{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T17:47:47Z","timestamp":1759600067765},"reference-count":22,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:p>In this paper, a rare case of subependymoma of the fourth ventricle in identical female twins is reported. Magnetic resonance imaging and CT showed nearly identical locations of the tumors in the fourth ventricle and similar growth patterns of the tumors in both sisters. Likewise, postoperative histopathological analysis of both tumors revealed the typical histological appearance of subependymomas. Subependymoma is a rare, low-grade glioma of the CNS, slowly growing and usually asymptomatic. If symptomatic, a subependymoma can in some cases lead to sudden death caused by pressure on the brainstem or decompensated secondary hydrocephalus. This case demonstrates the importance of detecting tumors early and thereby preventing symptoms arising from increasing intracranial pressure, and optimizing therapy options.<\/jats:p>","DOI":"10.3171\/2014.2.jns122179","type":"journal-article","created":{"date-parts":[[2014,3,21]],"date-time":"2014-03-21T14:33:56Z","timestamp":1395412436000},"page":"570-575","source":"Crossref","is-referenced-by-count":5,"title":["Simultaneous subependymomas in monozygotic female twins: further evidence for a common genetic or developmental disorder background"],"prefix":"10.3171","volume":"121","author":[{"given":"Susan","family":"Noell","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudi","family":"Beschorner","sequence":"additional","affiliation":[{"name":"Neuropathology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sotirios","family":"Bisdas","sequence":"additional","affiliation":[{"name":"Neuroradiology, University of Tuebingen;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"Beyer","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, Hannover Medical School, Hannover; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruthild G.","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, Hannover Medical School, Hannover; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"Fallier-Becker","sequence":"additional","affiliation":[{"name":"Neuropathology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rainer","family":"Ritz","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"},{"name":"Department of Neurosurgery, University of Marburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-jns122179","series-title":"Acta Neurochir (Wien)","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/BF01407172","article-title":"Surgical treatment of subependymomas of the central nervous system. Report of 8 cases and review of the literature","volume":"98","author":"Artico","year":"1989"},{"key":"b2-jns122179","series-title":"Dtsch Z Nervenheilk","first-page":"49","article-title":"\u00dcber zwei F\u00e4lle von Gehirntumor (H\u00e4mangiosarkom oder sog. Periepitheliom in der Gegend des 3 Ventrikels) bei zwei Geschwistern","volume":"8","author":"Besold","year":"1896"},{"key":"b3-jns122179","series-title":"Neurosurgery","first-page":"145","article-title":"Simultaneous presentation of symptomatic subependymomas in siblings: case reports and review","volume":"33","author":"Cheng","year":"1993"},{"key":"b4-jns122179","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"655","DOI":"10.3171\/jns.1979.50.5.0655","article-title":"Simultaneous clinical manifestation of subependymoma of the fourth ventricle in identical twins. Case report","volume":"50","author":"Clarenbach","year":"1979"},{"key":"b5-jns122179","series-title":"J Neurosurg Pediatr","doi-asserted-by":"publisher","first-page":"263","DOI":"10.3171\/2009.10.PEDS09240","article-title":"Pediatric brain tumors: genetics and clinical outcome. Clinical article","volume":"5","author":"Faria","year":"2010"},{"key":"b6-jns122179","series-title":"Neuroradiology","first-page":"269","article-title":"Osborn, Salzman, Barkovich et al: Diagnostic Imaging: Brain. 