{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T18:44:07Z","timestamp":1782758647873,"version":"3.54.5"},"reference-count":40,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["SPI"],"published-print":{"date-parts":[[2014,11]]},"abstract":"\nObject<\/jats:title>\nThe authors assess the utility of routine biopsy at vertebroplasty for vertebral compression fracture (VCF) as a tool in the early detection of malignancy in presumed benign VCF.<\/jats:p><\/jats:sec>\n\nMethods<\/jats:title>\nA prospective observational study was conducted on a cohort of consecutive patients undergoing vertebroplasty over a 5-year period between April 2006 and March 2011 at the Royal London Hospital. Polymethylmethacrylate cement injection was used in every procedure. Intraoperative vertebral body biopsy was performed routinely at every level of VCF. Pain visual analog scale (VAS) scores, Oswestry Disability Index (ODI) scores, analgesic usage, and complications were recorded preoperatively and at 1 day, 1 week, 1 month, 6 months, and 1 year postoperatively.<\/jats:p><\/jats:sec>\n\nResults<\/jats:title>\nA total of 202 levels were augmented in 147 patients. The most common levels augmented were T-12 (17%), L-1 (18%), and L-4 (10%). Analysis of 184 routine vertebral biopsies in 135 patients revealed that in 86 patients with presumed osteoporosis and no prior cancer diagnosis, 4 (4.7%) had a malignant VCF. In 20 known cancer patients presumed to be in remission, 2 (10%) had a malignant VCF. Routine vertebral biopsy returned an overall cancer diagnosis rate of 5.5% (6 of 109) when combining the 2 groups (patients with no prior history of cancer or cancer thought to be in remission). In these 6 patients, history, examination, laboratory tests, and preprocedure imaging all failed to suggest malignancy diagnosed at routine biopsy. Significant reductions in pain VAS and ODI scores were evident at Day 1 and were sustained at up to 1 year postoperatively (p < 0.001). They were not dependent on the level of fracture (T3\u201310, T11\u2013L2, or L3\u2013S1) (p > 0.05), number of levels treated (single level, 2 levels, or > 2 levels) (p > 0.05), or etiology of VCF (p > 0.05). The complication rate was 6% (9 of 147). There were 5 deaths, none of which were directly related to surgery.<\/jats:p><\/jats:sec>\n\nConclusions<\/jats:title>\nRoutine vertebral biopsy performed at vertebroplasty may demonstrate cancer-related VCFs in unsuspected patients with no previous cancer diagnosis or active malignancy in patients previously thought to be in remission. This early diagnosis of cancer or relapsed disease will play an important role in expediting patients' subsequent cancer management. In cases of multiple-level VCF, the authors advocate biopsy at each level to maximize the diagnostic yield from the specimens and to avoid missing a malignancy at a single level.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2014.7.spine121015","type":"journal-article","created":{"date-parts":[[2014,8,15]],"date-time":"2014-08-15T16:42:52Z","timestamp":1408120972000},"page":"687-697","source":"Crossref","is-referenced-by-count":20,"title":["Utility of routine biopsy at vertebroplasty in the management of vertebral compression fractures: a tertiary center experience"],"prefix":"10.3171","volume":"21","author":[{"given":"Soumya","family":"Mukherjee","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Royal London Hospital, London ; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhaskar","family":"Thakur","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Royal London Hospital, London ; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolin","family":"Bhagawati","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Royal London Hospital, London ; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimpu","family":"Bhagawati","sequence":"additional","affiliation":[{"name":"Department of Trauma & Orthopaedic Surgery, John Radcliffe Hospital, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samira","family":"Akmal","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Royal London Hospital, London ; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasileios","family":"Arzoglou","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Royal London Hospital, London ; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Yeh","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Royal London Hospital, London ; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Habib","family":"Ellamushi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Royal London Hospital, London ; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-spine121015","series-title":"Acta Orthop Scand","doi-asserted-by":"publisher","first-page":"129","DOI":"10.3109\/17453677608989707","article-title":"Fine needle aspiration biopsy in the evaluation of tumor-like lesions of bone","volume":"47","author":"Akerman","year":"1976"},{"key":"b2-spine121015","series-title":"Spine (Phila Pa 1976)","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.1097\/00007632-199508150-00005","article-title":"Can we distinguish between benign versus malignant compression fractures of the spine by magnetic resonance imaging?","volume":"20","author":"An","year":"1995"},{"issue":"24 Suppl","key":"b3-spine121015","series-title":"Spine (Phila Pa 1976)","doi-asserted-by":"publisher","first-page":"38S","DOI":"10.1097\/00007632-199712151-00007","article-title":"Future directions. 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