{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T15:22:50Z","timestamp":1794324170389,"version":"4.9.0"},"reference-count":20,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["SPI"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec>\n                    <jats:title>Object<\/jats:title>\n                    <jats:p>The authors undertook this study to establish an animal model to investigate the pathophysiological changes of venous hypertensive myelopathy (VHM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study was a randomized control animal study with blinded evaluation. The VHM model was developed in 24 adult New Zealand white rabbits by means of renal artery and vein anastomosis and trapping of the posterior vena cava; 12 rabbits were subjected to sham surgery. The rabbits were investigated by spinal function evaluation, abdominal aortic angiography, spinal MRI, and pathological examination of the spinal cord at different follow-up stages.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty-two (91.67%) of 24 model rabbits survived the surgery and postoperative period. The patency rate of the arteriovenous fistula was 95.45% in these 22 animals. The model rabbits had significantly decreased motor and sensory hindlimb function as well as abnormalities at the corresponding segments of the spinal cord. Pathological examination showed dilation and hyalinization of the small blood vessels, perivascular and intraparenchymal lymphocyte infiltration, proliferation of glial cells, and neuronal degeneration. Electron microscopic examination showed loose lamellar structure of the myelin sheath, increased numbers of mitochondria in the thin myelinated fibers, and pyknotic neurons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This model of VHM is stable and repeatable. Exploration of the sequential changes in spinal cord and blood vessels has provided improved understanding of this pathology, and the model may have potential for improving therapeutic results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2013.6.spine11860","type":"journal-article","created":{"date-parts":[[2013,8,16]],"date-time":"2013-08-16T10:01:55Z","timestamp":1376647315000},"page":"485-491","source":"Crossref","is-referenced-by-count":11,"title":["The pathophysiology of venous hypertensive myelopathy\u2014study of an animal model"],"prefix":"10.3171","volume":"19","author":[{"given":"Hong-Qi","family":"Zhang","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Chen","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Shuai","family":"Wu","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang-Hong","family":"Teng","sequence":"additional","affiliation":[{"name":"Pathology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Zhong","family":"Li","sequence":"additional","affiliation":[{"name":"Radiology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Yong","family":"Sun","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Ping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De-Yu","family":"Guo","sequence":"additional","affiliation":[{"name":"Experimental Animal Lab, Xuanwu Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De-Hong","family":"Lu","sequence":"additional","affiliation":[{"name":"Pathology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Ling","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-spine11860","series-title":"J Neurol Sci","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/0022-510X(74)90229-9","article-title":"The pathophysiology of spinal vascular malformations","volume":"23","author":"Aminoff","year":"1974"},{"key":"b2-spine11860","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1227\/01.NEU.0000137630.50959.A7","article-title":"Spinal dural arteriovenous fistulae: analysis of outcome in relation to pretreatment indicators","volume":"55","author":"Cenzato","year":"2004"},{"key":"b3-spine11860","series-title":"Rev Neurol (Paris)","first-page":"1","article-title":"[Subacute necrotic myelitis, slowly progressive central myelitis with vascular hyperplasia, and slowly ascending, increasingly flaccid amyotrophic paraplegia accompanied by albuminocytologic dissociation.]","volume":"33","author":"Foix","year":"1926"},{"key":"b4-spine11860","series-title":"Neurosurg Rev","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/BF00309983","article-title":"Flow velocity and pressure measurements in spinal dural arteriovenous fistulas","volume":"17","author":"Hassler","year":"1994"},{"key":"b5-spine11860","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"360","DOI":"10.3171\/jns.1989.70.3.0360","article-title":"Hemodynamics of spinal dural arteriovenous fistulas. 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