{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T05:00:49Z","timestamp":1781067649176,"version":"3.54.1"},"reference-count":126,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FOC"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:p>Tourette's syndrome (TS) is a childhood neuropsychiatric disorder characterized by multiple involuntary motor and vocal tics. It is commonly associated with other behavioral disorders including attention-deficit\/hyperactivity disorder, obsessive-compulsive disorder, anxiety, depression, and self-injurious behaviors. Tourette's syndrome can be effectively managed with psychobehavioral and pharmacological treatments, and many patients experience an improvement in tics in adulthood. However, symptoms may persist and cause severe impairment in a small subset of patients despite available therapies. In recent years, deep brain stimulation (DBS) has been shown to be a promising treatment option for such patients. Since the advent of its use in 1999, multiple targets have been identified in DBS for TS, including the medial thalamus, globus pallidus internus, globus pallidus externus, anterior limb of the internal capsule\/nucleus accumbens, and subthalamic nucleus. While the medial thalamus is the most commonly reported trajectory, the optimal surgical target for TS is still a topic of much debate. This paper provides a review of the available literature regarding the use of DBS for TS.<\/jats:p>","DOI":"10.3171\/2013.8.focus13292","type":"journal-article","created":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T05:09:19Z","timestamp":1383282559000},"page":"E4","source":"Crossref","is-referenced-by-count":15,"title":["The use of deep brain stimulation in Tourette's syndrome"],"prefix":"10.3171","volume":"35","author":[{"given":"Janine","family":"Rotsides","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, Rutgers New Jersey Medical School, Newark, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonios","family":"Mammis","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Rutgers New Jersey Medical School, Newark, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-0350004","series-title":"J Neurol Neurosurg 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male patient with Gilles de la Tourette's syndrome","volume":"17","author":"Van der Linden","year":"2002"},{"key":"b60-0350004","series-title":"Lancet","first-page":"724","article-title":"Stereotactic treatment of Gilles de la Tourette syndrome by high frequency stimulation of thalamus","volume":"353","author":"Vandewalle","year":"1999"},{"key":"b61-0350004","series-title":"J Neurosurg","first-page":"1094","article-title":"Chronic bilateral thalamic stimulation: a new therapeutic approach in intractable Tourette syndrome. 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treatment","volume":"123","author":"Robertson","year":"2000"},{"key":"b48-0350004","series-title":"Mol Psychiatry","first-page":"495","article-title":"The Dimensional Yale-Brown Obsessive-Compulsive Scale (DY-BOCS): an instrument for assessing obsessive-compulsive symptom dimensions","volume":"11","author":"Rosario-Campos","year":"2006"},{"key":"b49-0350004","series-title":"BMJ Case Rep","first-page":"bcr2012006579","article-title":"Bilateral deep brain stimulation of the nucleus accumbens for comorbid obsessive-compulsive disorder and Tourette's syndrome","volume":"2012","author":"Sachdev","year":"2012"},{"key":"b50-0350004","series-title":"Brain Res Bull","first-page":"122","article-title":"The primate centromedian-parafascicular complex: anatomical organization with a note on neuromodulation","volume":"78","author":"Sadikot","year":"2009"},{"key":"b51-0350004","series-title":"Mayo Clin Proc","first-page":"59","article-title":"Deep brain stimulation in Tourette syndrome: a 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