{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T02:24:54Z","timestamp":1781576694223,"version":"3.54.5"},"reference-count":32,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2015,11]]},"abstract":"\nOBJECT<\/jats:title>\nStereotactic radiosurgery (SRS) is a potentially important option for patients with skull base chondrosarcomas. The object of this study was to analyze the outcomes of SRS for chondrosarcoma patients who underwent this treatment as a part of multimodality management.<\/jats:p><\/jats:sec>\n\nMETHODS<\/jats:title>\nSeven participating centers of the North American Gamma Knife Consortium (NAGKC) identified 46 patients who underwent SRS for skull base chondrosarcomas. Thirty-six patients had previously undergone tumor resections and 5 had been treated with fractionated radiation therapy (RT). The median tumor volume was 8.0 cm3<\/jats:sup> (range 0.9\u201328.2 cm3<\/jats:sup>), and the median margin dose was 15 Gy (range 10.5\u201320 Gy). Kaplan-Meier analysis was used to calculate progression-free and overall survival rates.<\/jats:p><\/jats:sec>\n\nRESULTS<\/jats:title>\nAt a median follow-up of 75 months after SRS, 8 patients were dead. The actuarial overall survival after SRS was 89% at 3 years, 86% at 5 years, and 76% at 10 years. Local tumor progression occurred in 10 patients. The rate of progression-free survival (PFS) after SRS was 88% at 3 years, 85% at 5 years, and 70% at 10 years. Prior RT was significantly associated with shorter PFS. Eight patients required salvage resection, and 3 patients (7%) developed adverse radiation effects. Cranial nerve deficits improved in 22 (56%) of the 39 patients who deficits before SRS. Clinical improvement after SRS was noted in patients with abducens nerve paralysis (61%), oculomotor nerve paralysis (50%), lower cranial nerve dysfunction (50%), optic neuropathy (43%), facial neuropathy (38%), trochlear nerve paralysis (33%), trigeminal neuropathy (12%), and hearing loss (10%).<\/jats:p><\/jats:sec>\n\nCONCLUSIONS<\/jats:title>\nStereotactic radiosurgery for skull base chondrosarcomas is an important adjuvant option for the treatment of these rare tumors, as part of a team approach that includes initial surgical removal of symptomatic larger tumors.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2014.12.jns132580","type":"journal-article","created":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T14:00:25Z","timestamp":1435327225000},"page":"1268-1275","source":"Crossref","is-referenced-by-count":43,"title":["Skull base chondrosarcoma radiosurgery: report of the North American Gamma Knife Consortium"],"prefix":"10.3171","volume":"123","author":[{"given":"Hideyuki","family":"Kano","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Sheehan","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penny K.","family":"Sneed","sequence":"additional","affiliation":[{"name":"Departments of Radiation Oncology and Neurological Surgery, University of California, San Francisco, San Francisco, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heyoung L.","family":"McBride","sequence":"additional","affiliation":[{"name":"Departments of Radiation Oncology and Neurological Surgery, Barrow Neurological Institute, Phoenix, Arizona;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byron","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Kentucky, Lexington, Kentucky;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Duma","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Hoag Memorial Hospital, Newport Beach, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Mathieu","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Universit\u00e9 de Sherbrooke, Centre de Recherche Clinique \u00c9tienne-LeBel, Sherbrooke, Quebec, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary","family":"Seymour","sequence":"additional","affiliation":[{"name":"Departments of Radiation Oncology and Neurological Surgery, University of California, San Francisco, San Francisco, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"McDermott","sequence":"additional","affiliation":[{"name":"Departments of Radiation Oncology and Neurological Surgery, University of California, San Francisco, San Francisco, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Kondziolka","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, New York University Langone Medical Center, New York, New York; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya","family":"Iyer","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Stanford University, Stanford, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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