Brain","author":"Butterworth","year":"1999"},{"key":"b3-jns122445","series-title":"Fundamentals of Neural Network Modeling for Neuropsychology","first-page":"233","article-title":"Neuronal network models of acalculia and prefrontal deficits","author":"Dehaene","year":"1998"},{"key":"b4-jns122445","series-title":"Cogn Neuropsychol","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1080\/02643290244000239","article-title":"Three parietal circuits for number processing","volume":"20","author":"Dehaene","year":"2003"},{"key":"b5-jns122445","series-title":"Clin Neuropsychol","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1076\/clin.17.3.331.18092","article-title":"Number processing and calculation\u2014normative data from healthy adults","volume":"17","author":"Delazer","year":"2003"},{"key":"b6-jns122445","series-title":"Acta Neurochir (Wien)","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1007\/s007010050413","article-title":"Intra-operative direct electrical stimulations of the central nervous system: the Salp\u00eatri\u00e8re experience with 60 patients","volume":"141","author":"Duffau","year":"1999"},{"key":"b7-jns122445","series-title":"Brain","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1093\/brain\/awh423","article-title":"New insights into the anatomo-functional connectivity of the semantic system: a study using cortico-subcortical electrostimulations","volume":"128","author":"Duffau","year":"2005"},{"key":"b8-jns122445","series-title":"Ann Neurol","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1002\/1531-8249(200001)47:1<132::AID-ANA23>3.0.CO;2-0","article-title":"Intraoperative unmasking of brain redundant motor sites during resection of a precentral angioma: evidence using direct cortical stimulation","volume":"47","author":"Duffau","year":"2000"},{"key":"b9-jns122445","series-title":"The EORTC QLQ-C30 Scoring Manual","author":"Fayers","year":"2001"},{"key":"b10-jns122445","series-title":"Zh Vopr Neirokhir Im N N Burdenko","first-page":"4","article-title":"[Surgical approaches to thalamic tumors.]","volume":"75","author":"Konovalov","year":"2011"},{"key":"b11-jns122445","series-title":"Aachener Aphasie Test (AAT)\u2014Versione Italiana","author":"Luzzatti","year":"1994"},{"key":"b12-jns122445","series-title":"J Clin Neurosci","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/j.jocn.2006.01.005","article-title":"Intraventricular meningiomas: a surgical challenge","volume":"14","author":"Lyngdoh","year":"2007"},{"key":"b13-jns122445","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"770","DOI":"10.3171\/2011.5.JNS112","article-title":"Surgery for gliomas involving the left inferior parietal lobule: new insights into the functional anatomy provided by stimulation mapping in awake patients. Clinical article","volume":"115","author":"Maldonado","year":"2011"},{"key":"b14-jns122445","series-title":"Brain Struct Funct","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/s00429-011-0309-x","article-title":"Does the left superior longitudinal fascicle subserve language semantics? A brain electrostimulation study","volume":"216","author":"Maldonado","year":"2011"},{"key":"b15-jns122445","series-title":"Brain","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1093\/brain\/awl361","article-title":"Does the left inferior longitudinal fasciculus play a role in language? A brain stimulation study","volume":"130","author":"Mandonnet","year":"2007"},{"key":"b16-jns122445","series-title":"Br J Neurosurg","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1080\/02688690902721862","article-title":"Meningiomas of the lateral ventricle\u2014a report of 15 cases","volume":"23","author":"Menon","year":"2009"},{"key":"b17-jns122445","series-title":"Rev Neuropsychol (Marseille)","first-page":"73","article-title":"Standardisation d'un test de d\u00e9nomination orale. Contr\u00f4le des effets de l'\u00e2ge, du sexe et du niveau de scolarit\u00e9 chez les sujets adultes nor maux","volume":"1","author":"Metz-Lutz","year":"1991"},{"key":"b18-jns122445","series-title":"Esame Neuropsicologico Breve","author":"Mondini","year":"2003"},{"key":"b19-jns122445","series-title":"Neuropsychologia","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/0028-3932(71)90067-4","article-title":"The assessment and analysis of handedness: the Edinburgh inventory","volume":"9","author":"Oldfield","year":"1971"},{"key":"b20-jns122445","series-title":"Stereotact Funct Neurosurg","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1159\/000321186","article-title":"Cortical areas involved in numerical processing: an intraoperative electrostimulation study","volume":"89","author":"Pu","year":"2011"},{"key":"b21-jns122445","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.3171\/2008.8.JNS17649","article-title":"Cortical calculation localization using electrostimulation. Clinical article","volume":"110","author":"Roux","year":"2009"},{"key":"b22-jns122445","series-title":"Neuroimage","doi-asserted-by":"publisher","first-page":"3159","DOI":"10.1016\/j.neuroimage.2011.10.093","article-title":"Single pulse TMS induced disruption to right and left parietal cortex on addition and multiplication","volume":"59","author":"Salillas","year":"2012"},{"key":"b23-jns122445","series-title":"Neurocase","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1080\/13554794.2011.556127","article-title":"Ultra-fast recovery from right neglect after \u2018awake surgery\u2019 for slow-growing tumor invading the left parietal area","volume":"18","author":"Sallard","year":"2012"},{"key":"b24-jns122445","series-title":"Handbook of the Neuroscience of Language","first-page":"219","article-title":"Number processing","author":"Semenza","year":"2008"},{"key":"b25-jns122445","series-title":"Neuropsychologia","doi-asserted-by":"publisher","first-page":"2889","DOI":"10.1016\/j.neuropsychologia.2011.06.015","article-title":"Dissociation of subtraction and multiplication in the right parietal cortex: evidence from intraoperative cortical electrostimulation","volume":"49","author":"Yu","year":"2011"},{"key":"b26-jns122445","series-title":"Acta Psychiatr Scand","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","article-title":"The hospital anxiety and depression scale","volume":"67","author":"Zigmond","year":"1983"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/119\/5\/article-p1107.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/119\/5\/article-p1107.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/119\/5\/article-p1107.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,14]],"date-time":"2022-08-14T13:17:18Z","timestamp":1660483038000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/119\/5\/article-p1107.xml"}},"subtitle":["Clinical article"],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":26,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.3171\/2013.6.jns122445","relation":{},"ISSN":["0022-3085","1933-0693"],"issn-type":[{"value":"0022-3085","type":"print"},{"value":"1933-0693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11]]}}}