{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T12:16:14Z","timestamp":1771676174839,"version":"3.50.1"},"reference-count":41,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:p>Animal studies have shown that <jats:italic>Listeria monocytogenes<\/jats:italic> can probably access the brain through a peripheral intraneural route, and it has been suggested that a similar process may occur in humans. However, thus far, its spreading through the central nervous system (CNS) has not been completely elucidated. The authors present a case of multiple L. <jats:italic>monocytogenes<\/jats:italic> cerebral abscesses characterized by a pattern of distribution that suggested spread along white matter fiber tracts and reviewed the literature to identify other cases for analysis. They elected to include only those cases with 3 or more cerebral abscesses to make sure that the distribution was not random, but rather followed a pattern. In addition, they included those cases with abscesses in both the brainstem and the cerebral hemispheres, but excluded cases in which abscesses were located solely in the brainstem.<\/jats:p>\n<jats:p>Of 77 cases of L. <jats:italic>monocytogenes<\/jats:italic> CNS abscesses found in the literature, 17 involved multiple abscesses. Of those, 6 were excluded for lack of imaging and 3 because they involved only the brainstem. Of the 8 remaining cases from the literature, one was a case of bilateral abscesses that did not follow a fiber tract; another was also bilateral, but with lesions appearing to follow fiber tracts on one side; and in the remaining 6, to which the authors added their own case for a total of 7, all the abscesses were located exclusively in the same hemisphere and distributed along white matter fiber tracts.<\/jats:p>\n<jats:p>The findings suggest that after entering the CNS, L. <jats:italic>monocytogenes<\/jats:italic> travels within the axons, resulting in a characteristic pattern of distribution of multiple abscesses along the white matter fiber tracts in the brain. This report is the first description suggesting intraaxonal CNS spread of L. <jats:italic>monocytogenes<\/jats:italic> infection in humans following its entry into the brain. This distinct pattern is clearly seen on imaging and its recognition may be valuable in the diagnosis of listeriosis. This finding may allow for earlier diagnosis, which may improve outcome.<\/jats:p>","DOI":"10.3171\/2014.12.jns142100","type":"journal-article","created":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T14:00:09Z","timestamp":1434722409000},"page":"1593-1599","source":"Crossref","is-referenced-by-count":25,"title":["Spreading of multiple Listeria monocytogenes abscesses via central nervous system fiber tracts: case report"],"prefix":"10.3171","volume":"123","author":[{"given":"Michel W.","family":"Bojanowski","sequence":"first","affiliation":[{"name":"Divisions of Neurosurgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romuald","family":"Seizeur","sequence":"additional","affiliation":[{"name":"Divisions of Neurosurgery and"},{"name":"Service de Neurochirurgie, CHRU de Brest, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khaled","family":"Effendi","sequence":"additional","affiliation":[{"name":"Divisions of Neurosurgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Bourgouin","sequence":"additional","affiliation":[{"name":"Divisions of Neurosurgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsa","family":"Magro","sequence":"additional","affiliation":[{"name":"Divisions of Neurosurgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Letourneau-Guillon","sequence":"additional","affiliation":[{"name":"Neuroradiology, H\u00f4pital Notre Dame, Montr\u00e9al, Quebec, Canada; and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-jns142100","series-title":"Eur Radiol","first-page":"188","article-title":"Cerebritis due to Listeria monocytogenes: CT and MR findings","volume":"6","author":"Aladro","year":"1996"},{"key":"b2-jns142100","series-title":"Brain Pathol","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1111\/j.1750-3639.2001.tb00411.x","article-title":"Evidence for intraaxonal spread of Listeria monocytogenes from the periphery to the central nervous system","volume":"11","author":"Antal","year":"2001"},{"key":"b3-jns142100","series-title":"Clin Infect Dis","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1093\/clind\/16.5.689","article-title":"Brainstem encephalitis (rhombencephalitis) due to Listeria monocytogenes: case report and review","volume":"16","author":"Armstrong","year":"1993"},{"key":"b4-jns142100","series-title":"Pediatr Infect Dis J","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1097\/00006454-199903000-00024","article-title":"Brain abscess associated with neonatal listeriosis","volume":"18","author":"Banerji","year":"1999"},{"key":"b5-jns142100","series-title":"Rev Infect Dis","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1093\/clinids\/13.1.115","article-title":"Listeriosis in patients infected with human immunodeficiency virus","volume":"13","author":"Berenguer","year":"1991"},{"key":"b6-jns142100","series-title":"Neurol Med Chir (Tokyo)","doi-asserted-by":"publisher","first-page":"263","DOI":"10.2176\/nmc.53.263","article-title":"Stereotactic biopsy and drainage of a brainstem abscess caused by Listeria monocytogenes","volume":"53","author":"Beynon","year":"2013"},{"key":"b7-jns142100","series-title":"Vet Pathol","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1177\/030098587701400501","article-title":"Spontaneous listeric encephalitis in sheep. 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