{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T22:56:15Z","timestamp":1756076175991},"reference-count":32,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2014,9]]},"abstract":"\nObject<\/jats:title>\nApproximately 25% of patients exhibit cognitive dysfunction 24 hours after carotid endarterectomy (CEA). One of the purported mechanisms of early cognitive dysfunction (eCD) is hypoperfusion due to inadequate collateral circulation during cross-clamping of the carotid artery. The authors assessed whether poor collateral circulation within the circle of Willis, as determined by preoperative CT angiography (CTA) or MR angiography (MRA), could predict eCD.<\/jats:p><\/jats:sec>\n\nMethods<\/jats:title>\nPatients who underwent CEA after preoperative MRA or CTA imaging and full neuropsychometric evaluation were included in this study (n = 42); 4 patients were excluded due to intraoperative electroencephalographic changes and subsequent shunt placement. Thirty-eight patients were included in the statistical analyses. Patients were stratified according to posterior communicating artery (PCoA) status (radiographic visualization of at least 1 PCoA vs of no PCoAs). Variables with p < 0.20 in univariate analyses were included in a stepwise multivariate logistic regression model to identify predictors of eCD after CEA.<\/jats:p><\/jats:sec>\n\nResults<\/jats:title>\nOverall, 23.7% of patients exhibited eCD. In the final multivariate logistic regression model, radiographic absence of both PCoAs was the only independent predictor of eCD (OR 9.64, 95% CI 1.43\u201364.92, p = 0.02).<\/jats:p><\/jats:sec>\n\nConclusions<\/jats:title>\nThe absence of both PCoAs on preoperative radiographic imaging is predictive of eCD after CEA. This finding supports the evidence for an underlying ischemic etiology of eCD. Larger studies are justified to verify the findings of this study. Clinical trial registration no.: NCT00597883 (http:\/\/www.clinicaltrials.gov<\/jats:ext-link>).<\/jats:p><\/jats:sec>","DOI":"10.3171\/2014.5.jns131736","type":"journal-article","created":{"date-parts":[[2014,7,4]],"date-time":"2014-07-04T13:59:10Z","timestamp":1404482350000},"page":"593-598","source":"Crossref","is-referenced-by-count":12,"title":["Radiographic absence of the posterior communicating arteries and the prediction of cognitive dysfunction after carotid endarterectomy"],"prefix":"10.3171","volume":"121","author":[{"given":"Eric S.","family":"Sussman","sequence":"first","affiliation":[{"name":"Departments of Neurological Surgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher P.","family":"Kellner","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna L.","family":"Mergeche","sequence":"additional","affiliation":[{"name":"Anesthesiology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel S.","family":"Bruce","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael M.","family":"McDowell","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric J.","family":"Heyer","sequence":"additional","affiliation":[{"name":"Anesthesiology, and"},{"name":"Neurology, Columbia University, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. 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