{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T12:52:44Z","timestamp":1780491164169,"version":"3.54.1"},"reference-count":36,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FOC"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:sec>\n                    <jats:title>Object<\/jats:title>\n                    <jats:p>Bacterial spinal infections are infrequent but may lead to significant morbidity and death. Apart from neurological complications, infections may also lead to bone destruction resulting in deformity of the spine. However, the incidence of spinal deformities and risk factors is not well characterized in the literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study was conducted using electronic medical records at a single institution. All patients were over 18 years of age and had a clinically and radiologically documented spinal infection that was treated surgically during the period 2006\u20132013. Infections were classified according to anatomical location including disc, bone, and\/or epidural space. Deformities included kyphosis and\/or subluxation. The authors analyzed risk factors for developing at least 1 deformity between the time of infection and operation using the Fisher exact test and chi-square test. Change in visual analog scale (VAS) scores preoperatively versus postoperatively was also analyzed using the paired t-test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study included 48 patients. The most common types of spinal infections were osteomyelitis and discitis (31%); osteomyelitis, discitis, and spinal epidural abscess (SEA; 27%); SEA only (15%); and osteomyelitis only (13%). Overall, 21 (44%) of 48 patients developed a spinal deformity. Anatomical location of infection (bone and\/or disc and\/or epidural space) was significantly associated with development of deformity (p &lt; 0.001). In particular, patients with SEA had lower odds of deformity compared with patients without SEA (odds ratio 0.2, 95% confidence interval 0.05\u20130.9; p &lt; 0.001). No other factor was significantly associated with deformity. Pain measured by VAS score tended to improve by a mean of 1.7 \u00b1 2.7 points (p &lt; 0.001) when comparing preoperative to postoperative scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this cohort of patients, 44% developed at least 1 deformity, predominantly kyphosis. The only variable significantly associated with deformity was infection location. Patients with SEA alone demonstrated lower odds of developing a deformity compared with patients without SEA. Other analyzed variables, including age, body mass index, time from initial diagnosis to surgery, and comorbidities, were not found to be associated with development of deformity. Surgical intervention resulted in pain improvement.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2014.6.focus14143","type":"journal-article","created":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T03:47:18Z","timestamp":1406864838000},"page":"E2","source":"Crossref","is-referenced-by-count":20,"title":["Risk factors for the development of deformity in patients with spinal infection"],"prefix":"10.3171","volume":"37","author":[{"given":"Dushyanth","family":"Srinivasan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel W.","family":"Terman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Himedan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Dugo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"La Marca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"47","key":"b1-focus14143","series-title":"Surg Neurol","first-page":"551","article-title":"Surgical management of nontuberculous thoracic and lumbar vertebral osteomyelitis: report of 33 cases","author":"Arnold","year":"1997"},{"key":"b2-focus14143","series-title":"J Bone Joint Surg Am","doi-asserted-by":"publisher","first-page":"874","DOI":"10.2106\/00004623-199706000-00011","article-title":"Pyogenic vertebral osteomyelitis","volume":"79","author":"Carragee","year":"1997"},{"key":"b3-focus14143","series-title":"Eur Spine J","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1007\/s00586-006-0251-4","article-title":"Surgical treatment of pyogenic vertebral osteomyelitis with spinal instrumentation","volume":"16","author":"Chen","year":"2007"},{"key":"b4-focus14143","series-title":"N Engl J Med","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.1056\/NEJMra055111","article-title":"Spinal epidural abscess","volume":"355","author":"Darouiche","year":"2006"},{"key":"b5-focus14143","series-title":"J Bone Joint Surg Am","doi-asserted-by":"publisher","first-page":"19","DOI":"10.2106\/00004623-198365010-00004","article-title":"Pyogenic and fungal vertebral osteomyelitis with paralysis","volume":"65","author":"Eismont","year":"1983"},{"issue":"6","key":"b6-focus14143","series-title":"Neurosurg Focus","first-page":"E4","article-title":"Surgical strategies for vertebral osteomyelitis and epidural abscess","volume":"17","author":"Hsieh","year":"2004"},{"key":"b7-focus14143","series-title":"J Comput Assist Tomogr","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1097\/00004728-199609000-00005","article-title":"MR of disc protrusion engendered by infectious spondylitis","volume":"20","author":"Jinkins","year":"1996"},{"key":"b8-focus14143","series-title":"Lancet","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/S0140-6736(04)16727-5","article-title":"Osteomyelitis","volume":"364","author":"Lew","year":"2004"},{"key":"b9-focus14143","series-title":"Arch Intern Med","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1001\/archinte.1988.00380020161021","article-title":"Vertebral osteomyelitis presenting as spinal compression fracture. 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