{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T14:05:56Z","timestamp":1744812356927},"reference-count":9,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PED"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:p>Medulla oblongata teratomas are rare. The authors report 2 new cases of teratomas that occurred exclusively in the medulla oblongata. The first case was in a 9-year-old boy who presented with a 6-month history of neck pain and repeated paroxysmal vomiting. Based on preoperative radiographic findings, the initial diagnosis was of an intraaxial medulla oblongata hemangioblastoma. Intraoperatively, the cystic component of the tumor was gray, gelatinous, and soft in consistency. The solid component was light pink, rubbery, and nodular in appearance, with an identifiable boundary. The lesion was completely removed. Histopathological investigation revealed a mature teratoma. Postoperatively, the patient was supported with ventilator assistance and received a tracheotomy, but died of intracranial infection. The second case was in a 10-year-old boy with intermittent headache for 1 month. Radiographs revealed an exophytic cystic and solid lesion with dorsal involvement of the medulla oblongata. The lesion was predominantly solid, pinkish gray, tenacious, and moderately vascularized, with clearly delineated surgical dissection planes. The histopathological examination confirmed a diagnosis of immature teratoma. Total resection was achieved, followed by postoperative chemotherapy. He was alive without recurrence of the lesion or symptoms at 59 months after surgery.<\/jats:p>\n<jats:p>Resection of medulla oblongata teratoma is challenging, with inherent surgical risks that are contingent on the tumor growth pattern. Teratomas should be considered in the differential diagnosis of brainstem lesions. Chemotherapy has been suggested for immature teratomas. Long-term follow-up and larger studies of teratomas in unusual locations are required to improve practitioners' understanding of this disease's treatment and outcomes.<\/jats:p>","DOI":"10.3171\/2014.6.peds1423","type":"journal-article","created":{"date-parts":[[2014,7,4]],"date-time":"2014-07-04T13:59:32Z","timestamp":1404482372000},"page":"296-300","source":"Crossref","is-referenced-by-count":5,"title":["Primary medulla oblongata teratomas"],"prefix":"10.3171","volume":"14","author":[{"given":"Da","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Yu","family":"Hao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Ting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-peds1423","series-title":"Pediatr Neurosurg","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1159\/000103319","article-title":"Massive congenital intracranial immature teratoma of the lateral ventricle with retro-orbital extension: a case report and review of the literature","volume":"43","author":"Arslan","year":"2007"},{"key":"b2-peds1423","series-title":"J Neurosurg Pediatr","doi-asserted-by":"publisher","first-page":"38","DOI":"10.3171\/2013.9.PEDS1347","article-title":"Successful treatment of hemorrhagic congenital intracranial immature teratoma with neoadjuvant chemotherapy and surgery. Case report","volume":"13","author":"Fukuoka","year":"2014"},{"key":"b3-peds1423","series-title":"J Clin Neurosci","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.jocn.2010.03.061","article-title":"Fourth-ventricular immature teratoma","volume":"18","author":"Furtado","year":"2011"},{"key":"b4-peds1423","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"2035","DOI":"10.1007\/s00381-013-2091-y","article-title":"Intracranial teratomas in children: a clinicopathological study","volume":"29","author":"Goyal","year":"2013"},{"key":"b5-peds1423","series-title":"World J Surg Oncol","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1186\/1477-7819-11-274","article-title":"Primary medulla oblongata germinomas: two case reports and review of the literature","volume":"11","author":"Hao","year":"2013"},{"key":"b6-peds1423","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"106","DOI":"10.3171\/jns.2003.99.1.0106","article-title":"Successful treatment of intracranial nongerminomatous malignant germ cell tumors by administering neoadjuvant chemotherapy and radiotherapy before excision of residual tumors","volume":"99","author":"Kochi","year":"2003"},{"key":"b7-peds1423","series-title":"J Neurosurg Pediatr","doi-asserted-by":"publisher","first-page":"137","DOI":"10.3171\/2009.3.PEDS08290","article-title":"Mixed germ cell tumor of the midbrain. Case report","volume":"4","author":"Koh","year":"2009"},{"key":"b8-peds1423","series-title":"Clin Neurol Neurosurg","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/S0303-8467(98)00050-X","article-title":"Primary intracranial germinoma involving the midbrain","volume":"100","author":"Matsumoto","year":"1998"},{"key":"b9-peds1423","series-title":"Acta Neurochir (Wien)","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1007\/PL00010098","article-title":"Malignant teratoma of the medulla oblongata in an adult male","volume":"143","author":"Tsuzuki","year":"2001"}],"container-title":["Journal of Neurosurgery: Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/14\/3\/article-p296.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/14\/3\/article-p296.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/14\/3\/article-p296.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T16:01:14Z","timestamp":1681574474000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/14\/3\/article-p296.xml"}},"subtitle":["Report of 2 cases"],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":9,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.3171\/2014.6.peds1423","relation":{},"ISSN":["1933-0707","1933-0715"],"issn-type":[{"value":"1933-0707","type":"print"},{"value":"1933-0715","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9]]}}}