{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T18:04:03Z","timestamp":1769969043856,"version":"3.49.0"},"reference-count":14,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PED"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:p>The authors report the case of an 11-year-old immunocompetent boy with primary CNS CD30-positive anaplastic large-cell lymphoma (ALCL) that was also positive for anaplastic lymphoma kinase-1. His initial clinical manifestation was acute meningitis of unknown etiology. Findings on CT scanning were normal. Although he received empirical treatment against infection, his systemic and neurological status deteriorated. Subsequent MRI revealed newly emerged enhanced lesions and concomitant edema in the left parietal lobe. Diagnosis was confirmed following a brain biopsy and immunohistochemical staining. Three courses of systemic high-dose methotrexate (HD-MTX) treatment with 2-week intervals was started, followed by whole-brain radiation. His clinical course improved, and he has remained disease-free for more than 8 years without any additional treatment. Because ALCL originating in the brain is extremely rare and difficult to diagnose, no standard treatment has been established. This report suggests that systemic HD-MTX monotherapy can be an effective and worthwhile tailored therapeutic option for pediatric primary CNS ALCL.<\/jats:p>","DOI":"10.3171\/2014.6.peds1492","type":"journal-article","created":{"date-parts":[[2014,7,11]],"date-time":"2014-07-11T14:12:26Z","timestamp":1405087946000},"page":"311-315","source":"Crossref","is-referenced-by-count":10,"title":["High-dose methotrexate monotherapy followed by radiation for CD30-positive, anaplastic lymphoma kinase-1\u2013positive anaplastic large-cell lymphoma in the brain of a child"],"prefix":"10.3171","volume":"14","author":[{"given":"Kazuhide","family":"Furuya","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigehiko","family":"Takanashi","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihisa","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Pathology, Teikyo University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadayoshi","family":"Nakagomi","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-peds1492","series-title":"Hum Pathol","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1016\/S0046-8177(99)90253-8","article-title":"Primary anaplastic large cell lymphoma of the central nervous system","volume":"30","author":"Abdulkader","year":"1999"},{"key":"b2-peds1492","series-title":"Pediatr Neurosurg","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1159\/000028731","article-title":"Primary Ki-1-positive T-cell lymphoma of the brain in a child","volume":"29","author":"Buxton","year":"1998"},{"key":"b3-peds1492","series-title":"Acta Haematol","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1159\/000203862","article-title":"Leptomeningeal seeding with acute hydrocephalus\u2014unusual central nervous system presentation during chemotherapy in Ki-1-positive anaplastic large-cell lymphoma","volume":"95","author":"Chen","year":"1996"},{"key":"b4-peds1492","series-title":"Clin Neuropathol","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1182\/blood.V96.12.3681","article-title":"Rare primary CNS anaplastic large cell lymphoma in an immunocompetent adult: a clinical-pathologic case report and review case of the literature","volume":"25","author":"Cooper","year":"2006"},{"key":"b5-peds1492","series-title":"J Clin Oncol","doi-asserted-by":"publisher","first-page":"4643","DOI":"10.1200\/JCO.2002.11.013","article-title":"Combination chemotherapy and radiotherapy for primary central nervous system lymphoma: Radiation Therapy Oncology Group Study 93-10","volume":"20","author":"DeAngelis","year":"2002"},{"key":"b6-peds1492","series-title":"Neurology","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1212\/WNL.58.10.1513","article-title":"A multicenter study of treatment of primary CNS lymphoma","volume":"58","author":"Ferreri","year":"2002"},{"key":"b7-peds1492","series-title":"Am J Surg Pathol","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1097\/00000478-200304000-00008","article-title":"Primary anaplastic large cell lymphoma of the central nervous system: prognostic effect of ALK-1 expression","volume":"27","author":"George","year":"2003"},{"key":"b8-peds1492","series-title":"Surg Neurol","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/0090-3019(96)00033-X","article-title":"Primary Ki-1-positive T-cell lymphoma of the brain\u2014an aggressive subtype of lymphoma: case report and review of the literature","volume":"46","author":"Goldbrunner","year":"1996"},{"key":"b9-peds1492","series-title":"Am J Clin Pathol","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1093\/ajcp\/103.4.496","article-title":"Primary Ki-1 (anaplastic large cell) lymphoma of the brain and spinal cord","volume":"103","author":"Havlioglu","year":"1995"},{"key":"b10-peds1492","series-title":"Pediatr Neurosurg","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1159\/000108799","article-title":"Primary cerebral ALK-1-positive anaplastic large cell lymphoma in a child. Case report and literature review","volume":"43","author":"Karikari","year":"2007"},{"key":"b11-peds1492","series-title":"J Clin Neurosci","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1054\/jocn.2000.0854","article-title":"Primary Ki-1 lymphoma in the central nervous system","volume":"8","author":"Kawamura","year":"2001"},{"key":"b12-peds1492","series-title":"J Pediatr Hematol Oncol","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1097\/MPH.0b013e31818a959a","article-title":"Primary leptomeningeal ALK+ lymphoma in a 13-year-old child","volume":"30","author":"Merlin","year":"2008"},{"key":"b13-peds1492","series-title":"Ann Oncol","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1093\/annonc\/mdf300","article-title":"Primary brain CD30+ ALK1+ anaplastic large cell lymphoma (\u2018ALKoma'): the first case with a combination of \u2018not common' variants","volume":"13","author":"Ponzoni","year":"2002"},{"key":"b14-peds1492","series-title":"Blood","first-page":"3681","article-title":"CD30(+) anaplastic large cell lymphoma: a review of its histopathologic, genetic, and clinical features","volume":"96","author":"Stein","year":"2000"}],"container-title":["Journal of Neurosurgery: Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/14\/3\/article-p311.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/14\/3\/article-p311.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/14\/3\/article-p311.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T16:01:14Z","timestamp":1681574474000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/14\/3\/article-p311.xml"}},"subtitle":["Case report"],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":14,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.3171\/2014.6.peds1492","relation":{},"ISSN":["1933-0707","1933-0715"],"issn-type":[{"value":"1933-0707","type":"print"},{"value":"1933-0715","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9]]}}}