{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T18:58:11Z","timestamp":1785869891448,"version":"3.56.0"},"reference-count":43,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec>\n<jats:title>Object<\/jats:title>\n<jats:p>Although essential arterial hypertension (AH) represents a major health issue, its underlying causes remain unknown. An intriguing hypothesis is that AH in some cases may be caused by vascular compression of the rostral ventrolateral medulla (RVLM). Because hemifacial spasms (HFSs) are caused by vascular compression of the seventh cranial nerve in close proximity to the RVLM, one would, if this hypothesis is correct, expect to find a positive association between the occurrence of AH and chronic HFSs. Such a positive association would not be expected in patients with trigeminal neuralgia (TN), since TN is caused by vascular compression of the fifth cranial nerve, which is not close to the RVLM.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>In view of this background, the authors conducted a retrospective population-based study to investigate how the occurrence of AH in patients with either HFSs or TN compares with the prevalence of AH in the general population, when adjusted for sex and age. The general population was represented by participants of the Nord-Tr\u00f8ndelag Health Study 3 (HUNT3).<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>The prevalence of AH in the authors' patients with HFSs was significantly higher than in a sex- and age-adjusted sample from the general population; this was not true for the patients with TN.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The authors suggest that the data provide supporting evidence to the theory that compression of the RVLM may be one cause of AH.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2013.7.jns13231","type":"journal-article","created":{"date-parts":[[2013,8,30]],"date-time":"2013-08-30T14:02:29Z","timestamp":1377871349000},"page":"1302-1308","source":"Crossref","is-referenced-by-count":15,"title":["Hypertension in patients with cranial nerve vascular compression syndromes and comparison with a population-based cohort"],"prefix":"10.3171","volume":"119","author":[{"given":"Tiril","family":"Sandell","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Oslo University Hospital\u2013Rikshospitalet;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jostein","family":"Holmen","sequence":"additional","affiliation":[{"name":"HUNT Research Centre, Faculty of Medicine, Norwegian University of Science and Technology, Levanger; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per Kristian","family":"Eide","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Oslo University Hospital\u2013Rikshospitalet;"},{"name":"Faculty of Medicine, University of Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-jns13231","series-title":"AJNR Am J Neuroradiol","first-page":"401","article-title":"Essential hypertension and neurovascular compression at the ventrolateral medulla oblongata: MR evaluation","volume":"16","author":"Akimura","year":"1995"},{"key":"b2-jns13231","series-title":"Hypertens Res","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1038\/hr.2009.80","article-title":"Efficacy of an L- and N-type calcium channel blocker in hypertensive patients with neurovascular compression of the rostral ventrolateral medulla","volume":"32","author":"Aota","year":"2009"},{"key":"b3-jns13231","series-title":"J Clin Endocrinol Metab","doi-asserted-by":"publisher","first-page":"1862","DOI":"10.1210\/jcem.84.6.5724","article-title":"Hypertension in women","volume":"84","author":"August","year":"1999"},{"key":"b4-jns13231","series-title":"N Engl J Med","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1056\/NEJM199604253341701","article-title":"The long-term outcome of microvascular decompression for trigeminal neuralgia","volume":"334","author":"Barker","year":"1996"},{"key":"b5-jns13231","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"201","DOI":"10.3171\/jns.1995.82.2.0201","article-title":"Microvascular decompression for hemifacial spasm","volume":"82","author":"Barker","year":"1995"},{"key":"b6-jns13231","series-title":"Hypertension","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1161\/01.HYP.25.3.305","article-title":"Prevalence of hypertension in the US adult population. 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