{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T22:43:07Z","timestamp":1782168187502,"version":"3.54.5"},"reference-count":42,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p>The authors report 2 cases of orthostatic headaches associated with spontaneous intracranial hypotension (SIH) secondary to CSF leaks that were successfully treated with an alternative dural repair technique in which a tubular retractor system and a hydrogel dural sealant were used. The 2 patients, a 63-year-old man and a 45-year-old woman, presented with orthostatic headache associated with SIH secondary to suspected lumbar and lower cervical CSF leaks, respectively, as indicated by bony defects or epidural fluid collection. Epidural blood patch repair failed in both cases, but both were successfully treated with the minimally invasive application of a hydrogel dural sealant as a novel adjunct to traditional dural repair techniques. Both patients tolerated the procedure well. Moreover, SIH symptoms and MRI signs were completely resolved at 1-month follow-up in both patients.<\/jats:p>\n<jats:p>The minimally invasive dural repair procedure with hydrogel dural sealant described here offers a viable alternative in patients in whom epidural blood patches have failed, with obscure recalcitrant CSF leaks at the cervical as well as lumbar spinal level. The authors demonstrate that the adjuvant use of sealant is a safe and efficient repair method regardless of dural defect location.<\/jats:p>","DOI":"10.3171\/2014.6.jns13714","type":"journal-article","created":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T14:21:59Z","timestamp":1406902919000},"page":"976-982","source":"Crossref","is-referenced-by-count":5,"title":["Novel hydrogel application in minimally invasive surgical approaches to spontaneous intracranial hypotension"],"prefix":"10.3171","volume":"121","author":[{"given":"Casey M.","family":"Chai","sequence":"first","affiliation":[{"name":"Weill Cornell Brain Tumor and Stem Cell Laboratory,"},{"name":"Weill Cornell Medical College,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matei A.","family":"Banu","sequence":"additional","affiliation":[{"name":"Weill Cornell Brain Tumor and Stem Cell Laboratory,"},{"name":"Weill Cornell Medical College,"},{"name":"Department of Neurological Surgery, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Cobb","sequence":"additional","affiliation":[{"name":"Weill Cornell Brain and Spine Center,"},{"name":"Department of Neurological Surgery, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neel","family":"Mehta","sequence":"additional","affiliation":[{"name":"Weill Cornell Brain and Spine Center,"},{"name":"Department of Neurological Surgery, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Heier","sequence":"additional","affiliation":[{"name":"Weill Cornell Medical College,"},{"name":"Department of Radiology, NewYork-Presbyterian Hospital, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Boockvar","sequence":"additional","affiliation":[{"name":"Weill Cornell Brain Tumor and Stem Cell Laboratory,"},{"name":"Weill Cornell Medical College,"},{"name":"Weill Cornell Brain and Spine Center,"},{"name":"Department of Neurological Surgery, and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-jns13714","series-title":"Anesth Analg","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1213\/00000539-197554040-00012","article-title":"Long-term followup of epidural blood patch","volume":"54","author":"Abouleish","year":"1975"},{"key":"b2-jns13714","series-title":"Neurol Sci","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s10072-006-0566-2","article-title":"A complicated case of intracranial hypotension: diagnostic and management strategies","volume":"27","author":"Akkawi","year":"2006"},{"key":"b3-jns13714","series-title":"Anesth Analg","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1213\/00000539-199701000-00059","article-title":"Intrathecal hematoma and arachnoiditis after prophylactic blood patch through a catheter","volume":"84","author":"Aldrete","year":"1997"},{"key":"b4-jns13714","series-title":"Neurology","doi-asserted-by":"publisher","first-page":"1950","DOI":"10.1212\/01.WNL.0000144339.34733.E9","article-title":"Early epidural blood patch in spontaneous intracranial hypotension","volume":"63","author":"Berroir","year":"2004"},{"issue":"4 Suppl","key":"b5-jns13714","series-title":"J Neurosurg","first-page":"302","article-title":"Hydrogel-induced cervicomedullary compression after posterior fossa decompression for Chiari malformation. 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