{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T18:18:01Z","timestamp":1774462681411,"version":"3.50.1"},"reference-count":36,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PED"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec>\n<jats:title>OBJECT<\/jats:title>\n<jats:p>The treatment for giant posterior fossa cystic craniopharyngiomas remains an important challenge in neurosurgery. The authors evaluated the effects of treating 20 patients with giant posterior fossa cystic craniopharyngiomas using phosphorus-32 (P-32) interstitial radiotherapy at their hospital.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>The patients included 11 boys and 9 girls with an age range of 3 to 168 months. Before treatment, the tumor volumes ranged from 65 to 215 ml. The intracranial pressure was increased in 16 patients, and optic nerve damage had occurred in 18. The patients received P-32 interstitial radiotherapy following stereotactic cyst-fluid aspiration or drainage and were followed up for 7\u2013138 months.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>The treatment immediately relieved the intracranial hypertension symptoms in all patients. At the end of follow-up, imaging examinations revealed that the cystic tumors had disappeared, but some residual calcification remained in 12 patients, and had decreased by more than 75% of the initial volume in 8 patients. The damaged optic nerve recovered in 3 cases, improved in 12 cases, remained unchanged in 1 case, and was aggravated in 2 cases. No other severe complications related to surgery or interstitial radiation occurred. During the follow-up period, 7 new cysts appeared in 5 patients who had received additional interstitial radiotherapies with a dose of P-32 that was calculated using the same formula as for the initial treatment. The new tumors then disappeared in 2 patients, significantly shrank in 2 patients, and progressed in 1 patient.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>For treating giant posterior fossa cystic craniopharyngiomas, P-32 interstitial radiation after stereotactic cyst-fluid aspiration or drainage can achieve a high tumor control rate and has relatively satisfactory clinical effects and quality of life outcomes with few complications.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2014.10.peds14302","type":"journal-article","created":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T14:58:26Z","timestamp":1423839506000},"page":"510-518","source":"Crossref","is-referenced-by-count":12,"title":["Interstitial radiotherapy using phosphorus-32 for giant posterior fossa cystic craniopharyngiomas"],"prefix":"10.3171","volume":"15","author":[{"given":"Xin","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Navy General Hospital, Beijing;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianning","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Navy General Hospital, Beijing;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Navy General Hospital, Beijing;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Navy General Hospital, Beijing;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Navy General Hospital, Beijing;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Navy General Hospital, Beijing;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Navy General Hospital, Beijing;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing Neurosurgical Institute and Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; and"},{"name":"UMR 788, INSERM et Universit\u00e9 Paris-Sud, Le Kremlin-Bic\u00eatre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-peds14302","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1227\/00006123-198510000-00009","article-title":"Microsurgery for giant craniopharyngiomas in children","volume":"17","author":"Al-Mefty","year":"1985"},{"key":"b2-peds14302","series-title":"Radiother Oncol","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.radonc.2010.12.001","article-title":"Phosphorus-32 therapy for cystic craniopharyngiomas","volume":"98","author":"Barriger","year":"2011"},{"key":"b3-peds14302","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1007\/s003810050480","article-title":"Giant cystic craniopharyngiomas with extension into the posterior fossa","volume":"16","author":"Buhl","year":"2000"},{"key":"b4-peds14302","series-title":"Acta Neurochir (Wien)","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1007\/s007010050123","article-title":"Management of recurrent craniopharyngioma","volume":"140","author":"Caldarelli","year":"1998"},{"key":"b5-peds14302","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1227\/00006123-198209000-00008","article-title":"Craniopharyngiomas in children","volume":"11","author":"Carmel","year":"1982"},{"key":"b6-peds14302","series-title":"Surg Neurol","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/S0090-3019(96)00253-4","article-title":"Giant posterior fossa cystic craniopharyngiomas presenting with hearing loss. 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