{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:27:18Z","timestamp":1761823638388},"reference-count":28,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PED"],"published-print":{"date-parts":[[2014,6]]},"abstract":"\nObject<\/jats:title>\nSufficient data on surgical treatment and seizure outcome of pediatric patients with different types of epilepsy, especially drug-resistant epilepsy and associated cerebral cavernous malformations, are scarce. The aim of this study was to carefully evaluate seizure outcome using the International League Against Epilepsy (ILAE) classification with regard to the presurgical symptom duration.<\/jats:p><\/jats:sec>\n\nMethods<\/jats:title>\nFifty-one pediatric patients younger than 19 years with cerebral cavernous malformations of all CNS localizations have been surgically treated at the authors' institution. Twenty-two patients with seizures or epilepsy who harbored cortically located supratentorial cerebral cavernous malformations underwent surgical treatment and were retrospectively analyzed.<\/jats:p><\/jats:sec>\n\nResults<\/jats:title>\nMore extensive resections were used in 82% of all patients with epilepsy symptoms for longer than 2 years. Eighty-two percent of patients with symptom duration shorter than 2 years underwent circumscribed lesionectomy including the surrounding hemosiderotic rim. The overall rate of mild permanent, unanticipated postoperative deficits was 4.5%; the rate of anticipated neurological deficits was 9%. The mean follow-up was longer than 117 months in all groups. Seizure outcome was excellent in the group with symptom duration shorter than 2 years (100% ILAE Class 1). Seizure outcome was significantly worse in the group with longer symptom duration (p = 0.02). Seven patients were seizure free after surgery. Seizure outcome was stable over the years.<\/jats:p><\/jats:sec>\n\nConclusions<\/jats:title>\nSince seizure outcome is worse with longer seizure duration, early surgery and, if needed, interdisciplinary intervention, is recommended. Even in cases of multiple cerebral cavernous malformations and epilepsy, surgery should be considered.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2014.2.peds13361","type":"journal-article","created":{"date-parts":[[2014,4,4]],"date-time":"2014-04-04T14:06:05Z","timestamp":1396620365000},"page":"699-705","source":"Crossref","is-referenced-by-count":30,"title":["Surgical management and long-term outcome of pediatric patients with different subtypes of epilepsy associated with cerebral cavernous malformations"],"prefix":"10.3171","volume":"13","author":[{"given":"Christian","family":"von der Brelie","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery and"},{"name":"Department of Neurosurgery, Unfallkrankenhaus Berlin; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Kuczaty","sequence":"additional","affiliation":[{"name":"Epileptology, University of Bonn Medical Center, Bonn;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marec","family":"von Lehe","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"},{"name":"Department of Neurosurgery, University of Bochum, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-peds13361","series-title":"Pediatr Neurosurg","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1159\/000209283","article-title":"Cavernous malformations of the central nervous system in the pediatric age group","volume":"45","author":"Acciarri","year":"2009"},{"key":"b2-peds13361","series-title":"J Neurol Neurosurg Psychiatry","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1136\/jnnp-2011-301763","article-title":"Trends in presurgical evaluation and surgical treatment of epilepsy at one centre from 1988\u20132009","volume":"84","author":"Bien","year":"2013"},{"key":"b3-peds13361","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1007\/BF00271890","article-title":"Management of cerebral cavernous angiomas in children presenting with seizures","volume":"5","author":"Buckingham","year":"1989"},{"key":"b4-peds13361","series-title":"Semin Ultrasound CT MR","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1053\/j.sult.2007.11.004","article-title":"Predictors, procedures, and perspective for temporal lobe epilepsy surgery","volume":"29","author":"Clusmann","year":"2008"},{"key":"b5-peds13361","series-title":"Zentralbl Neurochir","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1055\/s-2006-942144","article-title":"Present practice and perspective of evaluation and surgery for temporal lobe epilepsy","volume":"67","author":"Clusmann","year":"2006"},{"key":"b6-peds13361","series-title":"Rev Neurol (Paris)","first-page":"330","article-title":"[Contribution of magnetic resonance imaging in 100 cases of refractory partial epilepsy with normal CT scans.]","volume":"146","author":"Convers","year":"1990"},{"key":"b7-peds13361","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"702","DOI":"10.3171\/jns.1991.75.5.0702","article-title":"An analysis of the natural history of cavernous angiomas","volume":"75","author":"Del Curling","year":"1991"},{"key":"b8-peds13361","series-title":"J Neurosurg Sci","first-page":"343","article-title":"Surgical management of paediatric cerebral cavernomas","volume":"41","author":"Di Rocco","year":"1997"},{"issue":"Suppl 6","key":"b9-peds13361","series-title":"Epilepsia","first-page":"S29","article-title":"Problems in the assessment of cognitive effects of antiepileptic drugs","volume":"33","author":"Dodrill","year":"1992"},{"key":"b10-peds13361","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/BF00271020","article-title":"Cerebral