{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T22:35:04Z","timestamp":1792276504729,"version":"4.4.0"},"reference-count":12,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PED"],"published-print":{"date-parts":[[2014,7]]},"abstract":"\nObject<\/jats:title>\nSevere hydrocephalus and hydranencephaly are common congenital conditions in Kenya. In patients with these conditions, ventriculoperitoneal (VP) shunts are associated with appreciable complications and endoscopic third ventriculostomies (ETVs) have limited success. Endoscopic choroid plexus coagulation (CPC) to diminish CSF production is a potential treatment option. The purpose of this study was to evaluate the effect of CPC without ETV in infants with severe hydrocephalus or hydranencephaly.<\/jats:p><\/jats:sec>\n\nMethods<\/jats:title>\nMedical records of infants with severe congenital hydrocephalus or hydranencephaly who underwent CPC in Kijabe Hospital from November 2010 to April 2013 were reviewed retrospectively. Thirty-three patients with complete medical records and preoperative radiographic images were identified. After CPC, the infants were followed in the Kijabe Hospital outpatient department, in mobile clinics, or by telephone. Success of the CPC was defined as resolution of preoperative symptoms, stabilization of head size, and avoidance of VP shunt placement.<\/jats:p><\/jats:sec>\n\nResults<\/jats:title>\nPatients were followed from 30 to 608 days (median of 120 days). Three patients were lost to follow-up. Of the 30 evaluable patients, CPC was considered to be successful in 13 (43.3%), including 8 of 20 patients with severe hydrocephalus and 5 of 10 with hydranencephaly. Failure of CPC was evident from increased head circumference in 14 (82%) of 17 patients and from CSF leakage in 3. Of the 17 failures, 13 occurred within 3 months of surgery. Six patients died: 3 whose CPC procedures were failures, 2 whose CPC was successful, and 1 postoperatively. Of the 17 in whom CPC failed, 10 subsequently underwent VP shunt insertion.<\/jats:p><\/jats:sec>\n\nConclusions<\/jats:title>\nCPC stabilizes macrocephaly in approximately 40% of infants with severe congenital hydrocephalus and hydranencephaly and can be considered as an alternative to VP shunt placement.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2014.3.peds13488","type":"journal-article","created":{"date-parts":[[2014,4,25]],"date-time":"2014-04-25T14:10:50Z","timestamp":1398435050000},"page":"55-57","source":"Crossref","is-referenced-by-count":22,"title":["Choroid plexus coagulation in infants with extreme hydrocephalus or hydranencephaly"],"prefix":"10.3171","volume":"14","author":[{"given":"Sylvia","family":"Shitsama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nunthasiri","family":"Wittayanakorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humphrey","family":"Okechi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Leland","family":"Albright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-peds13488","series-title":"Childs Brain","first-page":"134","article-title":"Percutaneous choroid plexus coagulation in hydranencephaly","volume":"8","author":"Albright","year":"1981"},{"key":"b2-peds13488","series-title":"East Cent Afr J Surg","first-page":"55","article-title":"Complications of ventriculoperitoneal shunts in children in Dar es Salaam","volume":"10","author":"Kinasha","year":"2005"},{"key":"b3-peds13488","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1227\/01.NEU.0000365264.99133.CA","article-title":"Endoscopic choroid plexus cauterization versus ventriculoperitoneal shunt for hydranencephaly and near hydranencephaly: a prospective study","volume":"66","author":"Malheiros","year":"2010"},{"key":"b4-peds13488","series-title":"Surg Gynecol Obstet","first-page":"505","article-title":"Failure of choroid plexectomy as treatment for hydrocephalus","volume":"139","author":"Milhorat","year":"1974"},{"key":"b5-peds13488","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1007\/s00381-004-0936-0","article-title":"Endoscopic coagulation of choroid plexus as treatment for hydrocephalus: indication and surgical technique","volume":"20","author":"Morota","year":"2004"},{"key":"b6-peds13488","series-title":"East Afr Med J","first-page":"386","article-title":"Ventriculoperitoneal shunt surgery and shunt infections in children with non-tumour hydrocephalus at the Kenyatta National Hospital, Nairobi","volume":"77","author":"Mwang'ombe","year":"2000"},{"key":"b7-peds13488","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1227\/00006123-199504000-00009","article-title":"The role of endoscopic choroid plexus coagulation in the management of hydrocephalus","volume":"36","author":"Pople","year":"1995"},{"key":"b8-peds13488","series-title":"N Engl J Med","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1056\/NEJM193406282102602","article-title":"Treatment of hydrocephalus by endoscopic coagulation of the choroid plexus. Description of a new instrument and preliminary report of results","volume":"210","author":"Putnam","year":"1934"},{"key":"b9-peds13488","series-title":"Pediatr Neurosurg","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1159\/000339850","article-title":"Endoscopic choroid plexus coagulation in infants with hydranencephaly or hydrocephalus with a minimal cortical mantle","volume":"48","author":"Sandberg","year":"2012"},{"key":"b10-peds13488","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3171\/jns.1970.33.1.0001","article-title":"The treatment of nonobstructive (communicating) hydrocephalus by endoscopic cauterization of the choroid plexuses","volume":"33","author":"Scarff","year":"1970"},{"key":"b11-peds13488","series-title":"World Neurosurg","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.wneu.2010.02.009","article-title":"Pediatric hydrocephalus in East Africa: prevalence, causes, treatments, and strategies for the future","volume":"73","author":"Warf","year":"2010"},{"key":"b12-peds13488","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s00381-012-1960-0","article-title":"Choroid plexus coagulation for hydrocephalus not due to CSF overproduction: a review","volume":"29","author":"Zhu","year":"2013"}],"container-title":["Journal of Neurosurgery: Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/14\/1\/article-p55.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/14\/1\/article-p55.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/14\/1\/article-p55.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T15:59:48Z","timestamp":1681574388000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/14\/1\/article-p55.xml"}},"subtitle":["Clinical article"],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":12,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3171\/2014.3.peds13488","relation":{},"ISSN":["1933-0707","1933-0715"],"issn-type":[{"value":"1933-0707","type":"print"},{"value":"1933-0715","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7]]}}}