{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:48:44Z","timestamp":1790776124790,"version":"4.1.0"},"reference-count":12,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["SPI"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:sec>\n<jats:title>Object<\/jats:title>\n<jats:p>Neuroblastic tumors can be classified as neuroblastoma, ganglioneuroblastoma (GNB), or ganglioneuroma. Ganglioneuroblastomas consist of small, round, immature neuroblast cells and matured ganglion cells. They are most commonly found in the mediastinum and retroperitoneum; intraspinal GNBs are extremely rare. There are only 5 cases of intraspinal GNB reported in the English literature. The authors report a case of GNB of the filum terminale. The duration of follow-up after the initial treatment is longer than in any other published reports.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>A 36-year-old woman underwent resection of an intradural extramedullary tumor at L1\u20132 in 1993. Pathological diagnosis was GNB. After surgery, her symptoms resolved and she recovered to a normal condition. In 2009, when she was 53 years old, she presented to the hospital with paralysis of both legs. Magnetic resonance imaging suggested recurrence of spinal tumor. She underwent subtotal resection of the tumors, followed by 4 weeks of radiation therapy.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Neurological symptoms improved, and, after radiation therapy, the patient was able to walk with a crutch. Histological investigation of the excised tumor indicated that it was a nodular type GNB, which was consistent with the diagnosis from the time of the initial surgery in 1993. Follow-up MRI studies showed no growth of residual tumors in the 3 years following the surgery.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The authors present a rare case of spinal GNB. The duration of follow-up after the initial surgery in 1993 represents the longest description of clinical course after treatment for spinal GNB.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2014.4.spine121002","type":"journal-article","created":{"date-parts":[[2014,5,30]],"date-time":"2014-05-30T14:00:58Z","timestamp":1401458458000},"page":"270-274","source":"Crossref","is-referenced-by-count":8,"title":["Ganglioneuroblastoma of filum terminale"],"prefix":"10.3171","volume":"21","author":[{"given":"Yoshihiko","family":"Okudera","sequence":"first","affiliation":[{"name":"Departments of Orthopedic Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohisa","family":"Miyakoshi","sequence":"additional","affiliation":[{"name":"Departments of Orthopedic Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taku","family":"Sugawara","sequence":"additional","affiliation":[{"name":"Neurosurgery, Akita University Graduate School of Medicine, Akita, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michio","family":"Hongo","sequence":"additional","affiliation":[{"name":"Departments of Orthopedic Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Kasukawa","sequence":"additional","affiliation":[{"name":"Departments of Orthopedic Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Departments of Orthopedic Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Shimada","sequence":"additional","affiliation":[{"name":"Departments of Orthopedic Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-spine121002","series-title":"Cancer","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1002\/1097-0142(19810115)47:2<373::AID-CNCR2820470227>3.0.CO;2-O","article-title":"Ganglioneuroblastoma of the posterior mediastinum: a clinicopathologic review of 80 cases","volume":"47","author":"Adam","year":"1981"},{"key":"b2-spine121002","series-title":"Eur J Cancer","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1016\/j.ejca.2011.10.037","article-title":"Characteristics and outcome of patients with ganglioneuroblastoma, nodular subtype: a report from the INRG project","volume":"48","author":"Angelini","year":"2012"},{"key":"b3-spine121002","series-title":"Clin Neuropathol","first-page":"1","article-title":"Primitive neuroectodermal tumors of the cauda equina in adults with no detectable primary intracranial neoplasm\u2014three case studies","volume":"4","author":"Kepes","year":"1985"},{"key":"b4-spine121002","series-title":"J Neurosurg Spine","doi-asserted-by":"publisher","first-page":"457","DOI":"10.3171\/2011.5.SPINE10563","article-title":"Primary holocord ganglioneuroblastoma. 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