2nd Edition","volume":"54","author":"Forbes","year":"2012"},{"key":"b7-jns122179","series-title":"AJNR Am J Neuroradiol","first-page":"2121","article-title":"MR manifestations of subependymomas","volume":"16","author":"Hoeffel","year":"1995"},{"key":"b8-jns122179","series-title":"Br J Neurosurg","doi-asserted-by":"publisher","first-page":"317","DOI":"10.3109\/02688698709023773","article-title":"Familial subependymomas","volume":"1","author":"Honan","year":"1987"},{"key":"b9-jns122179","series-title":"Acta Neuropathol","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1007\/s00401-003-0739-5","article-title":"Human ependymomas reveal frequent deletions on chromosomes 6 and 9","volume":"106","author":"Huang","year":"2003"},{"key":"b10-jns122179","series-title":"J Neurooncol","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1023\/A:1021204616334","article-title":"Clinicopathological study of seven cases of symptomatic supratentorial subependymoma","volume":"61","author":"Im","year":"2003"},{"key":"b11-jns122179","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"508","DOI":"10.3171\/jns.1985.62.4.0508","article-title":"Subependymomas of the fourth ventricle. Surgical treatment in 12 cases","volume":"62","author":"Jooma","year":"1985"},{"key":"b12-jns122179","series-title":"Brain Pathol","first-page":"469","article-title":"Genome-wide analysis of subependymomas shows underlying chromosomal copy number changes involving chromosomes 6, 7, 8 and 14 in a proportion of cases","volume":"18","author":"Kurian","year":"2008"},{"key":"b13-jns122179","series-title":"Atlas Klinische Neuroradiologie des Gehirns","author":"Linn","year":"2011"},{"key":"b14-jns122179","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1227\/00006123-198610000-00014","article-title":"Symptomatic subependymoma: report of four new cases studied with computed tomography and review of the literature","volume":"19","author":"Lobato","year":"1986"},{"key":"b15-jns122179","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"583","DOI":"10.3171\/jns.1991.75.4.0583","article-title":"Symptomatic subependymoma: a clinicopathological and flow cytometric study","volume":"75","author":"Lombardi","year":"1991"},{"key":"b16-jns122179","series-title":"WHO Classification of Tumours of the Central Nervous System","first-page":"70","article-title":"Subependymoma","author":"McLendon","year":"2007"},{"key":"b17-jns122179","series-title":"Am J Forensic Med Pathol","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1097\/00000433-200203000-00014","article-title":"Sudden unexpected death resulting from previously nonsymptomatic subependymoma","volume":"23","author":"Ortiz-Reyes","year":"2002"},{"key":"b18-jns122179","series-title":"Genes Chromosomes Cancer","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1002\/(SICI)1098-2264(199903)24:3<230::AID-GCC8>3.0.CO;2-C","article-title":"Chromosome arm 6q loss is the most common recurrent autosomal alteration detected in primary pediatric ependymoma","volume":"24","author":"Reardon","year":"1999"},{"key":"b19-jns122179","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.3171\/jns.1994.80.6.1108","article-title":"Familial occurrence of subependymoma. Report of two cases","volume":"80","author":"Ryken","year":"1994"},{"key":"b20-jns122179","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"689","DOI":"10.3171\/jns.1978.49.5.0689","article-title":"Symptomatic subependymoma. Report of 21 cases with review of the literature","volume":"49","author":"Scheithauer","year":"1978"},{"key":"b21-jns122179","series-title":"Childs Nerv Syst","first-page":"177","article-title":"Histologic prognostic factors in ependymoma","volume":"7","author":"Schiffer","year":"1991"},{"key":"b22-jns122179","series-title":"Cancer Genet Cytogenet","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/S0165-4608(00)00265-X","article-title":"Comparative genomic hybridization detects losses of chromosomes 22 and 16 as the most common recurrent genetic alterations in primary ependymomas","volume":"122","author":"Zheng","year":"2000"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/121\/3\/article-p570.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/121\/3\/article-p570.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/121\/3\/article-p570.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T01:39:46Z","timestamp":1658713186000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/121\/3\/article-p570.xml"}},"subtitle":["Report of 2 cases"],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":22,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.3171\/2014.2.jns122179","relation":{},"ISSN":["0022-3085","1933-0693"],"issn-type":[{"value":"0022-3085","type":"print"},{"value":"1933-0693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9]]}}}