{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:52:42Z","timestamp":1790628762591,"version":"4.1.0"},"reference-count":32,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2014,9]]},"abstract":"\nObject<\/jats:title>\nThe prevalence of patients with asymptomatic unruptured intracranial aneurysms (UIAs) increases with the advancing age of the general population. The goal of the present study was to identify risk factors for the growth of UIAs detected with serial MR angiography (MRA) in patients 70 years of age or older.<\/jats:p><\/jats:sec>\n\nMethods<\/jats:title>\nThis prospective study enrolled 79 patients (age range 70\u201384 years) with 98 UIAs. Patients were followed up every 4 months, including an assessment of the aneurysm diameter and morphological changes on MRA, neurological status, and other medical conditions. Aneurysm growth was categorized into two different patterns on the basis of the MRA findings: 1) maximum increase in aneurysm diameter of 2 mm or more; and 2) obvious morphological change, such as the appearance of a bleb.<\/jats:p><\/jats:sec>\n\nResults<\/jats:title>\nThe mean duration of follow-up was 38.5 months (250.2 patient-years). Aneurysm rupture did not occur, but aneurysm growth was observed in 8 aneurysms (8 patients) during the study period. Univariate analysis showed that female sex, patient age \u2265 75 years, and an aneurysm location in the internal carotid artery (ICA) or middle cerebral artery (MCA) were associated with aneurysm growth (p = 0.04, p = 0.04, and p < 0.001, respectively). Multivariate analysis demonstrated that female sex was the only independent predictor of aneurysm growth (p = 0.0313, OR 2.3, 95% CI 1.3\u201330.2).<\/jats:p><\/jats:sec>\n\nConclusions<\/jats:title>\nFemale sex is an independent risk factor for the growth of UIAs in elderly patients. In addition, an age \u2265 75 years and aneurysm location in the ICA or MCA are characteristics that may warrant additional attention during follow-up imaging.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2014.5.jns132048","type":"journal-article","created":{"date-parts":[[2014,6,27]],"date-time":"2014-06-27T13:57:49Z","timestamp":1403877469000},"page":"599-604","source":"Crossref","is-referenced-by-count":44,"title":["Female sex as a risk factor for the growth of asymptomatic unruptured cerebral saccular aneurysms in elderly patients"],"prefix":"10.3171","volume":"121","author":[{"given":"Yoshitaka","family":"Kubo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Koji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kashimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasunari","family":"Otawara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuniaki","family":"Ogasawara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-jns132048","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1227\/01.NEU.0000336764.92606.1D","article-title":"Pitavastatin suppresses formation and progression of cerebral aneurysms through inhibition of the nuclear factor \u03f0B pathway","volume":"64","author":"Aoki","year":"2009"},{"key":"b2-jns132048","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1161\/STROKEAHA.108.519165","article-title":"Intracranial aneurysm enlargement on serial magnetic resonance angiography: frequency and risk factors","volume":"40","author":"Burns","year":"2009"},{"key":"b3-jns132048","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"190","DOI":"10.3171\/2013.3.JNS121469","article-title":"Enlargement of small, asymptomatic, unruptured intracranial aneurysms in patients with no history of subarachnoid hemorrhage: the different factors related to the growth of single and multiple aneurysms. 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