{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T04:53:00Z","timestamp":1777006380970,"version":"3.51.4"},"reference-count":55,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PED"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec>\n<jats:title>Object<\/jats:title>\n<jats:p>Subependymal giant cell astrocytomas (SEGAs) are benign tumors, most commonly associated with tuberous sclerosis complex (TSC). The vast majority of these tumors arise from the lateral ependymal surface adjacent to the foramen of Monro, therefore potentially encroaching on one or both foramina, and resulting in obstructive hydrocephalus that necessitates surgical decompression. The indications for surgery, intraoperative considerations, and evolution of the authors' management paradigm are presented.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Patients with TSC who underwent craniotomy for SEGA resection at New York University Langone Medical Center between January 1997 and March 2011 were identified. Preoperative imaging, clinical characteristics, management decisions, operative procedures, and outcomes were reviewed.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Eighteen patients with TSC underwent 22 primary tumor resections for SEGAs. The indication for surgery was meaningful radiographic tumor progression in 16 of 21 cases. The average age at the time of operation was 10.3 years. Average follow-up duration was 52 months (range 12\u2013124 months). The operative approach was intrahemispheric-transcallosal in 16 cases, transcortical-transventricular in 5, and neuroendoscopic in 1. Nine tumors were on the right, 9 on the left, and 3 were bilateral. Gross-total resection was documented in 16 of 22 cases in our series, with radical subtotal resection achieved in 4 cases, and subtotal resection (STR) in 2 cases. Two patients had undergone ventriculoperitoneal shunt placement preoperatively and 7 patients required shunt placement after surgery for moderate to severe ventriculomegaly. Two patients experienced tumor progression requiring reoperation; both of these patients had initially undergone STR.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The authors present their management strategy for TSC patients with SEGAs. Select patients underwent microsurgical resection of SEGAs with acceptable morbidity. Gross-total resection or radical STR was achieved in 90.9% of our series (20 of 22 primary tumor resections), with no recurrences in this group. Approximately half of our patient series required CSF diversionary procedures. There were no instances of permanent neurological morbidity associated with surgery.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2013.9.peds13193","type":"journal-article","created":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T13:57:50Z","timestamp":1383314270000},"page":"21-28","source":"Crossref","is-referenced-by-count":32,"title":["A management strategy for intraventricular subependymal giant cell astrocytomas in tuberous sclerosis complex"],"prefix":"10.3171","volume":"13","author":[{"given":"David H.","family":"Harter","sequence":"first","affiliation":[{"name":"Department of Neurosurgery,"},{"name":"Division of Pediatric Neurosurgery, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Bassani","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaun D.","family":"Rodgers","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Roth","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orrin","family":"Devinsky","sequence":"additional","affiliation":[{"name":"The Comprehensive Epilepsy Center, New York University Langone Medical Center, New York, New York; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chad","family":"Carlson","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Medical College of Wisconsin, Milwaukee, Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffery H.","family":"Wisoff","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery,"},{"name":"Division of Pediatric Neurosurgery, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard L.","family":"Weiner","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery,"},{"name":"Division of Pediatric Neurosurgery, and"},{"name":"The Comprehensive Epilepsy Center, New York University Langone Medical Center, New York, New York; and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-peds13193","series-title":"Eur J Neurol","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1111\/j.1468-1331.2009.02567.x","article-title":"Prevalence of subependymal giant cell tumors in patients with tuberous sclerosis and a review of the literature","volume":"16","author":"Adriaensen","year":"2009"},{"key":"b2-peds13193","series-title":"Eur J Paediatr Neurol","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.ejpn.2012.10.005","article-title":"The outcome of surgical management of subependymal giant cell astrocytoma in tuberous sclerosis complex","volume":"17","author":"Amin","year":"2013"},{"key":"b3-peds13193","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1227\/00006123-198205000-00001","article-title":"Transcallosal, interfornicial approaches for lesions affecting the third ventricle: surgical considerations and consequences","volume":"10","author":"Apuzzo","year":"1982"},{"key":"b4-peds13193","series-title":"Clin Neurol Neurosurg","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1016\/j.clineuro.2005.10.009","article-title":"Complications of interhemispheric transcallosal approach in children: review of 15 years experience","volume":"108","author":"Aryan","year":"2006"},{"key":"b5-peds13193","series-title":"Neurosurg Rev","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1007\/s10143-002-0239-4","article-title":"Transcortical or transcallosal approach to ventricle-associated lesions: a clinical study on the prognostic role of surgical approach","volume":"26","author":"Asgari","year":"2003"},{"key":"b6-peds13193","series-title":"J Neurosurg Pediatr","doi-asserted-by":"publisher","first-page":"381","DOI":"10.3171\/2010.7.PEDS10221","article-title":"Rapamycin as an alternative to surgical treatment of subependymal giant cell astrocytomas in a patient with tuberous sclerosis complex. 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