{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T14:27:31Z","timestamp":1777300051957,"version":"3.51.4"},"reference-count":11,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["SPI"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:p>Surgical lysis of the thickened arachnoid membrane is the first choice of treatment in spinal arachnoid pathologies that cause flow disturbances or blockage of CSF. However, it is important to consider that while extensive lysis of the arachnoid may temporarily provide a wide pathway for CSF, an extensive lytic procedure may later cause secondary adhesion. Thus, it is ideal for the proper extent of the arachnoid lysis to be determined after careful analysis of regional CSF flow. The authors report their limited experience with intraoperative visualization of CSF flow in spinal arachnoid pathologies. Two patients with a dorsal arachnoid web (DAW) with cervical syringomyelia and 1 patient with focal adhesive arachnoiditis causing edema of the spinal cord were surgically treated at the authors' institution between 2007 and 2013. In all cases, the presence of a DAW or focal adhesive arachnoiditis was suspected from the findings on MRI, namely 1) an indentation on the upper thoracic spinal cord and 2) syringomyelia and\/or edema of the spinal cord above the indentation. Exploratory surgery disclosed a transversely thickened arachnoid septum on the dorsal side of the indented cord. To prove blockage of the CSF by the septum and to decide on the extent of arachnoid lysis, regional CSF flow around the arachnoid septum was visualized by subarachnoid injection of gentian violet solution close to the web. Injected dye stagnated just close to the arachnoid septum in all cases, and these findings documented CSF blockage by the septum. In 2 cases, a 2-minute observation showed that the injected dye stayed close to the web without diffusion. The authors performed not only resection of the web itself but also lysis of the thickened arachnoid on both sides of the spinal cord to make a CSF pathway on the ventral side. In the third case, the dye stagnated close to the web at first but then diffused through the nerve root to the ventral CSF space. The lysis procedure was completed after exclusive removal of the dorsal web. Postoperative MR images confirmed reduction of the syrinx and\/or improvement of the edema in all cases, suggesting that the extent of arachnoid lysis was optimal in each case. No adverse effect was observed after subarachnoid injection of gentian violet. The authors believe that their technique of visualizing regional CSF flow will be helpful to decide the optimal extent of lysis in some local arachnoid pathologies.<\/jats:p>","DOI":"10.3171\/2014.10.spine1446","type":"journal-article","created":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T15:03:17Z","timestamp":1423839797000},"page":"554-557","source":"Crossref","is-referenced-by-count":33,"title":["Visualization of regional cerebrospinal fluid flow with a dye injection technique in focal arachnoid pathologies"],"prefix":"10.3171","volume":"22","author":[{"given":"Satoshi","family":"Yamaguchi","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazutoshi","family":"Hida","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Sapporo Azabu Neurosurgical Hospital, Sapporo, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takafumi","family":"Mitsuhara","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mizuki","family":"Morishige","sequence":"additional","affiliation":[{"name":"Division of Clinical Engineering, Hiroshima University Hospital, Hiroshima; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoto","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaoru","family":"Kurisu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-spine1446","series-title":"Acta Neurochir (Wien)","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1007\/s00701-003-0071-9","article-title":"Syringomyelia and the arachnoid web","volume":"145","author":"Brodbelt","year":"2003"},{"key":"b2-spine1446","series-title":"J Neurosurg Spine","doi-asserted-by":"publisher","first-page":"30","DOI":"10.3171\/2013.9.SPINE1323","article-title":"Surgical manifestations of thoracic arachnoid pathology: series of 28 cases","volume":"20","author":"Griessenauer","year":"2014"},{"key":"b3-spine1446","series-title":"Neurol Med Chir (Tokyo)","doi-asserted-by":"publisher","first-page":"686","DOI":"10.2176\/nmc.52.686","article-title":"Syringomyelia and arachnoid cysts associated with spinal arachnoiditis following subarachnoid hemorrhage","volume":"52","author":"Ishizaka","year":"2012"},{"key":"b4-spine1446","series-title":"Neurosurgery","first-page":"1109","article-title":"Visualization of the ostium of an arteriotomy in bypass surgery","volume":"33","author":"Kamiyama","year":"1993"},{"key":"b5-spine1446","series-title":"Exp Dermatol","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1111\/exd.12257","article-title":"Gentian violet: a 19th century drug re-emerges in the 21st century","volume":"22","author":"Maley","year":"2013"},{"key":"b6-spine1446","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1227\/01.NEU.0000334411.93870.45","article-title":"Cardiac-gated phase-contrast magnetic resonance imaging of cerebrospinal fluid flow in the diagnosis of idiopathic syringomyelia","volume":"63","author":"Mauer","year":"2008"},{"key":"b7-spine1446","series-title":"J Clin Neurosci","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1054\/jocn.2000.0731","article-title":"Surgical management of syringomyelia associated with spinal adhesive arachnoiditis","volume":"8","author":"Ohata","year":"2001"},{"key":"b8-spine1446","series-title":"J Neurosurg (2 Suppl)","first-page":"287","article-title":"Dorsal arachnoid web with spinal cord compression: variant of an arachnoid cyst? 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