cavernous angioma in children","volume":"5","author":"Fortuna","year":"1989"},{"key":"b11-peds13361","series-title":"Epilepsy Res","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/0920-1211(90)90033-R","article-title":"Cognitive effects of valproate","volume":"5","author":"Gallassi","year":"1990"},{"key":"b12-peds13361","series-title":"Surg Neurol","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/0090-3019(94)90262-3","article-title":"Surgical management of cavernous angiomas in children","volume":"42","author":"Giulioni","year":"1994"},{"key":"b13-peds13361","series-title":"J Neurosurg Pediatr","doi-asserted-by":"publisher","first-page":"522","DOI":"10.3171\/2011.8.PEDS09164","article-title":"Effective surgical treatment of cerebral cavernous malformations: a multicenter study of 79 pediatric patients. Clinical article","volume":"8","author":"Hugelshofer","year":"2011"},{"key":"b14-peds13361","series-title":"Neurology","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1212\/WNL.0b013e3182190f37","article-title":"Seizure risk from cavernous or arteriovenous malformations: prospective population-based study","volume":"76","author":"Josephson","year":"2011"},{"issue":"Suppl 6","key":"b15-peds13361","series-title":"Epilepsia","doi-asserted-by":"publisher","first-page":"S30","DOI":"10.1111\/j.1528-1157.1994.tb05987.x","article-title":"Vascular malformations and epilepsy: clinical considerations and basic mechanisms","volume":"35","author":"Kraemer","year":"1994"},{"key":"b16-peds13361","series-title":"Ann Neurol","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1002\/ana.410220310","article-title":"Magnetic resonance imaging in temporal lobe epilepsy: pathological correlations","volume":"22","author":"Kuzniecky","year":"1987"},{"key":"b17-peds13361","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/s00381-007-0465-8","article-title":"Management of intracranial cavernous malformation in pediatric patients","volume":"24","author":"Lee","year":"2008"},{"key":"b18-peds13361","series-title":"Neurochirurgie","first-page":"223","article-title":"[Central nervous system cavernomas in children.]","volume":"53","author":"Lena","year":"2007"},{"key":"b19-peds13361","series-title":"Epilepsy Behav","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1016\/j.yebeh.2004.08.019","article-title":"Determinants of quality of life in epilepsy","volume":"5","author":"Loring","year":"2004"},{"key":"b20-peds13361","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1227\/00006123-199510000-00001","article-title":"Intracranial cavernous malformations: lesion behavior and management strategies","volume":"37","author":"Maraire","year":"1995"},{"key":"b21-peds13361","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/BF00776709","article-title":"Cerebral cavernous malformations (cavernomas) in the pediatric age-group","volume":"7","author":"Mazza","year":"1991"},{"key":"b22-peds13361","series-title":"Neurosurg Rev","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/PL00014581","article-title":"Central nervous system cavernomas in the pediatric age group","volume":"24","author":"Mottolese","year":"2001"},{"key":"b23-peds13361","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"709","DOI":"10.3171\/jns.1991.75.5.0709","article-title":"Natural history of the cavernous angioma","volume":"75","author":"Robinson","year":"1991"},{"key":"b24-peds13361","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"38","DOI":"10.3171\/jns.1992.76.1.0038","article-title":"Cavernous angiomas of the central nervous system in children","volume":"76","author":"Scott","year":"1992"},{"key":"b25-peds13361","series-title":"Neuroimaging Clin N Am","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.nic.2012.02.008","article-title":"High-field magnetic resonance imaging for epilepsy","volume":"22","author":"Urbach","year":"2012"},{"key":"b26-peds13361","series-title":"Epilepsia","first-page":"282","article-title":"ILAE Commission Report. Proposal for a new classification of outcome with respect to epileptic seizures following epilepsy surgery","volume":"42","author":"Wieser","year":"2001"},{"key":"b27-peds13361","series-title":"Pediatr Neurosurg","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1159\/000209284","article-title":"Pediatric cavernous malformation in the central nervous system: report of 66 cases","volume":"45","author":"Xia","year":"2009"},{"key":"b28-peds13361","series-title":"Arch Neurol","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1001\/archneur.1991.00530230030016","article-title":"Secondary epileptogenesis in cerebral arteriovenous malformations","volume":"48","author":"Yeh","year":"1991"}],"container-title":["Journal of Neurosurgery: Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/13\/6\/article-p699.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/13\/6\/article-p699.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/13\/6\/article-p699.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T14:17:40Z","timestamp":1681568260000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/13\/6\/article-p699.xml"}},"subtitle":["Clinical article"],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":28,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.3171\/2014.2.peds13361","relation":{},"ISSN":["1933-0707","1933-0715"],"issn-type":[{"value":"1933-0707","type":"print"},{"value":"1933-0715","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6]]}}}